CONVERTING ENZYME INHIBITION & CARDIOVASCULAR REACTIVITY

转化酶抑制

• 批准号: 3357194
• 负责人: JOEL E DIMSDALE
• 金额: $ 16.79万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-29 至 1993-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3357194
• 关键词: ACE inhibitors; aldosterone; angiotensin /renin /aldosterone hypertension; angiotensin II; atrial natriuretic peptide; baroreceptors; blood pressure; captopril; cardiovascular pharmacology; catecholamines; clinical chemistry; computer data analysis; diet; dietary sodium; dosage; environment associated hypertension; heart rate; human subject; hydralazine; male; norepinephrine; nutrition related tag; peptidyl dipeptidase A; psychological stressor; psychometrics; radioimmunoassay; renin; salt intake; saluresis; sodium; stress; sympathetic nervous system

This study examines the effect of angiotensin converting enzyme inhibition and dietary salt on physiological responses to behavioral stressors. It is difficult to tease apart the roles of the sympathetic nervous system, the renin-angiotensin system, and dietary salt. For instance, under low salt conditions, there is activation of both the sympathetic nervous system and the renin- angiotensin system. As a result, observing an increased pressor response to stressors in patients on high salt intake is not straightforward. A beginning way to understand this system is to block production of angiotensin II with an angiotensin covering enzyme inhibitor (captopril). Thirty hypertensive and 30 normotensive white men will be admitted for two 5-day hospitalizations on a Clinical Research Center while they consume a low salt diet (10 meq/d). These subjects will participate in a randomized crossover design employing either placebo on the initial hospitalization or captopril. Patients will be studied at rest, while they are exposed to behavioral stressors, and during infusions of norepinephrine. The following physiological variables will be monitored: blood pressure, heart rate, plasma and urinary catecholamines, renin, aldosterone, angiotensin II, atrial natriuretic factor, urinary sodium, and the slope of the dose response curve relating infused norepinephrine to blood pressure. The investigators will also have obtained data from another project on an additional 60 subjects, studied on the same reactivity protocol, but who are hospitalized on a high salt diet (200 meq/d). The reactivity of these subjects will be compared to that elicited by other subjects on a combination of salt depletion plus captopril. Thus the effects of salt intake will be studied while blocking the activation of the renin-angiotensin system on the low salt diet.

这项研究检查了血管紧张素转化酶的作用 抑制和饮食盐对行为的生理反应 压力源。 很难取笑 交感神经系统，肾素 - 血管紧张素系统和 饮食盐。 例如，在低盐条件下，有 激活交感神经系统和肾素 - 血管紧张素系统。 结果，观察增加的压力 对高盐摄入患者的压力源的反应不是 直截了当。 理解该系统的一种开始方法是 具有血管紧张素覆盖的血管紧张素II的阻滞产生 酶抑制剂（卡托普利）。 三十多名高血压和30名普通的白人将是 接受了两次为期5天的临床研究的住院 中心，而他们消耗低盐饮食（10 meq/d）。 这些 受试者将参加随机跨界设计 在初始住院或 卡托普利。 患者将在休息时进行研究，同时 行为应力源以及去甲肾上腺素的输注期间。 这 将监测以下生理变量：血液 压力，心率，等离子体和尿尿胺，肾素， 醛固酮，血管紧张素II，心房尿素，尿液 钠和剂量响应曲线的斜率与注入 去甲肾上腺素到血压。 调查人员还将从另一个 对另外60个主题进行了项目，同样的研究 反应性方案，但在高盐饮食中住院 （200 meq/d）。 这些受试者的反应性将被比较 其他受试者在盐耗尽的组合中引起了这种情况 加上卡托普利。 因此，将研究盐摄入的影响 同时阻止肾素 - 血管紧张素系统的激活 低盐饮食。

项目成果

Renin correlates with blood pressure reactivity to stressors.

肾素与血压对压力源的反应相关。

• 发表时间: 1990
• 期刊: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
• 作者: Dimsdale,JE;Ziegler,M;Mills,P
• 通讯作者: Mills,P

The effects of caffeine on blood pressure in the work environment.

咖啡因对工作环境中血压的影响。

• DOI: 10.1093/ajh/3.10.749
• 发表时间: 1990
• 期刊: American journal of hypertension
• 影响因子: 3.2
• 作者: Jeong,DU;Dimsdale,JE
• 通讯作者: Dimsdale,JE

The effects of acute psychologic stress on cellular adhesion molecules.

急性心理应激对细胞粘附分子的影响。

• DOI: 10.1016/0022-3999(96)00051-7
• 发表时间: 1996
• 期刊: Journal of psychosomatic research
• 影响因子: 4.7
• 作者: Mills,PJ;Dimsdale,JE
• 通讯作者: Dimsdale,JE

A quantitative technique for characterizing tasks in psychophysiology studies.

用于表征心理生理学研究中的任务的定量技术。

• DOI: 10.1097/00006842-199007000-00005
• 发表时间: 1990
• 期刊: Psychosomatic medicine
• 影响因子: 3.3
• 作者: Dimsdale,JE;Berry,C;Mills,P
• 通讯作者: Mills,P

Race and sex differences in cardiovascular recovery from acute stress.

急性应激后心血管恢复的种族和性别差异。

• DOI: 10.1016/0167-8760(96)00041-4
• 发表时间: 1996
• 期刊: International journal of psychophysiology : official journal of the International Organization of Psychophysiology
• 作者: Gillin,JL;Mills,PJ;Nelesen,RA;Dillon,E;Ziegler,MG;Dimsdale,JE
• 通讯作者: Dimsdale,JE