Home Sleep Apnea Testing and Neurocognitive Testing for Obstructive Sleep Apnea in Young Adults with Down Syndrome

主页患有唐氏综合症的年轻人的阻塞性睡眠呼吸暂停的睡眠呼吸暂停测试和神经认知测试

基本信息

批准号：
10404772
负责人：
ANDREA Bridget KELLY
金额：
$ 24.74万
依托单位：
CHILDREN'S HOSP OF PHILADELPHIA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2023-08-31
项目状态：
已结题

项目摘要

ABSTRACT Obstructive sleep apnea syndrome (OSAS) is highly prevalent in people with Down syndrome (DS), but few studies have investigated its emergence, evolution, and contribution to patient-reported outcomes and co- morbidities, including neurocognitive dysfunction and cardiometabolic and cardiovascular risk. These knowledge gaps have stymied DS health care recommendation development as highlighted by the American Academy of Pediatrics guidelines that all children with DS undergo a sleep study by 4 years of age but that do not address ongoing surveillance. Moreover, major challenges to both clinical care and research related to OSAS in DS is the requirement of an in-laboratory overnight polysomnography (PSG) partly due to the scarcity of dedicated sleep laboratories with expertise in the care of individuals with intellectual disabilities. This supplement will leverage an ongoing study of feasibility, acceptability, and performance of home sleep apnea testing (HSAT) vs PSG in 35 youth aged 10-20 years with DS and expand enrollment by n=15 additional individuals aged 16-30y to 1) secure training in neurocognitive testing in young adults with DS through a new collaboration, 2) estimate recruitment yields when fasting blood work and neurocognitive testing are included in the study, and 3) obtain preliminary estimates examining the relationships of OSAS with a) neurocognitive function and b) cardiometabolic risk markers and OSAS treatment uptake in individuals with OSAS identified in the context of the parent award. This work will inform an OSAS intervention study aimed at adult comorbidities (DS-related Alzheimer disease and dementia, cardiovascular health) and a longitudinal history study of OSAS in adolescents and young adults with DS. Importantly, data derived from this supplement will ultimately address knowledge gaps surrounding OSAS screening, patient-focused and clinical relevance of OSAS treatment, and potentially modifiable risk factors for dementia.

抽象的阻塞性睡眠呼吸暂停综合征 (OSAS) 在唐氏综合症 (DS) 患者中非常普遍，但很少研究调查了它的出现、演变以及对患者报告结果的贡献以及共同发病率，包括神经认知功能障碍以及心脏代谢和心血管风险。这些知识正如美国科学院所强调的那样，差距阻碍了 DS 医疗保健建议的制定儿科指南要求所有患有 DS 的儿童在 4 岁时接受睡眠研究，但这并没有解决持续监视。此外，与 DS 中 OSAS 相关的临床护理和研究面临的主要挑战是实验室内过夜多导睡眠图 (PSG) 的要求部分是由于缺乏专用的睡眠实验室拥有护理智障人士的专业知识。本补充将利用正在进行的关于家庭睡眠呼吸暂停测试 (HSAT) 与家庭睡眠呼吸暂停测试 (HSAT) 的可行性、可接受性和性能的研究对 35 名 10-20 岁患有 DS 的青少年进行 PSG 治疗，并扩大入学人数 n=15 名 16-30 岁的其他人 1) 通过新的合作确保患有 DS 的年轻人接受神经认知测试培训，2) 估计研究中包括空腹血液检查和神经认知测试时的招募率，并且 3) 获得初步估计检查 OSAS 与 a) 神经认知功能和 b) 的关系心脏代谢风险标志物和 OSAS 患者接受 OSAS 治疗的情况家长奖。这项工作将为针对成人合并症（DS 相关疾病）的 OSAS 干预研究提供信息阿尔茨海默病和痴呆、心血管健康）以及青少年 OSAS 的纵向历史研究以及患有 DS 的年轻人。重要的是，从本补充中获得的数据最终将解决知识问题围绕 OSAS 筛查、OSAS 治疗以患者为中心和临床相关性的差距，以及潜在的痴呆症的可改变危险因素。