Bruker D8 VENTURE Diffractometer

布鲁克 D8 VENTURE 衍射仪

• 批准号: 10429832
• 负责人: Bo Li
• 金额: $ 42.83万
• 依托单位: BOSTON COLLEGE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10429832
• 关键词: 12 year old; Age; Area; Biochemistry; Biology; Boston; Charge; Chemicals; Consumption; Coupled; Crystallization; Data; Data Collection; Faculty; Funding; Light; Measurement; Methods; Modeling; Organic Chemistry; Production; Radiation; Research; Research Activity; Roentgen Rays; Sampling; Services; Source; Structure; Temperature; Time; United States National Institutes of Health; Work; X-Ray Crystallography; bioactive natural products; college; density; detector; drug candidate; experimental study; improved; instrument; member; programs; quantum; small molecule; tool

Project Summary/Abstract The Center for X-ray Crystallography at Boston College is seeking funds to purchase a Bruker D8 VENTURE Diffractometer coupled with duo ImuS radiation sources (Mo and Cu) and a PHOTON III detector for small molecule structural characterization. Currently the only single-crystal X-ray diffractometer at Boston College is an 12-year old Bruker APEX II DUO diffractometer purchased in 2009. This essential workhorse instrument has become unreliable with age and heavy usage. Due to discontinuation of production of this model instrument and a lack of replacement parts, Bruker will end service support for our current instrument starting June 1, 2021. The Bruker D8 VENTURE allows users to collect high-quality charge density data with Mo radiation and to exploit all the advantages of the Cu wavelength for absolute structure determinations and diffraction experiments on small organic crystals. This new instrument will provide indispensable analytical support for a very broad range of research programs from eight faculty members, among them, seven are NIH-supported. Research activities are concentrated primarily in the areas of synthetic organic chemistry, and biochemistry/chemical biology, targeted to develop methods for the synthesis of bioactive natural products, small molecule drug candidates, and macromolecular biomolecules. Such projects depend highly on the acquisition of structural information of intermediate and end products. X-ray crystallography is an indispensable tool for this work, and in many cases, the only reliable method to obtain structural information. The combination of ultra brightness of the ImuS sources, with the quantum-limited sensitivity of the PHOTON III detector, will not only greatly improve our capability on small and weakly-diffracted samples, but also fulfil the steadily rising needs for absolute configuration determinations on molecules that only contain light atoms. Users are more likely to get crystal structures from samples that were previously found to be unsuitable or too small. Time consuming experiments such as variable temperature measurements will become more practical and data collection on metastable crystals will be amenable, thanks to faster acquisition time.

项目概要/摘要 波士顿学院 X 射线晶体学中心正在寻求资金购买 Bruker D8 VENTURE 衍射仪与双 ImuS 辐射源（Mo 和 Cu）和 PHOTON III 探测器相结合，用于小型 分子结构表征。目前波士顿学院唯一的单晶X射线衍射仪是 一台 2009 年购买的已有 12 年历史的 Bruker APEX II DUO 衍射仪。这款重要的主力仪器具有 随着年龄和大量使用而变得不可靠。由于该型号仪器停产， 由于缺乏替换零件，布鲁克将从 2021 年 6 月 1 日起终止对我们当前仪器的服务支持。 Bruker D8 VENTURE 允许用户通过 Mo 辐射收集高质量电荷密度数据并利用 Cu 波长在绝对结构测定和衍射实验中的所有优点 小有机晶体。这种新仪器将为非常广泛的范围提供不可或缺的分析支持 八名教职人员的研究项目，其中七名是 NIH 支持的。研究活动 主要集中在合成有机化学和生物化学/化学生物学领域， 致力于开发生物活性天然产物、小分子候选药物的合成方法， 和大分子生物分子。此类项目高度依赖于结构信息的获取 中间产品和最终产品。 X 射线晶体学是这项工作不可或缺的工具，在许多情况下， 获取结构信息的唯一可靠方法。 ImuS 光源的超亮度组合， 凭借 PHOTON III 探测器的量子极限灵敏度，不仅会大大提高我们的能力 小且弱衍射的样品，同时也满足了稳定增长的绝对构型需求 对仅包含轻原子的分子的测定。用户更有可能从中获得晶体结构 以前发现不合适或太小的样本。耗时的实验，例如变量 温度测量将变得更加实用，亚稳态晶体的数据收集将变得更加容易 由于采集时间更快，因此可以接受。