Mechanisms that underlie cross-modal sensory plasticity - Diversity Research Supplements to Promote Diversity in Health-Related Research

跨模式感觉可塑性的机制 - 促进健康相关研究多样性的多样性研究补充

• 批准号: 10404187
• 负责人: BING YE
• 金额: $ 7.68万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10404187
• 关键词: Affect; Animals; Behavioral Model; Complement; Cues; Development; Drosophila genus; Ensure; FMRP; Financial compensation; Future; Genes; Goals; Grant; Habitats; Health; Individual; Individual Differences; Knowledge; Larva; Learning; Mission; Modality; Molecular; Neurodevelopmental Disorder; Neurons; Nociceptors; Oral; Parents; Perception; Positioning Attribute; Public Health; Research; Research Activity; Sensory; Sensory Deprivation; Synaptic Transmission; System; Training; Training Support; United States National Institutes of Health; Writing; behavioral plasticity; career; experience; improved; mature animal; molecular modeling; multimodality; multisensory; nervous system disorder; parent grant; relating to nervous system; sensory stimulus; sensory system; skills; somatosensory; synaptic inhibition

PROJECT SUMMARY Sensory experiences during development profoundly influence sensory processing in mature animals. Since most of an animal’s sensory experiences are multimodal, the activity of one sensory modality often causes long-term changes in another modality. Such cross-modal plasticity not only leads to compensation for sensory functions in the case of sensory deprivation, but also allows normal individuals to respond properly to sensory stimuli in their unique habitats or situations and contributes to individual’s differences in the perception of multisensory cues. Despite the importance of cross-modal plasticity, the underlying circuit and molecular mechanisms are poorly understood. The objective of the parent grant R01NS104299 is to identify the mechanisms that underlie cross-modal plasticity in the developing somatosensory system of Drosophila larvae, and provide circuit and molecular models for guiding future studies in other species. The central hypothesis is that gentle mechanosensory inputs during development strengthen serotonergic inhibition of the synaptic transmission from nociceptors to multisensory second-order neurons (MSONs), which is achieved through specific genes in the MSONs. The requested Research Supplement to Promote Diversity in Health-Related Research will support the training of an outstanding postbaccalaureate. The research proposed will supplement the originally proposed studies to ensure the successful attainment of its aims. Two studies are proposed to supplement the original Aim 2: (1) determine whether FMRP is required for cross-model behavioral plasticity; and (2) determine whether cross-modal plasticity affects neural ensemble activities. These research activities will expand the research experiences of the supplementee. Moreover, they will provide opportunities for her to learn scientific writing, oral presentation skills, and networking. These training will position her strongly for a health-related research career.

项目概要 发育过程中的感官体验深刻影响成熟动物的感官处理。 大多数动物的感官体验是多模态的，一种感官模态的活动通常会导致 另一种模式的长期变化不仅会导致补偿。 感觉功能在感觉剥夺的情况下，也能让正常人做出适当的反应 其独特的栖息地或情况下的感官刺激，并有助于个体的差异 尽管跨模态可塑性很重要，但基础电路和 分子机制尚不清楚。母基金 R01NS104299 的目的是确定。 果蝇体感系统发育中跨模式可塑性的机制 幼虫，并提供电路和分子模型来指导其他物种的未来研究。 假设是，发育过程中温和的机械感觉输入会加强血清素能抑制 从伤害感受器到多感觉二阶神经元（MSON）的突触传递， 通过 MSON 中的特定基因实现所要求的促进多样性的研究补充。 健康相关研究博士学位将支持杰出学士后的培训。 拟议的研究将补充最初提出的研究，以确保成功实现其目标。 提出两项研究来补充最初的目标 2：（1）确定 FMRP 是否需要 跨模型行为可塑性；（2）确定跨模型可塑性是否影响神经整体 这些研究活动将扩大补充者的研究经验。 他们将为她提供学习科学写作、口头表达技巧和网络的机会。 这些培训将使她为健康相关的研究职业做好准备。