FICSIT COLLABORATIVE ANALYSES

FICSIT 协作分析

• 批准号: 3546304
• 负责人: MARIA A FIATARONE
• 金额: $ 6.74万
• 依托单位: HEBREW REHABILITATION CENTER FOR AGED
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-16 至 1994-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3546304
• 关键词: accidental falls; balance; bioenergetics; biopsy; body composition; body physical activity; computed axial tomography; diet; exercise; frail elderly; functional ability; gait; human subject; human very old age (85+); injury prevention; muscle contraction; muscle function; muscle strength; neuromuscular function; nutrient requirement; nutrition of aging; nutrition related tag; physical fitness; restricted physical activity

Muscle weakness and mobility impairment are important risk factors for falls in the frail elderly. Marked decreases in muscle strength may be attributable to: 1) biological changes of aging, 2) acute and chronic diseases, 3) sedentary lifestyle and 4) selective or generalized nutritional inadequacies. Inactivity and undernutrition are potentially reversible with appropriate intervention. We postulate that improved muscle strength through exercise and nutrition will result in improved clinical and functional status and reduced risk of falls. The goals of this study are: 1) To characterize muscle function in the elderly with a history of recurrent falls, and 2) to perform a trial of vigorous progressive resistance training of the leg muscles and/or multi- nutrient supplementation, in order to improve muscle strength and mobility. One hundred frail institutionalized fallers aged 80-99 will be recruited from the Hebrew Rehabilitation Center for Aged (HCRA). Using a blinded randomized design, subjects will participate in one of four ten-week interventions: 1) placebo and sedentary activity group, 2) nutritional supplement and sedentary activity group, 3) placebo and strength training, or 4) nutritional supplement and strength training. Clinical and functional correlates of muscle performance will be assessed by mobility, gait and balance, falls, acute illnesses and medication use, activities of daily living, and mental status. Since muscle mass is closely related to strength, body composition will be measured by anthropometry, whole body potassium, total body water, bioelectric impedance, and CT scan. The histological and biochemical characteristics of muscle will be determined in a biopsy from m. vastus lateralis. Muscle function will be measured in knee and hip extensions as the maximum load that can voluntarily be lifted (the one repetition maximum, or 1RM). Adductor pollicis stimulation will be used to determine contractility characteristics. Habitual level of physical activity will be quantified by average daily energy expenditure, using the new, objective technique of doubly-labeled water, as well as movements/day from activity monitors. Three-day food weighing, body composition and blood nutritional profile will be used to determine relationships between nutrient intake, nutritional status, and muscle function. This study will provide important data on the feasibility and efficacy of new strategies for improving functional independence and reducing falls in this population.

肌肉无力和流动性障碍是重要的风险因素 跌倒在脆弱的老年人中。 肌肉力量的明显降低可能是 归因于：1）衰老的生物学变化，2）急性和慢性 疾病，3）久坐的生活方式和4）选择性或广义 营养不足。 不活动和营养不良可能是 通过适当的干预可逆。 我们假设有所改善 通过运动和营养通过肌肉力量会改善 临床和功能状况，降低了跌倒的风险。 这项研究的目标是：1）表征在 具有经常性跌倒史的老年人，2）进行试验 对腿部肌肉和/或多种进行剧烈的渐进性训练 补充营养，以提高肌肉力量和活动能力。 一百个脆弱的制度化的堕落者将招募80-99岁的堕落者 来自希伯来语康复中心（HCRA）。 使用盲人 随机设计，受试者将参加十周的四个星期之一 干预措施：1）安慰剂和久坐活动组，2）营养 补充和久坐活动组，3）安慰剂和力量训练， 或4）营养补充和力量训练。 临床和 肌肉性能的功能相关性将通过移动性评估， 步态与平衡，跌倒，急性疾病和药物使用，活动 日常生活和心理状况。 由于肌肉质量与 强度，身体成分将通过人体测量法测量，整个身体 钾，全身水，生物电阻抗和CT扫描。 这 将确定肌肉的组织学和生化特征 在M中的活检中。巨大的外侧。 肌肉功能将在 膝盖和髋关节延伸作为可以自愿举起的最大负载 （最大重复或1RM）。 加和粉的刺激将 用于确定收缩性特征。 习惯水平 体育活动将通过平均每日能量消耗来量化 使用新型的双重标签水的客观技术，以及 活动监视器的运动/天。 三天的食物称重，身体 组成和血液营养概况将用于确定 营养摄入，营养状况和肌肉之间的关系 功能。 这项研究将提供有关可行性和 新策略改善功能独立性和 减少该人群的跌倒。