Center for Advancing Multimorbidity Science: Profiling risk and symptom expression to develop customized therapies for adults with multiple chronic conditions (CAMS)

促进多发病科学中心：分析风险和症状表达，为患有多种慢性病的成人开发定制疗法 (CAMS)

• 批准号: 10416005
• 负责人: KEELA A HERR
• 金额: $ 20.1万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-13 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10416005
• 关键词: Adult; Collaborations; Common Data Element; Data Analyses; Development; Discipline of Nursing; Electronic Health Record; Ensure; Faculty; Fatigue; Fostering; Foundations; Funding; Future; Grant; Healthcare; Intervention; Measurement; Mentors; Mentorship; Methodology; Nurses; Nursing Faculty; Pain; Pilot Projects; Postdoctoral Fellow; Progress Reports; Recommendation; Records; Research; Research Personnel; Research Project Grants; Resources; Risk; SF-36; Science; Scientist; Series; Service provision; Source; Symptoms; Techniques; Testing; Training; Translating; Universities; Well in self; Writing; career; college; data harmonization; data integration; data management; data quality; data sharing; data standards; effectiveness evaluation; experience; improved; individualized medicine; member; multiple chronic conditions; novel; programs; skill acquisition; skills; skills training; success; training opportunity

The Pilot Administrative Core seeks to increase the number and quality of independent, externally funded investigators who advance the science on adults with MCC, using risk profiling to support surveillance and anticipation of symptom experience so that customized therapies can be developed and tested. It will be responsible to 1) arrange and preside over scientific merit review of pilot projects, 2) ensure that advising and oversight plans are followed, 3) evaluate the effectiveness of mentoring plans in preparing Pilot PIs for independent research careers, 4) maintain records of pilot proposal reviews and ensure completion of annual progress reports of all funded pilots, 5) guide the pilot projects in fostering future collaborations and R-series grants that will translate into therapies and interventions, 6) facilitate dissemination of pilot project findings, 7) make recommendations to the Internal Executive Committee on pilot project funding decisions and regarding the termination or corrective actions for pilot projects, and 8) along with the Integrative Analytics Core and Enrichment Program, promote training opportunities within the Center and with the College and University. The Pilot Administrative Core has four specific aims: 1. Efficiently and effectively administer the pilot project program within the Center, including the selection and implementation of meritorious pilot projects. 2. Provide strong mentorship through a mentoring team for each Pilot PI that includes guidance in grant management, research team collaboration, methodology, measurement, data management and analyses, scientific writing, grant development, survival skills training, and mentorship skill development. 3. Ensure data harmonization through the incorporation of the Common Data Elements (CDE), including the NINR demographic CDEs and at least two of the required CDEs (PROMIS-Pain, PROMIS-Fatigue, and Psychological well-being-SF-36) into the aims of each Pilot Project. 4. Coordinate advanced training in emerging analytical techniques with the Integrative Analytic Core to expand and enrich the research skills of Pilot PIs and their research teams and increase the number of nursing faculty with expertise in traditional and novel research leading to customized therapies. These functions are essential for the successful transition of Pilot PIs into independent researchers and for facilitation of data sharing and standardization to improve data quality and enable data integration from multiple studies and sources, including electronic health records. We are convinced that systematic provision of these services is needed for the successful completion of the Center's research projects.

试点行政核心旨在提高独立外部人员的数量和质量 资助研究人员推进成人 MCC 的科学研究，利用风险分析来支持 监测和预测症状经历，以便开发定制疗法 已测试。负责：1）安排和主持试点项目的科学论证，2） 确保遵循建议和监督计划，3) 评估指导计划的有效性 为独立研究事业准备试点 PI，4) 保存试点提案审查记录和 确保完成所有资助试点的年度进度报告，5）指导试点项目培育 未来的合作和 R 系列赠款将转化为治疗和干预措施，6) 促进 传播试点项目的结果，7) 向内部执行委员会提出建议 试点项目资助决定以及有关试点项目终止或纠正措施的决定，以及 8) 与综合分析核心和强化计划一起，促进内部培训机会 中心以及学院和大学。试点管理核心有四个具体目标： 1. 高效、有效地管理中心内的试点项目计划，包括 选择和实施有功试点项目。 2. 通过指导团队为每个试点 PI 提供强有力的指导，包括拨款指导 管理、研究团队协作、方法、测量、数据管理和 分析、科学写作、资助开发、生存技能培训和指导技能 发展。 3. 通过纳入通用数据元素 (CDE) 确保数据协调， 包括 NINR 人口统计 CDE 和至少两个所需的 CDE（PROMIS-Pain、 PROMIS-疲劳和心理健康-SF-36）纳入每个试点项目的目标。 4. 协调新兴分析技术与综合分析核心的高级培训，以 扩大和丰富试点PI及其研究团队的研究技能，增加数量 护理人员拥有传统和新颖研究方面的专业知识，可实现定制疗法。 这些职能对于试点 PI 成功过渡为独立研究人员和 促进数据共享和标准化，提高数据质量并实现数据集成 来自多项研究和来源，包括电子健康记录。我们坚信，系统化的 成功完成该中心的研究项目需要提供这些服务。