NINDS Human Cell and Data Repository (U24)

NINDS 人类细胞和数据存储库 (U24)

• 批准号: 10402150
• 负责人: JENNIFER C MOORE
• 金额: $ 30.52万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10402150
• 关键词: Affect; Cell Line; Cells; Communities; Data; Development; Disease; Disease Progression; Disease model; Drug Screening; Frontotemporal Dementia; Generations; Genetic; Genomics; Housing; Human; Human Development; Information Dissemination; Lewy Body Dementia; National Institute of Neurological Disorders and Stroke; Research Personnel; Source; Technology; Testing; Toxicology; cell repository; combat; data repository; drug discovery; genome sequencing; human data; human disease; human model; induced pluripotent stem cell; mRNA sequencing; nervous system disorder; repository; transcriptomics; treatment strategy; web site; whole genome

Abstract The NINDS Cell and Human Data Repository (NHCDR), housed at Infinity BiologiX distributes source cells and iPSC to academic and for-profit researchers worldwide. The focus of this repository is to provide the global scientific community with the highest quality cell lines for models of human development and disease progression and for drug screening and toxicology. The NHCDR website serves as the portal for both requesting cells lines and for housing data related to them. This application is to support whole genome sequencing and mRNA-seq of iPSC generated from subjects with Frontotemporal Dementia or Lewy Body Dementia and the dissemination of the resulting data through the NHCDR website. This data will also be used to better understand genomic changes that can occur during the generation of iPSC and the transcriptomic differences between independent iPSC isolates from a single reprogramming.

抽象的 位于 Infinity BiologiX 的 NINDS 细胞和人类数据存储库 (NHCDR) 负责分发源细胞 和 iPSC 面向全球学术和营利性研究人员。该存储库的重点是提供 全球科学界拥有用于人类发展模型的最高质量细胞系 疾病进展以及药物筛选和毒理学。 NHCDR 网站作为门户网站 两者都请求细胞系并获取与其相关的数据。这个应用程序是为了支持整个 额颞叶痴呆受试者产生的 iPSC 的基因组测序和 mRNA-seq 或 路易体痴呆症以及通过 NHCDR 网站传播所得数据。这个数据 还将用于更好地了解 iPSC 生成过程中可能发生的基因组变化 以及单次重编程的独立 iPSC 分离株之间的转录组差异。