SLEEP APNEA AND HYPERTENSION--ROLE OF NERVOUS SYSTEM

睡眠呼吸暂停和高血压——神经系统的作用

• 批准号: 2221760
• 负责人: JOEL E DIMSDALE
• 金额: $ 36.22万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2221760
• 关键词: angiotensin /renin /aldosterone hypertension; atrial natriuretic peptide; baroreceptors; behavioral medicine; beta adrenergic receptor; blood chemistry; blood pressure; cortisol; hormone regulation /control mechanism; human subject; hypertension; hypoxia; isoproterenol; neuropeptide Y; neurotransmitter metabolism; norepinephrine; psychological stressor; sleep; sleep apnea; sympathetic nervous system; urinalysis; wakefulness

There is a high co-morbidity between sleep apnea and essential hypertension. This study will test the hypothesis that apneic episodes predispose to hypertension by repeated nighttime arousals that raise blood pressure to daytime levels via activation of the sympathetic nervous system and release of stress hormones. Plasma and urinary catecholamines, renin, neuropeptide Y, atrial natriuretic factor, blood pressure, and cortisol will be examined during sleep, resting wakefulness, and after mild behavioral stressors. Beta adrenergic receptors on lymphocytes and the response to adrenergic agonists will be characterized. This study will determine if apneic hypertensives have an excessive response to the stress of hypoxia or to combined hypoxia plus breathholding. Mild hypoxia will be induced, and the effects of hypoxia will be examined on norepinephrine metabolism, baroreceptor functioning, and sensitivity to infused isoproterenol. Eighty unmedicated patients will be studied: 20 hypertensives with sleep apnea, 20 hypertensives without apnea, 20 normotensives with sleep apnea, and 20 normotensives without apnea. All patients will be admitted for a 2 day stay in the Clinical Research Center.

睡眠呼吸暂停与原发性呼吸暂停之间存在很高的共存率 高血压。 这项研究将检验呼吸暂停发作的假设 夜间反复觉醒导致血液升高，易患高血压 通过激活交感神经系统将压力降至白天水平 和压力荷尔蒙的释放。 血浆和尿儿茶酚胺、肾素、神经肽 Y、心房 期间将检查利尿钠因子、血压和皮质醇。 睡眠、休息清醒时以及轻微行为压力之后。 贝塔 淋巴细胞上的肾上腺素受体和对肾上腺素激动剂的反应 将被表征。 这项研究将确定呼吸暂停高血压是否有过度的 对缺氧应激或联合缺氧的反应 屏住呼吸。 会引起轻度缺氧，缺氧的影响 将检查去甲肾上腺素代谢、压力感受器功能、 和对输注异丙肾上腺素的敏感性。 将研究 80 名未接受药物治疗的患者：20 名患有睡眠高血压的患者 呼吸暂停，20 名无呼吸暂停的高血压患者，20 名患有睡眠呼吸暂停的正常血压患者， 20 次血压正常，无呼吸暂停。 所有患者均将入院接受 2 在临床研究中心停留一天。