Supplement to Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling

在交叉偶联中利用烷基胺和烷基醇的补充

• 批准号: 10436560
• 负责人: Mary P Watson
• 金额: $ 4.82万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10436560
• 关键词: Alcohols; Alkenes; Amines; Biology; Chemistry; Chlorides; Coupling; Cyclization; Development; Educational process of instructing; Educational workshop; Future; Goals; Mentors; Periodicity; Reaction; Research; Salts; Series; Training; career networking; experience; graduate student; insight; method development; programs; success

This supplement to R35 GM131816 is focused on the development of a series of new deaminative cross-couplings and the training of graduate student Bria Garcia, in line with the goals of PA-21- 071. The scientific goals of this supplement are to develop (1) reductive cross-electrophile couplings of alkylpyridinium salts and (hetero)aryl chlorides, and (2) cascade cyclizations of alkylpyridinium salts tethered to alkenes to deliver a range of cyclic products. Both these reactions transform readily available starting materials into valuable motifs found in bioactive molecules. This research will hone Ms. Garcia’s expertise in catalytic method development. It will also greatly enhance her research capabilities by giving her experiences in high-throughput experimentation (HTE), collaborative interactions and insight with medicinal chemists at Pfizer, Inc., and proficiency in developing stereoselective transformations. This supplement proposal also includes a mentoring plan, including participation in UD’s Chemistry-Biology Interface program, multiple courses and workshops, teaching and mentoring experience, and professional networking opportunities, to maximize Ms. Garcia’s training and future success.

此补充对 R35 GM131816 的重点是开发一系列新的脱氨基剂 交叉耦合和研究生 Bria Garcia 的培训，符合 PA-21 的目标 071. 本补充品的科学目标是开发 (1) 还原性交叉亲电子试剂 烷基吡啶鎓盐和(杂)芳基氯的偶联，以及(2)级联环化 烷基吡啶鎓盐与烯烃连接以产生一系列环状产物。 将容易获得的起始材料转化为生物活性分子中发现的有价值的基序。 这项研究将极大地磨练加西亚女士在催化方法开发方面的专业知识。 通过提供高通量实验经验来增强她的研究能力 (HTE)，与辉瑞公司药物化学家的合作互动和见解，以及 该补充提案还包括开发立体选择性转化的能力。 指导计划，包括参与特拉华大学的化学-生物界面项目、多个 课程和研讨会、教学和指导经验以及专业网络 机会，最大限度地提高加西亚女士的培训和未来的成功。