Basic Science Core

基础科学核心

• 批准号: 10425949
• 负责人: Tanya Parish
• 金额: $ 22.37万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-21 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10425949
• 关键词: Address; Area; Basic Science; Biological Sciences; Biology; Child; Communities; Consultations; Development; Diagnostic; Educational Curriculum; Emergency Situation; Epidemic; Equipment; Foundations; Fred Hutchinson Cancer Research Center; Funding; Goals; Hour; Immune response; Immunology; Infection; Measures; Methods; Microbiology; Mycobacterium tuberculosis; Outcome; Output; Pathogenesis; Process; Research; Research Institute; Research Personnel; Research Project Grants; Resources; Scientist; Services; Talents; Technology; Thinking; Training; Treatment Protocols; Tuberculosis; Tuberculosis diagnosis; Universities; Vaccines; Washington; Work; accurate diagnostics; career; combat; experience; fight against; insight; interest; investigator training; next generation; novel strategies; novel therapeutics; pathogen; prevent; programs; recruit; research facility; skills; success; tool

PROJECT SUMMARY (BASIC SCIENCE CORE) Developing new drugs, vaccines, and diagnostics to combat the TB epidemic requires increased understanding of Mycobacterium tuberculosis pathogenesis. Achieving these goals will require an influx of new investigators trained in basic and advanced TB methods, as well as access to highly specialized facilities and equipment. The primary goal of the Basic Science Core is to provide the consultation and training necessary to equip investigators with the expertise and tools needed to advance the field. The Basic Science Core will focus on new investigators (NIs) at the start of their careers and more established scientists who are new to TB research. We will utilize the outstanding TB research facilities and equipment within Seattle, and leverage the complementary expertise of SEA-TRAC investigators at the University of Washington, Seattle Children’s Research Institute, and the Fred Hutchinson Cancer Research Center. In Aim 1, we will provide basic training to new investigators who seek access to the BSL3 to initiate new TB research programs. Our curriculum will be split into: Tier 1 -- basic BSL3 work with a dedicated BSL3 trainer; and Tier 2 -- hands-on, specialized training for either microbiology-focused or immunology-focused work. In Aim 2, we will provide a consultation service for new TB investigators with an interest in studying Mtb microbiology. We will advise regarding the best-suited approaches and technologies to address their specific pathogen-related research questions. Drawing from the broad expertise and resources of the Seattle TB research community, and working with the Development Core Pilot Program, we will also provide opportunities for in-depth training in a diverse suite of standard and advanced approaches to study Mtb biology. In Aim 3, we will develop a parallel program to the one in Aim 2, for new TB investigators with an interest in Mtb immunology. We will provide a consultation service to match the best-suited advanced approaches to address Mtb immunology research questions. We will also provide in-depth training in a broad range of cutting-edge technologies that target understanding the host response to Mtb. Altogether, these efforts will equip the next generation of TB investigators with the skills to generate scientific insights and help end the TB epidemic.

项目摘要（基础科学核心） 开发新药、疫苗和诊断方法来对抗结核病流行需要增加 了解结核分枝杆菌的发病机制将需要大量新的知识的涌入。 研究人员接受过基本和高级结核病方法培训，并可使用高度专业化的设施和 基础科学核心的主要目标是提供必要的咨询和培训。 基础科学核心将重点为研究人员提供推进该领域所需的专业知识和工具。 针对处于职业生涯初期的新研究者 (NI) 以及刚接触结核病的知名科学家 我们将利用西雅图优秀的结核病研究设施和设备，并利用 华盛顿大学西雅图儿童医院 SEA-TRAC 研究人员的专业知识互补 研究所和弗雷德·哈钦森癌症研究中心。 在目标 1 中，我们将为寻求访问 BSL3 以启动新的研究人员提供基本培训 我们的结核病研究项目将分为： 第 1 级——由专门的 BSL3 培训师进行的基本 BSL3 工作； 第二层——针对微生物学或免疫学工作的实践专业培训。 2、我们将为有兴趣研究结核菌微生物学的新结核病研究者提供咨询服务。 我们将建议最适合的方法和技术来解决与特定病原体相关的问题 研究问题。借鉴西雅图结核病研究界的广泛专业知识和资源，以及 与发展核心试点计划合作，我们还将提供深入培训的机会 在目标 3 中，我们将开发一套并行的研究 Mtb 生物学的标准和高级方法。 对于目标 2 中的项目，我们将为对 Mtb 免疫学感兴趣的新结核病研究人员提供一份。 咨询服务，以匹配最适合的先进方法来解决结核分枝杆菌免疫学研究 我们还将针对各种尖端技术提供深入的培训。 总而言之，这些努力将为下一代结核病做好准备。 研究人员有能力产生科学见解并帮助结束结核病流行。