NEURAL PATHWAYS UNDERLYING EMOTIONAL CONDITIONING

情绪调节的神经通路

• 批准号: 2244690
• 负责人: JOSEPH E LEDOUX
• 金额: $ 28.42万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2244690
• 关键词: action potentials; amygdala; auditory cortex; auditory pathways; auditory stimulus; brain mapping; conditioning; electrophysiology; electrostimulus; emotions; experimental brain lesion; fear; histochemistry /cytochemistry; laboratory rat; learning; lectin; medial geniculate body; neural information processing; neural plasticity; neuroanatomy; nontherapeutic iontophoresis; peroxidases; sensory mechanism; stereotaxic techniques; thalamus; action potentials; amygdala; auditory cortex; auditory pathways; auditory stimulus; brain mapping; conditioning; electrophysiology; electrostimulus; emotions; experimental brain lesion; fear; histochemistry /cytochemistry; laboratory rat; learning; lectin; medial geniculate body; neural information processing; neural plasticity; neuroanatomy; nontherapeutic iontophoresis; peroxidases; sensory mechanism; stereotaxic techniques; thalamus

The of the proposed research is to understand the processing of emotion by the brain. The experiments are specifically concerned with the mechanisms by which insignificant events in the environment acquire salience as emotional signals. Previously, we demonstrated that a specific subcortical pathway, the geniculo- amygdala projection system, mediates the classical conditioning of fear responses to acoustic stimuli. In the present series of experiments we seek to extend these observations. Three projects are planned. Project 1 is concerned with the local mechanisms in the medial geniculate body and amygdala which mediate fear conditioning. The aims are to: (a) identify the precise anatomical location and topographic organization of the cells of origin and termination of the geniculo-amygdala projection; (b) determine whether lesions of the cells of origin and termination of the pathway disrupt fear conditioning; (c) characterize the sensory processing functions of the geniculo-amygdala projection using electrophysiological goal of Project 2 is to determine processing limits of the geniculo-amygdala projection by identifying aversive classical conditioning tasks which require the integrity of the auditory cortex. In these experiments animals with lesions of the auditory cortex will be conditioned using stimuli which must be discriminated on the basis of various sensory/perceptual properties. Project 3 then examines whether connections between the auditory cortex and the amygdala mediate emotional conditioning in training situations which require the auditory cortex. The aims are to: (a) localize the auditory receptive cortex using physiological mapping techniques; (b) identify pathways connecting acoustically responsive areas of the cortex with the amygdala; and (c) determine whether interruption of these pathways disrupts the conditioning of emotional responses which are dependent upon the auditory cortex. Together, the various experiments will individually and collectively to emotional information processing.

拟议的研究是了解 大脑的情感。 实验特别关心 具有微不足道的事件中的机制 环境将显着性作为情感信号。 以前，我们 证明了特定的皮层途径，Geniculo- 杏仁核投影系统，介导 害怕对声学刺激的反应。 在目前的系列 我们寻求扩展这些观察结果的实验​​。 三个项目 计划。 项目1关注的是当地机制 内侧的晶状体和杏仁核，介导恐惧 调理。 目的是：（a）确定确切的 细胞的解剖位置和地形组织 Geniculo-Amygdala投影的起源和终止； （b） 确定原点细胞和终止细胞的病变是否 路径破坏恐惧调节； （c）表征 Geniculo-Amygdala投影的感觉处理功能 使用项目2的电生理目标是确定 geniculo-amygdala投影的处理极限 识别需要的厌恶经典调节任务 听觉皮层的完整性。 在这些实验中 带有听觉皮层病变的病变将使用 刺激必须根据各种 感觉/感知属性。 项目3然后检查是否 听觉皮层与杏仁核中间的连接 在训练情况下的情绪调节，需要 听觉皮层。 目的是：（a）本地化听觉 使用生理映射技术接受皮层； （b） 识别连接声音响应区域的途径 杏仁核的皮质； （c）确定是否中断 这些途径破坏了情绪反应的调理 取决于听觉皮层。 在一起， 各种实验将单独和集体致力于情感 信息处理。