CARDIOVASCULAR RISK IN SLEEP APNEA--THE FRAMINGHAM STUDY

睡眠呼吸暂停的心血管风险——弗雷明汉研究

• 批准号: 2232090
• 负责人: GEORGE T O'CONNOR
• 金额: $ 37.92万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2232090
• 关键词: CARDIOVASCULAR; RISK; SLEEP; APNEA; FRAMINGHAM

Sleep-disordered breathing (SDB) refers to a spectrum of respiratory disturbances during sleep which ranges from snoring unaccompanied by functional disturbances to clinically overt obstructive sleep apnea syndrome. SDB has been implicated as a risk factor for the development of hypertension, ischemic heart disease, and cerebral infarction. It remains uncertain whether the risk of vascular disease associated with SDB exists independent of other known vascular disease risk factors, and if so, by what physiologic mechanisms. The association of SDB with increased sympathetic nervous system activity, which has potentially important adverse effects on blood pressure, left ventricular mass, lipid profile, platelet function, and atherogenesis, suggests a plausible mechanism for an independent adverse effect of SDB on the risk of cardiac, cardiovascular, and cerebrovascular disease (collectively, CVD). We propose to evaluate the independent contribution of SDB to the risk of CVD, and to study the mechanisms underlying this risk by means of a prospective longitudinal cohort study. This study will be conducted in the well-characterized Offspring Cohort, and a newly recruited Minority Cohort, of the Framingham Heart Study, as part of a larger collaborative study of the cardiovascular consequences of sleep apnea. We will address the following specific aims, (1.) Determine the risk of cardiovascular and cerebrovascular disease associated with SDB, independent of other known risk factors for CVD. (2.) Assess potential interactions between SDB and other known CVD risk factors in relation to CVD risk. (3.) Examine the contribution of SDB to the development of other CVD risk factors. (4.) Identify population subgroups at greatest risk of CVD from SDB. (5.) Estimate the effect of SDB on quality of life and utilization of health care resources. (6.) Test the hypothesis that isolated REM-associated SDB is a risk factor for CVD. (7.) Test the hypothesis that SDB increases the risk of CVD by increasing the activity of the sympathetic nervous system. (8.) Test the hypothesis that level of ventilatory function, as measured by spirometry, modifies the risk of CVD associated with SDB.

睡眠呼吸呼吸（SDB）是指一系列呼吸系统 睡眠期间的骚乱范围从无人陪伴的呼吸范围 对临床明显阻塞性睡眠呼吸暂停的功能性干扰 综合征。 SDB已被视为发展的风险因素 高血压，缺血性心脏病和脑梗塞。它仍然存在 不确定是否存在与SDB相关的血管疾病的风险 独立于其他已知的血管疾病危险因素，如果是的，则 什么生理机制。 SDB的关联随增加 交感神经系统活动，这可能很重要 对血压的不利影响，左心室肿块，脂质谱， 血小板功能和动脉粥样硬化提出了一种合理的机制 SDB对心脏风险的独立不利影响， 心血管疾病和脑血管疾病（统称为CVD）。我们 建议评估SDB对风险的独立贡献 CVD，并研究通过 前瞻性纵向队列研究。这项研究将在 特征良好的后代队列和新招募的少数民族 弗雷明汉心脏研究的同类人群，作为更大的合作的一部分 睡眠呼吸暂停的心血管后果的研究。 我们将解决以下特定目标，（1。）确定 与SDB相关的心血管和脑血管疾病， 与CVD的其他已知危险因素无关。 （2.）评估潜力 SDB与其他已知的CVD风险因素之间的相互作用有关 CVD风险。 （3.）检查SDB对发展的贡献 其他CVD风险因素。 （4.）确定最大的人口亚组 SDB的CVD风险。 （5.）估计SDB对生活质量的影响 和利用医疗保健资源。 （6.）检验孤立的REM与SDB是危险因素的假设 对于CVD。 （7.）检验以下假设：SDB增加了CVD的风险 增加交感神经系统的活性。 （8.）测试 假设通过肺活量测定法测量的通气功能水平 修改与SDB相关的CVD风险。