Structure, function, and pharmacology of neuronal membrane transport proteins

神经元膜转运蛋白的结构、功能和药理学

• 批准号: 10403716
• 负责人: Seok-Yong Lee
• 金额: $ 2.82万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10403716
• 关键词: Applications Grants; Cell membrane; Cell physiology; Cells; Development; Disease; Electrophysiology (science); Epilepsy; Event; Future; G Protein-Coupled Receptor Signaling; Goals; Human; Hyperactivity; Intervention; Maintenance; Mediating; Membrane; Membrane Potentials; Membrane Transport Proteins; Molecular; Mutation; Neurobiology; Neurons; Nociception; Pain; Parents; Patients; Pharmacology; Pharmacology Study; Physiological; Play; Process; Property; Protein Engineering; Proteins; Pruritus; Regulation; Research; Role; Sensory Physiology; Signal Transduction; Signaling Molecule; Structure; System; TYRP1 gene; Therapeutic; Translating; Transmembrane Transport; Transport Process; Transportation; Valverde; career; chronic itch; chronic pain; design; epileptic encephalopathies; interdisciplinary approach; interest; mu opioid receptors; nervous system disorder; pain reduction; pain sensation; parent grant; structural biology; therapeutic development; tool; transmission process

Project Summary Membrane transport proteins are responsible for the passage of key molecules and the transfer of information across cell membranes, which are events central to many important neurobiological processes. They are designed to selectively recognize a variety of substrates of differing sizes and physicochemical properties for cellular transport. My overarching research goals are to understand the design principles of neuronal membrane transport proteins that are involved in pain and/or itch sensation and transmission, to develop pharmacological tools to modulate their function, and to apply the information gained from this research to exploit their therapeutic potential using a multidisciplinary approach including structural biology, electrophysiology, and pharmacology.

项目概要 膜转运蛋白负责关键分子的通过和转运 跨细胞膜的信息，这是许多重要神经生物学的核心事件 流程。它们旨在选择性地识别各种不同尺寸的基材， 细胞运输的物理化学特性。我的总体研究目标是了解 涉及疼痛和/或瘙痒的神经元膜转运蛋白的设计原理 感觉和传递，开发药理学工具来调节其功能，并应用 从这项研究中获得的信息，利用多学科的方法来开发其治疗潜力 方法包括结构生物学、电生理学和药理学。