University of New Mexico (UNM) Center for Brain Recovery and Repair

新墨西哥大学 (UNM) 脑恢复和修复中心

基本信息

批准号：
10400522
负责人：
Claude W Shuttleworth
金额：
$ 21.69万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-15 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10400522
关键词：
Acute Brain Injuries Address Adoption Animal Experimentation Basic Science Behavior Brain Brain Injuries Caring Cell Nucleus Centers of Research Excellence Clinical Clinical Investigator Cognitive Collaborations Communities Complement Core Facility Development Electrophysiology (science)Ensure Evolution Exposure to Extramural Activities Faculty Family Fertilization Funding Goals Grant Home Hospitals Image Individual Inpatients Institution Intensive Care Units Interdisciplinary Study Intervention Laboratories Leadership Life Mentors Methods Mexican Motor Neurons New Mexico Outcome Outpatients Patients Phase Physiology Positioning Attribute Quality of life Recovery Recovery of Function Research Research Personnel Resource Sharing Resources Rodent Rodent Model Services Severities Stroke Structure Students Survivors Time Training Trauma Traumatic Brain Injury Traumatic injury Universities Work base behavioral health brain health brain research career clinical application cognitive control cognitive testing cohort community living cost data streams disability effective intervention effective therapy equipment acquisition faculty mentor improved injured innovation interdisciplinary collaboration mortality multimodal data neurophysiology novel personalized approach pre-clinical prevent programs repaired senior faculty societal costs success symposium tenure track

项目摘要

SUMMARY Survivors of brain injuries such as stroke and trauma often endure life-long disabilities, which span a spectrum of deficits and are associated with enormous individual and societal costs. There is an urgent need to develop effective interventions that can improve cognitive and motor outcomes, especially individualized approaches that target specific disruptions of brain physiology or circuits. The Center for Brain Recovery and Repair was established in Phase I as an interdisciplinary community of investigators to address these issues. A cohort of junior faculty successfully launched new independent research programs and have remained centrally active within the Center. Together with core leadership and other established investigators from diverse departments and programs across campus, we have established a highly interactive nucleus, working closely together in a physical home in Domenici Hall. Phase II activities build on this progress, by adding additional layers of mentored faculty, projects and resources required to ensure a self-sustaining, high impact Center. The Center will maintain its successful focus on moving laboratory discoveries about brain injury mechanisms into clinical application, and will therefore continue to emphasize a structure that promotes extensive mentoring and interaction between preclinical and clinical investigators. The physical home in Domenici Hall will be enhanced, to strengthen state-of-the-art facilities for both rodent studies and clinical interventions and assessment. Recordings from brain-injured patients in the neuro intensive care unit will also be studied in our Domenici Hall core facilities in Phase II, to address novel, actionable mechanisms earlier in the progression of brain injury. Innovative combinations of electrophysiology, imaging and cognitive assessment will be led by both the clinical and preclinical cores, with extensive cross-fertilization of ideas and approaches. An exciting set of projects using these cores will be led by junior faculty from different departments, addressing different severities and consequences of traumatic brain injury. An expanded pilot program, together with new partnerships and tenure-track hires will further increase the critical mass of investigators in the Center, supporting fiscal sustainability and increasing competitiveness for center-level support with additional extramural grants. The Center will leverage existing facilities and trainings at UNM, and expand valuable collaborations with regional IDeA programs for pipeline development and resource sharing. The significantly enhanced research capabilities will thus be available for a larger constituency of brain and behavioral health investigators in New Mexico, and investigators in other IDeA states. Such outcomes are expected to have an important positive impact, as they will greatly accelerate the discovery and adoption of interventions that are urgently needed for large numbers of individuals in IDeA communities living with the devastating consequences of brain injury.

概括中风和创伤等脑损伤的幸存者往往会遭受终生残疾，这种残疾会持续很长时间一系列赤字，并与巨大的个人和社会成本相关。有紧急情况需要制定有效的干预措施来改善认知和运动结果，特别是针对大脑生理或回路的特定破坏的个性化方法。该中心大脑恢复和修复在第一阶段成立，作为一个跨学科的研究人员社区解决这些问题。一批初级教师成功启动了新的独立研究项目并一直在中心内保持活跃。与核心领导层和其他既定成员一起来自校园不同部门和项目的研究人员，我们建立了一个高度互动核心，在多梅尼奇大厅的实体住宅中紧密合作。第二阶段活动搭建在这一进展的基础上，通过增加额外的指导教师、项目和资源来确保一个自我维持、高影响力的中心。该中心将继续成功地将重点放在移动实验室上关于脑损伤机制的发现进入临床应用，因此将继续强调促进临床前和临床研究人员之间广泛指导和互动的结构。多梅尼奇大厅的实体住宅将得到改善，为啮齿动物提供最先进的设施研究以及临床干预和评估。脑损伤患者的神经记录重症监护病房也将在第二阶段的 Domenici Hall 核心设施中进行研究，以解决新的、脑损伤进展早期的可行机制。创新组合电生理学、成像和认知评估将由临床和临床前核心领导，思想和方法的广泛交叉。一系列令人兴奋的使用这些核心的项目将由来自不同部门的初级教师领导，解决不同的严重性和后果脑外伤。扩大试点计划，以及新的合作伙伴关系和终身职位聘用将进一步增加该中心调查人员的数量，支持财政可持续性和通过额外的校外赠款提高中心级支持的竞争力。该中心将利用 UNM 的现有设施和培训，并扩大与地区 IDeA 的宝贵合作管道开发和资源共享计划。科研能力显着增强因此，将可供新墨西哥州更多的大脑和行为健康研究人员使用，并且其他 IDeA 州的调查员。这些成果预计将产生重要的积极影响，因为它们将大大加速大量人员迫切需要的干预措施的发现和采用 IDeA 社区中的个人遭受脑损伤的毁灭性后果。