XtremeCT II high-resolution peripheral quantitative computed tomography (HR-pQCT) scanner

XtremeCT II 高分辨率外周定量计算机断层扫描 (HR-pQCT) 扫描仪

• 批准号: 10420213
• 负责人: Ashley Weaver
• 金额: $ 43.75万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-15 至 2024-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10420213
• 关键词: Address; Adult; Advisory Committees; Aging; Applications Grants; Architecture; Biological; Bone Density; Chronic Kidney Failure; Computed Tomography Scanners; Computer Models; Development; Diabetes Mellitus; Diet; Elderly; Exercise; Fostering; Fracture; Funding; Genomics; Health; Image Analysis; Imaging Device; Incidence; Injury; Institutes; Interdisciplinary Study; Intervention; Investigation; Leadership; Life Style; Longevity; Minor; Musculoskeletal; Outcome; Peripheral; Population Heterogeneity; Proteins; Radiation; Rehabilitation therapy; Research; Resolution; Role; Skeletal Muscle; Skeleton; System; Techniques; Technology; United States National Institutes of Health; Vehicle crash; Weight; Weight maintenance regimen; Weight-Bearing state; X-Ray Computed Tomography; age related; base; biomedical imaging; bone; bone health; bone imaging; bone loss; bone strength; comorbidity; cost effectiveness; ethnic diversity; forest; fracture risk; imaging modality; imaging program; insight; instrument; medical schools; novel; skeletal; success; treatment strategy

Project Abstract In this Shared Instrument Grant application, we are requesting funds to acquire an XtremeCT II High Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) scanner. HR-pQCT is a non-invasive, low radiation approach for assessing compartment-specific volumetric bone mineral density (vBMD) and bone microarchitecture in the peripheral skeleton to estimate bone strength and fracture risk. Integration of this state- of-the-art skeletal imaging modality into the repertoire of biomedical imaging tools available at Wake Forest School of Medicine (WFSM) advances the initiatives of 18 NIH-funded centers, institutes, and departments; and bolsters collaborative efforts with several of our regional partners. Specifically, acquisition of HR-pQCT technology will allow the proposed major and minor user groups to: 1) better understand the effects of lifestyle- based strategies — such as weight-bearing exercise and a high protein diet — on skeletal health among older adults losing weight; 2) expand the investigation of the role of age-related biological changes in skeletal muscle on the decline in mobility to include interactions with bone; 3) demonstrate the potential of advanced image analyses techniques to augment histostructural outcomes; 4) provide insight into the genomic architecture of bone health to aid in the development of novel treatment strategies to mitigate bone loss in aging; 5) better capture musculoskeletal comorbidities among motor vehicle crash occupants, and understand their influence on injury incidence and rehabilitation success; 6) address important gaps on the effects of weight management interventions on the growing skeleton; 7) evaluate whether bone microarchitecture varies across ethnically diverse populations; 8) augment computational modeling strategies assessing change in bone health across the lifespan to include bone microarchitecture and strength; and 9) determine the timing of and extent to which intracortical bone loss occurs among adults with diabetes mellitus and chronic kidney disease. To promote cost effectiveness, encourage optimal sharing, and foster multidisciplinary collaborations, the HR-pQCT will be housed in the Translational Imaging Program Core at WFSM, where it will be overseen by qualified leadership, operational, and advisory committees in accordance with well-organized and self-sustaining administrative and financial plans. Ultimately, the addition of a HR-pQCT system will enable WFSM to engage in more multidisciplinary collaborations, compete more successfully for external research funding, and remain at the forefront of musculoskeletal research endeavors.

项目摘要 在此共享仪器拨款申请中，我们请求资金来购买 XtremeCT II High 分辨率外围定量计算机断层扫描 (HR-pQCT) 扫描仪是一种非侵入性、 用于评估特定骨室体积骨矿物质密度 (vBMD) 和骨的低辐射方法 周围骨骼中的微结构来评估骨强度和骨折风险。 将最先进的骨骼成像模式纳入维克森林大学提供的生物医学成像工具库中 医学院 (WFSM) 推动 18 个 NIH 资助的中心、研究所和部门的举措； 加强与我们几个区域合作伙伴的合作，特别是收购 HR-pQCT。 技术将使拟议的主要和次要用户群体能够：1）更好地了解生活方式的影响- 基于老年人骨骼健康的策略（例如负重运动和高蛋白饮食） 成年人减肥；2）扩大骨骼肌中与年龄相关的生物学变化的作用的研究 移动能力下降，包括与骨骼的相互作用；3）展示高级图像的潜力 分析增强组织结构结果的技术；4) 提供对基因组结构的深入了解； 骨骼健康有助于开发新的治疗策略，以减轻衰老过程中的骨质流失；5) 捕捉机动车辆事故乘员的肌肉骨骼合并症，并了解其对 受伤发生率和康复成功；6）解决体重管理效果方面的重要差距 对骨骼生长的干预措施；7）评估骨微结构是否因种族而异 8）增强评估整个人群骨骼健康变化的计算模型策略 寿命，包括骨微结构和强度；9) 确定骨微结构和强度的时间和程度； 患有糖尿病和慢性肾病的成年人会发生皮质内骨质流失，从而增加成本。 HR-pQCT 将提高有效性、鼓励最佳共享并促进多学科合作 位于 WFSM 的转化成像项目核心，将由合格的领导层监督， 业务和咨询委员会根据组织良好和自我维持的行政和 最终，增加 HR-pQCT 系统将使 WFSM 能够参与更多工作。 多学科合作，更成功地竞争外部研究资金，并保持在 肌肉骨骼研究领域的前沿。