Clinical Core

临床核心

基本信息

批准号：
10407979
负责人：
DOUGLAS R GALASKO
金额：
$ 114.83万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10407979
关键词：
Address Adopted Age Aging Alzheimer&apos s Disease Area Autopsy Biochemical Biological Markers Biopsy Blood Blood specimen Brain Brain Chemistry Brain Pathology Brain imaging Cells Cessation of life Classification Clinical Clinical Research Clinical Trials Cognition Cognitive Cognitive aging Consent DNA Data Data Set Data Store Databases Dementia Diagnosis Disease Early Diagnosis Elderly Enrollment Environment Excision Funding Genetic Heterogeneity Hippocampus (Brain)Human Microbiome Image Latino Latino Population Lewy Body Disease Link Magnetic Resonance Imaging Measures Medical Genetics Memory Methodology Mexican Americans Neurodegenerative Disorders Participant Pathology Persons Phenotype Physiological Plasma Pluripotent Stem Cells Population Positron-Emission Tomography Quality Control Registries Research Research Support Sampling Skin Spinal Puncture Staging Structure Symptoms Temporal Lobe Testing United States National Institutes of Health Variant Work aging brain alpha synuclein biomarker evaluation brain magnetic resonance imaging cell transformation clinical phenotype clinically significant cognitive testing cohort data management data sharing dementia risk follow-up hazard hippocampal sclerosis imaging genetics indexing induced pluripotent stem cell innovation interest meetings member metabolomics mild cognitive impairment minority subjects neuropathology novel novel marker outreach pre-clinical ranpirnase recruit response social symposium tau Proteins volunteer

项目摘要

CLINICAL CORE SUMMARY/ ABSTRACT The primary aim of the Clinical Core will be to enroll, characterize and follow a cohort maintained at 500-600 elders to support many types of research into Alzheimer’s Disease and Related Disorders. People who are enrolled will include some with normal cognition, some of whom may have markers of Alzheimer’s in their brain already, people with mild cognitive impairment and mild Alzheimer’s, and people with other types of neurodegenerative disorders, including Lewy Body Disease and Fronto-Temporal Lobar Degeneration. The core will enroll minority subjects as part of the groups that are followed, in particular Latinos. In addition to collecting and storing data about the ADRC participants at UCSD, the core will include components that are part of a national effort across centers, called the Uniform Data Set (UDS). The Core will submit UDS data on all subjects it follows to the national Alzheimer’s Coordinating Center (NACC). This will allow data sharing with a large national database. The Clinical Core will perform further testing beyond the tests required for the UDS. The core will draw a sample of blood for DNA, plasma and serum from participants, and will obtain CSF samples by lumbar puncture from those who agree. The core will obtain skin biopsies to be used to transform the cells in the skin into cells that can change into many identities (called pluripotent stem cells). Participants will have MRI brain imaging and PET imaging to support research into brain changes and pathology. Blood, CSF, skin biopsies and imaging will be stored at UCSD to allow for further analysis, and it may be available to share with collaborators. All participants will be invited to undergo follow-up research assessments once per year, to determine change in brain functioning, memory and other abilities. In subjects who consent, after their death the core will arrange for autopsy removal of the brain, for pathology analysis and to support further research. Some of the particular areas where the core will focus its efforts are in novel cognitive tests and assessing the brain through biomarkers related to structure, function, pathology and chemistry of the brain. This may help in early detection of change before major symptoms of dementia have arisen. Alzheimer’s disease has different features and progresses at varying rates, and we will try to identify factors that may account for this variation. Another area of interest for the core is in developing better ways to assess Latino participants, supported through social, cultural, and research expertise of the Latino Core. Finally, the core will work with other members of the ADRC to maintain and expand a Registry of research- ready volunteers.

临床核心总结/摘要临床核心的主要目标是招募、描述和跟踪维持在 500-600 人的队列老年人支持对阿尔茨海默病和相关疾病的多种类型的研究。登记的人中包括一些认知能力正常的人，其中一些人的大脑中可能有阿尔茨海默氏症的标记患有轻度认知障碍和轻度阿尔茨海默氏症的人以及患有其他类型的人神经退行性疾病，包括路易体病和额颞叶变性。核心将招募少数民族受试者作为后续群体的一部分，特别是拉丁裔。除了收集和存储 UCSD 的 ADRC 参与者的数据外，核心还包括这些组件是国家跨中心工作的一部分，称为统一数据集（UDS）。将其跟踪的所有受试者的 UDS 数据提交给国家阿尔茨海默病协调中心 (NACC)。允许与大型国家数据库共享数据。临床核心将执行超出范围的进一步测试。 UDS 所需的测试。核心将从参与者身上抽取DNA、血浆和血清样本，并获取脑脊液核心将通过腰椎穿刺从同意的人身上获取皮肤活检样本，用于转化。将皮肤中的细胞转化为可以改变多种身份的细胞（称为多能干细胞）。将进行 MRI 脑成像和 PET 成像来支持脑变化和血液病理学研究。脑脊液、皮肤活检和成像将存储在加州大学圣地亚哥分校，以便进行进一步分析，并且可能可供与合作者分享。所有参与者将被邀请每年进行一次后续研究评估，以确定在同意的受试者死后，大脑功能、记忆力和其他能力会发生变化。安排尸检切除大脑，进行病理分析并支持进一步的研究。核心将重点关注的一些特定领域是新颖的认知测试和评估通过与大脑的结构、功能、病理学和化学相关的生物标志物来检测大脑，这可能会有所帮助。在阿尔茨海默病的主要症状出现之前及早发现变化有所不同。功能和进展以不同的速度进行，我们将尝试找出可能导致这种变化的因素。核心感兴趣的另一个领域是开发更好的方法来评估拉丁裔，支持通过拉丁裔核心的社会、文化和研究专业知识。最后，该核心将与 ADRC 的其他成员合作，维护和扩大研究登记处—— 准备好的志愿者。