Developmental Core

发展核心

• 批准号: 10431022
• 负责人: JONATHAN E. GOLUB
• 金额: $ 28.51万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-16 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10431022
• 关键词: Accountability; Address; Adherence; Applications Grants; Area; Arts; Award; Basic Science; Bioinformatics; Clinical Research; Collaborations; Communities; Development; Discipline; Discipline of Nursing; Educational workshop; Engineering; FAIR principles; Faculty; Feedback; Funding; Future; Goals; Grant; Grant Review; Health; Health Services Accessibility; Human; Immunologist; Individual; Infection Control; Infection prevention; Investments; K-Series Research Career Programs; Knowledge; Leadership; Mentors; Mentorship; Methodology; Mission; Modeling; Nursing Models; Outcomes Research; Pathogenesis; Prevention; Productivity; Public Health; Research; Research Methodology; Research Personnel; Research Priority; Research Training; Resources; Science; Scientist; Seeds; Series; Study Section; Systems Biology; Training; Training Support; Translations; Universities; Work; Writing; career; career development; clinical investigation; co-infection; community based participatory research; comorbidity; cost effectiveness; high risk; implementation science; innovation; interest; mHealth; medical schools; meetings; molecular diagnostics; multidisciplinary; next generation; novel; novel strategies; programs; recruit; skills; therapeutic vaccine; training opportunity

ABSTRACT – JHU TRAC DEVELOPMENTAL CORE (DC) The mission of the Developmental Core (DC) is to support and mentor the next generation of TB researchers and to recruit new TB investigators to increase the diversity and breadth of TB scientists at Johns Hopkins University (JHU). Early Stage Investigators (ESI) need to integrate a variety of disciplines into their work, and innovative leaders in other fields need to be brought into the TB research fold to generate transformational gains in basic and clinical research, translation, and implementation. Despite the productivity and accomplishments of the JHU faculty, nurturing and sustaining a pipeline of New Investigators (NI) who can provide leadership and innovation in the future is extremely challenging. Without dedicated resources to support NI and ESI, many trainees move onto other fields. There is a recognized need for seed funding, core resources, and intensive mentoring for new researchers, who also would benefit from broadened skill sets beyond their primary training. The DC will seek to draw from areas of underrepresented science and scientists, including opportunities for future research/training. Fields such as systems biology in TB are lacking; thus, we will seek to bring in computational modelers, bioinformaticians, and immunologists to fill this void. Novel approaches to understanding TB pathogenesis are needed, with implications for molecular diagnostics, therapeutic vaccines, and host-directed therapies. Nursing models to increase prevention, access to treatment, retention and human- centered adherence models, as well as infection control and prevention science are recognized areas needing TB outsiders. Finally, engagement of stakeholders in community-based participatory research methods is increasingly needed in TB control globally. The overall goals of the JHU TRAC DC are to support the highest priority innovative, cross-disciplinary TB research, to support and mentor ESI in team science, and to recruit and support NI to TB. Developmental Awards provided by the DC will provide both ESI and established investigators not currently involved in TB research with the opportunity to stimulate innovative ideas and to receive support for fruitful new areas of interdisciplinary, collaborative research. A special focus of the DC will be the recruitment and career development of Investigators among groups nationally underrepresented in health-related research (UHRR). In addition to the Developmental Awards, the Developmental Core will augment individual mentorship with Internal Scientific Reviews of grant proposals, including specific aims reviews; TRAC-specific Writing Accountability Groups (WAGs), a TRAC K- Club to support development of K01, K08, K23, or K99 applications, and a TRAC K2R Club for investigators transitioning from K awards to R01 grants. The Developmental Core will work with the Administrative Core to facilitate exchange of ideas and methodologies through a weekly TRAC Seminar Series, research-in-progress meetings, workshops, and the annual JHU TB Scientific Meeting and TRAC Data Fair.

摘要 – JHU TRAC 发展核心 (DC) 发展核心 (DC) 的使命是支持和指导下一代结核病研究人员 并招募新的结核病研究人员，以增加约翰·霍普金斯大学结核病科学家的多样性和广度 大学 (JHU)。早期研究者 (ESI) 需要将各种学科融入到他们的工作中，并且 需要将其他领域的创新领导者纳入结核病研究领域，以产生变革性收益 尽管生产力和成就很高，但在基础和临床研究、翻译和实施方面。 约翰霍普金斯大学 (JHU) 的教职人员，培养和维持一批新研究者 (NI)，他们可以提供领导力和 如果没有专门的资源来支持 NI 和 ESI，未来的创新将面临极大的挑战。 受训人员转向其他领域，人们普遍认为需要种子资金、核心资源和强化培训。 为新研究人员提供指导，他们也将从初级培训之外的更广泛的技能中受益。 DC 将寻求从代表性不足的科学和科学家领域汲取经验，包括为 未来的研究/培训领域缺乏，例如结核病的系统生物学； 计算建模师、生物信息学家和免疫学家填补了这一空白。 需要了解结核病的发病机制，这对分子诊断、治疗性疫苗、 和以宿主为导向的治疗模式，以增加预防、获得治疗、保留和人性化的治疗。 以中心为中心的依从模型以及感染控制和预防科学是公认需要的领域 最后，利益相关者参与基于社区的参与性研究方法是重要的。 全球结核病控制的需求日益增加。 JHU TRAC DC 的总体目标是支持最优先的创新、跨学科结核病 研究，支持和指导 ESI 的团队科学，并招募和支持 NI 获得 TB 发展奖。 由 DC 提供的信息将为 ESI 和目前未参与结核病研究的既定研究者提供 有机会激发创新想法并获得跨学科新领域的支持， DC 的一个特别重点是研究人员的招募和职业发展。 除了发展研究之外，在全国范围内健康相关研究（UHRR）中代表性不足的群体。 奖项、发展核心将通过拨款的内部科学审查来加强个人指导 提案，包括 TRAC 特定写作责任小组 (WAG)、TRAC K- 支持 K01、K08、K23 或 K99 应用程序开发的俱乐部，以及供研究人员使用的 TRAC K2R 俱乐部 从 K 奖励过渡到 R01 补助金。发展核心将与行政核心合作，以实现 通过每周举行的 TRAC 研讨会系列、正在进行的研究促进思想和方法的交流 会议、研讨会以及年度 JHU TB 科学会议和 TRAC 数据博览会。