MUSCLE: MUsculoSkeletal Clinical Learning Experience Transdisciplinary Musculoskeletal Research Training Program

肌肉：肌肉骨骼临床学习体验跨学科肌肉骨骼研究培训计划

• 批准号: 10410848
• 负责人: J. Kent Leach
• 金额: $ 17.98万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410848
• 关键词: Clinical; Learning; Musculoskeletal; Research Training; Training Programs; experience

PROJECT SUMMARY Within the United States, musculoskeletal disease affects more than half of people aged 18 and over and nearly three out of four aged 65 and over. The impact of musculoskeletal disease will become even more pronounced with the increase in the aging population. Mechanistic research that is integrated with clinical need is imperative to develop new treatment approaches, yet there is a stark mismatch between funding levels in musculoskeletal research and its financial and personal toll on our healthcare system. Our institution and the orthopaedic community, due to a lack of integrated programs, have struggled to overcome the disconnect between mechanistic research in musculoskeletal health and effective translation into the clinic. We developed the MUsculoSkeletal Clinical Learning Experience (MUSCLE) T32 Transdisciplinary Training Program at UC Davis to meet this need. The overall objective of this training program is to increase the number of biomedical scientists trained in musculoskeletal-related research with an emphasis on understanding clinical needs and obstacles. A novel aspect of our program is the frequent interaction and integration of premier musculoskeletal research faculty with leading clinicians at UC Davis, coupled with co-mentorship by mechanistic and clinical scientists, providing an elite training experience for future researchers in musculoskeletal health. The objective of the MUSCLE T32 is to provide two years of funded, transdisciplinary, integrated research training to develop predoctoral students into researchers capable of solving issues relevant to the understanding, prevention, and treatment of musculoskeletal diseases. This unique and integrated format benefits from co-directorship by mechanistic and clinical researchers alike, coordinating a select group of exemplary engineers, biologists, materials scientists, veterinarians, and human clinicians to co-mentor our students, in combination with a carefully designed, flexible curriculum that provides in-depth training for predoctoral students in musculoskeletal health research. With the recruitment of 3 new participants each year, trainees will partake in several clinical immersive experiences, where they will discuss the needs of the clinician and how research advancements can address these challenges. Our program emphasizes fundamentals in research techniques that broaden research training at the bench with quantitative skills, provides opportunities for public speaking and outreach, builds proposal writing skills, provides a range of enriching extracurricular opportunities, and integrates medicine and science/engineering throughout all years of training. Defined oversight mechanisms are in place to track the progress of the 15 trainees throughout the program. By training in an environment and culture that gives strong interdisciplinary support for mechanistic research and frequent clinical engagement, there is a significant probability that the trainees will sustain an interest in musculoskeletal health research over their careers.

项目概要 在美国，超过一半的 18 岁及以上人口患有肌肉骨骼疾病 四分之三的人年龄在 65 岁及以上。肌肉骨骼疾病的影响将变得更加明显 随着人口老龄化的增加。结合临床需求的机理研究势在必行 开发新的治疗方法，但肌肉骨骼领域的资金水平之间存在明显的不匹配 研究及其对我们的医疗保健系统造成的财务和个人损失。我们的机构和骨科 由于缺乏综合计划，社区一直在努力克服之间的脱节 肌肉骨骼健康的机制研究及其有效转化为临床。我们开发了 加州大学戴维斯分校 MUsculoSkeletal 临床学习体验 (MUSCLE) T32 跨学科培训计划 以满足这一需求。该培训计划的总体目标是增加生物医学科学家的数量 接受过肌肉骨骼相关研究培训，重点是了解临床需求和障碍。一个 我们项目的新颖之处在于顶级肌肉骨骼研究的频繁互动和整合 加州大学戴维斯分校顶尖临床医生的教职人员，加上机械科学家和临床科学家的共同指导， 为未来的肌肉骨骼健康研究人员提供精英培训经验。该计划的目标 MUSCLE T32 将提供两年的资助、跨学科、综合研究培训，以开发 博士前学生转变为能够解决与理解、预防和预防相关问题的研究人员 肌肉骨骼疾病的治疗。这种独特的综合格式受益于联合董事 机械和临床研究人员等，协调一组精选的模范工程师、生物学家， 材料科学家、兽医和人类临床医生共同指导我们的学生，并结合 精心设计、灵活的课程，为博士前学生提供肌肉骨骼方面的深入培训 健康研究。每年招募 3 名新学员，学员将参加多个临床项目 身临其境的体验，他们将讨论临床医生的需求以及研究进展如何 应对这些挑战。我们的课程强调拓宽研究范围的研究技术基础 在替补席上进行定量技能培训，提供公开演讲和外展机会，建立 提案写作技巧，提供一系列丰富的课外机会，并将医学和 科学/工程贯穿所有年份的培训。已制定明确的监督机制来跟踪 15 名学员在整个计划中的进展情况。通过在能够赋予强大力量的环境和文化中进行培训 对机械研究和频繁临床参与的跨学科支持，有显着的意义 学员在其职业生涯中保持对肌肉骨骼健康研究兴趣的可能性。