Acquisition of a Surface Plasmon Resonance Instrument

获得表面等离子共振仪器

• 批准号: 10431408
• 负责人: Adrian Whitty
• 金额: $ 40.58万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10431408
• 关键词: 15 year old; Address; Advisory Committees; Area; Biochemistry; Biological Sciences; Biology; Biomedical Engineering; Boston; Chemicals; Chemistry; Faculty; Future; Infrastructure; Investigation; Investments; Laboratories; Life; Ligands; Minor; Modeling; Optics; Play; Postdoctoral Fellow; Process; Research; Research Personnel; Role; Scientist; Students; Supervision; Surface Plasmon Resonance; Technical Expertise; Time; Training; United States National Institutes of Health; Universities; Wages; biophysical properties; career; design; graduate student; instrument; instrumentation; member; post-doctoral training; professor; programs; small molecule; student training

Project Summary/Abstract The Boston University Department of Chemistry seeks NIH support to acquire a Cytiva Biacore S200 Surface Plasmon Resonance (SPR) instrument to address a critical need for biophysical characterization. The requested instrument will replace a >15-year-old model that recently became irreparably inoperable. It will enable investigators on the CRC to advance their research in life processes (chemistry, biology, biochemistry and biomedical engineering), will allow their investigations to move into new areas, and will enrich student and postdoctoral training. The requested instrument is critical to the research programs of 8 Major Users (Professors Allen, Beeler, Galagan, Harris, Ngo, Schaus, Vegas, and Whitty) and 5 Minor Users (Professors, Brown, Perlstein, Porco, Vajda, and Wong) spanning five academic departments. The requested instrument will restore the ability of these investigators to use SPR in their research, enhancing our biophysical characterization capability to meet the current and evolving research needs of the faculty and students, and provide new capabilities to support small molecule ligand discovery. The SPR instrument will thus play a pivotal role in BU’s expansion of its life science research. The University’s commitment is demonstrated by its investment in the infrastructure for supporting multi-user research instruments, and by its provision of salary for full time technical support staff. In 2005, BU completed construction of the 5,500 sq.-ft. Chemical Instrumentation Center (CIC), which was designed with specific space and support staff designated for bench-top optical instrumentation. The CIC’s Director, Dr. Norman Lee, will manage the usage and finances of the requested instrument, and the CIC Staff Dr. Stephen Whelan will operate and maintain the instrument and provide user training. The CIC has a demonstrated management plan for the instrument’s usage, financial supervision, and scientific oversight, including a nine-member Advisory Committee with representatives from users and non-users. The graduate students and postdoctoral fellows in the laboratories of the users will use this instrument extensively as part of their research. This training of young scientists will facilitate their research objectives, while providing them with additional technical skills for succeeding in their future professional careers.

项目概要/摘要 波士顿大学化学系寻求 NIH 支持购买 Cytiva Biacore S200 表面等离子共振 (SPR) 仪器可满足生物物理学的关键需求 所要求的仪器将取代最近使用超过 15 年的型号。 它将使得 CRC 的研究人员能够推进他们的研究。 在生命过程（化学、生物学、生物化学和生物医学工程）中，将允许他们 调查进入新领域，并将丰富学生和博士后培训。 所请求的仪器对于 8 位主要用户（Allen 教授、 Beeler、Galagan、Harris、Ngo、Schaus、Vegas 和 Whitty）和 5 位小用户（教授、Brown、 Perlstein、Porco、Vajda 和 Wong）横跨五个学术部门。 仪器将恢复这些研究人员在研究中使用 SPR 的能力，增强 我们的生物物理表征能力可以满足当前和不断变化的研究需求 教师和学生，并提供支持小分子配体发现的新功能。 因此，SPR 仪器将在 BU 扩大生命科学研究的过程中发挥关键作用。 大学对基础设施的投资证明了其承诺 多用户研究仪器，并为全职技术支持人员提供工资。 2005年，BU完成了5,500平方英尺的化学仪器中心（CIC）的建设， 其设计有专门用于台式光学的特定空间和支持人员 CIC 主任 Norman Lee 博士将管理该仪器的使用和财务。 请求的仪器，CIC 工作人员 Stephen Whelan 博士将操作和维护该仪器 CIC 拥有经过验证的管理计划。 仪器的使用、财务监督和科学监督，包括九名成员 由用户和非用户代表组成的咨询委员会。 用户实验室的博士后研究员将广泛使用该仪器作为 对年轻科学家的培训将促进他们的研究目标，同时 为他们提供额外的技术技能，帮助他们在未来的职业生涯中取得成功。