UAB Cancer Prevention and Control Training Program (T32)

UAB癌症防治培训项目（T32）

基本信息

批准号：
10427303
负责人：
Ritu Aneja
金额：
$ 44.4万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-13 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10427303
关键词：
Cancer Control Training Programs cancer prevention

项目摘要

In 1988, the University of Alabama at Birmingham (UAB) Cancer Prevention and Control Training Program (CPCTP) was established under an R25 mechanism and has trained 154 pre- and post-doctoral fellows over the past 28 years. Located in the Deep South, an area marked by poverty and health disparities, the CPCTP provides a critical bridge for students from diverse and disadvantaged backgrounds who seek research careers in cancer prevention and control. Currently, 55% of CPCTP trainees are underserved minorities, and 65% are female. Consonant with NCI's mission to address the nation's behavioral, biomedical, and clinical research needs for a diverse workforce (PAR-16-152), we seek to transition our CPCTP to a T32 mechanism, so that we can continue to prepare a diverse pool of highly-trained scientists who have made a major career commitment to cancer prevention and control research (3 pre- & 3 post-doctoral fellows in years 1-2, and 4- pre & 4- post doctoral fellows in years 3-5, with a planned duration of 3-years for each appointment). Over 90% of graduates from our current cycle are actively engaged in research careers showing success. Our proposed T32 adds many novel components to the CPCTP, while retaining those that have been key to our success, e.g., our team science multidisciplinary approach and strong team mentorship from 32 faculty who are members of the Cancer Control and Population Sciences and Cancer Chemoprevention Programs of the UAB Comprehensive Cancer Center (CCC) - one of the nation's first 7 NCI-designated CCCs. Our efforts are supported by a solid financial commitment by the UABCCC and our proposed aims are to: 1) recruit, educate, train and evaluate pre- and postdoctoral fellows from diverse academic disciplines to conduct interdisciplinary research in cancer prevention and control; 2) recruit a diverse cadre of well-qualified trainees who include members of minority groups, (i.e., African-Americans, Latinos/ Hispanics, and other disadvantaged groups), and capitalize on UAB's networks and resources to promote research in health disparities within the framework of cancer prevention and control; 3)provide a specialized core didactic and tailored research curricula and rich learning opportunities in cancer prevention and control (e.g., seminars, grant preparation/mock reviews), that complement (not duplicate) other UAB training programs; 4) foster the development of independent research careers in cancer prevention and control through mentoring by senior faculty who have established track records in funded research; 5) further the development of all trainees via additional coursework, additional degrees (i.e., MSPH), and obtaining independent research fellowships or career awards (e.g., F31/32, K99, DP5); 6) educate our trainees in the Responsible Conduct of Research and in areas of professional development that will enhance their future successes in research careers at universities, private institutions, or within the federal government; and 7) emphasize interdisciplinary research training (team science) to enable trainees to gain competence in at least two research areas and enhance their future ability to collaborate with professionals in other areas.

1988年，阿拉巴马大学伯明翰分校（UAB）癌症预防与控制培训项目 CPCTP（CPCTP）是在R25机制下成立的，已培养了154名博士前和博士后研究员过去28年。 CPCTP 位于以贫困和健康差距为特征的南方腹地为来自不同背景和弱势背景、寻求研究职业的学生提供了一座重要的桥梁在癌症预防和控制方面。目前，55% 的 CPCTP 学员是服务不足的少数族裔，65% 是女性。符合 NCI 解决国家行为、生物医学和临床研究问题的使命为了满足多元化劳动力的需求 (PAR-16-152)，我们寻求将 CPCTP 过渡到 T32 机制，以便我们可以继续培养一批训练有素、做出重大职业承诺的多样化科学家癌症预防和控制研究（1-2 年 3 名博士前研究员和 3 名博士后研究员，以及 4- 博士前和 4- 博士后第 3-5 年为博士研究员，每次任命的计划期限为 3 年）。 90%以上毕业生从我们当前的周期来看，我们正在积极从事研究事业，并取得了成功。我们建议的 T32 增加了 CPCTP 的许多新颖组成部分，同时保留那些对我们成功至关重要的组成部分，例如我们的团队科学的多学科方法和来自 32 名教员的强有力的团队指导 UAB综合癌症控制与人口科学和癌症化学预防项目癌症中心 (CCC) - 全国首批 7 个 NCI 指定的 CCC 之一。我们的努力有坚实的支撑 UABCCC 的财务承诺和我们提出的目标是： 1) 招募、教育、培训和评估来自不同学科的博士前和博士后研究员开展癌症跨学科研究预防和控制； 2) 招募一支多元化的高素质学员骨干队伍，其中包括少数民族成员群体（即非裔美国人、拉丁裔/西班牙裔和其他弱势群体），并利用 UAB 促进癌症预防框架内健康差异研究的网络和资源和控制； 3）提供专业的核心教学和量身定制的研究课程以及丰富的学习机会在癌症预防和控制（例如研讨会、拨款准备/模拟审查）中，这种补充（不是重复）其他 UAB 培训计划； 4）促进癌症独立研究事业的发展通过在资助方面建立跟踪记录的高级教师的指导来进行预防和控制研究; 5) 通过额外的课程、额外的学位（即 MSPH）进一步促进所有学员的发展，并获得独立研究奖学金或职业奖项（例如，F31/32、K99、DP5）； 6）教育我们的负责任的研究行为和专业发展领域的受训人员将增强他们未来在大学、私人机构或联邦政府的研究生涯中取得的成功； 7) 强调跨学科研究培训（团队科学），使受训者能够获得以下方面的能力：至少两个研究领域，并增强他们未来与其他领域的专业人士合作的能力。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Strategies in Overcoming Homologous Recombination Proficiency and PARP Inhibitor Resistance.

克服同源重组能力和 PARP 抑制剂耐药性的策略。

DOI：
发表时间：
2021
期刊：
影响因子：
5.7
作者：
Goel, Nidhi;Foxall, McKenzie E;Scalise, Carly Bess;Wall, Jaclyn A;Arend, Rebecca C
通讯作者：
Arend, Rebecca C

Distance from a cultural model of substance use risk, internalization, and self-stigma in urban Brazil.

与巴西城市物质使用风险、内化和自我耻辱的文化模式的距离。

DOI：
发表时间：
2023
期刊：
影响因子：
0
作者：
Henderson, Nicole L;Dressler, William W;Pegoraro, Natália Priolli Jora;Falcão, Ana;Pillon, Sandra Cristin
通讯作者：
Pillon, Sandra Cristin

Immunophenotype-associated gene signature in ductal breast tumors varies by receptor subtype, but the expression of individual signature genes remains consistent.

导管性乳腺肿瘤中的免疫表型相关基因特征因受体亚型而异，但个体特征基因的表达保持一致。

DOI：
发表时间：
2021
期刊：
影响因子：
4
作者：
Behring, Michael;Ye, Yuanfan;Elkholy, Amr;Bajpai, Prachi;Agarwal, Sumit;Kim, Hyung;Ojesina, Akinyemi I;Wiener, Howard W;Manne, Upender;Shrestha, Sadeep;Vazquez, Ana I
通讯作者：
Vazquez, Ana I

To Disclose or Not to Disclose: A Case Highlighting the Challenge of Conflicts in Pediatric Disclosure.

披露还是不披露：一个凸显儿科披露冲突挑战的案例。