SLEEP APNEA AND HYPERTENSION--ROLE OF NERVOUS SYSTEM

睡眠呼吸暂停和高血压——神经系统的作用

• 批准号: 2221760
• 负责人: JOEL E DIMSDALE
• 金额: $ 36.22万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2221760
• 关键词: angiotensin /renin /aldosterone hypertension; atrial natriuretic peptide; baroreceptors; behavioral medicine; beta adrenergic receptor; blood chemistry; blood pressure; cortisol; hormone regulation /control mechanism; human subject; hypertension; hypoxia; isoproterenol; neuropeptide Y; neurotransmitter metabolism; norepinephrine; psychological stressor; sleep; sleep apnea; sympathetic nervous system; urinalysis; wakefulness

There is a high co-morbidity between sleep apnea and essential hypertension. This study will test the hypothesis that apneic episodes predispose to hypertension by repeated nighttime arousals that raise blood pressure to daytime levels via activation of the sympathetic nervous system and release of stress hormones. Plasma and urinary catecholamines, renin, neuropeptide Y, atrial natriuretic factor, blood pressure, and cortisol will be examined during sleep, resting wakefulness, and after mild behavioral stressors. Beta adrenergic receptors on lymphocytes and the response to adrenergic agonists will be characterized. This study will determine if apneic hypertensives have an excessive response to the stress of hypoxia or to combined hypoxia plus breathholding. Mild hypoxia will be induced, and the effects of hypoxia will be examined on norepinephrine metabolism, baroreceptor functioning, and sensitivity to infused isoproterenol. Eighty unmedicated patients will be studied: 20 hypertensives with sleep apnea, 20 hypertensives without apnea, 20 normotensives with sleep apnea, and 20 normotensives without apnea. All patients will be admitted for a 2 day stay in the Clinical Research Center.

睡眠呼吸暂停和必不可 高血压。 这项研究将检验呼吸暂停发作的假设 通过反复的夜间唤醒易于高血压，唤起血液 通过激活交感神经系统的压力到白天水平 并释放应力激素。 等离子体和尿液儿茶酚胺，肾素，神经肽Y，心房 在 睡眠，保持清醒以及轻度行为压力之后。 beta 淋巴细胞上的肾上腺素能受体和对肾上腺素能激动剂的反应 将被描述。 这项研究将确定呼吸高压是否过多 对缺氧或缺氧合并的应力反应 呼吸。 轻度缺氧将被诱导，缺氧的影响 将在去甲肾上腺素代谢，压力感受器功能上进行检查， 对注入的异丙肾上腺素的敏感性。 将研究八十名未药物的患者：20种睡眠高血压 呼吸暂停，20种无呼吸暂停的高血压，20种与睡眠呼吸暂停的正常敏化剂， 和20种无呼吸暂停的正常敏化剂。 所有患者将被录取2 一天留在临床研究中心。