Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed)

促进健康相关研究多样性的研究补充（管理补充 - 不允许进行临床试验）

• 批准号: 10400398
• 负责人: Stephania A Cormier
• 金额: $ 2.92万
• 依托单位: LOUISIANA STATE UNIV A&M COL BATON ROUGE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-22 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10400398
• 关键词: Address; Biological; Biomedical Research; Chemicals; Clinical Trials; Data; Exposure to; Free Radical Formation; Free Radicals; Goals; Grant; Health; Human; Laboratories; Laccase; Lung; Mentors; Methodology; Methods; Myron; National Institute of Environmental Health Sciences; Nature; Oxidation-Reduction; Prevention; Reproducibility; Research; Research Project Grants; STEM field; Soil; Superfund; System; Training; Training Activity; Underrepresented Minority; Work; Writing; advanced analytics; analytical method; base; cardiovascular health; career development; data sharing; lard; recruit; remediation; response; responsible research conduct; skills

Project Summary/Abstract The evidence is strong that underrepresentation of minorities in the STEM fields is a critical issue that needs to be addressed. One of the objectives of this proposal is to recruit, support, and mentor a trainee, Mr. Myron Lard, from an underrepresented background, for Project 5 of LSU Superfund Research Center – Environmentally Persistent Free Radicals (NIEHS grant #2-P42ES013648-09) through a research supplement to promote diversity in health-related research (following PA-21-071). The aim of the research at the LSU Center is to understand how environmentally persistent free radicals (EPFRs) are formed and how they impact pulmonary and cardiovascular health, as well as to develop prevention, remediation, and human health protective strategies based on fundamental physical, chemical, and biological understanding, with Project 5 focusing on the fundamental physical and chemical understanding. The project can be viewed as two components. The first component is the scientific research in which laboratory-generated EPFR systems, mimicking EPFR-containing soils, will be studied to determine if 1) EPFR formation by multiple redox centers is additive and 2) biological inputs, such as laccase, induce further EPFR formation beyond that seen in abiotic systems. The laboratory-generated EPFRs will then be studied by advanced analytical methods to gain an atomic-level understanding of EPFR formation and the nature of the formed EPFRs. Subsequently, and in conjunction with Projects 1 and 2, biological exposure to the laboratory-generated EPFRs will be performed, with the main goal of using atomic-level information to predict the nature and magnitude of the biological responses to these EPFRs. In addition to the experimental training, in the second component of this project, Mr. Lard will be mentored in scientific research presentation skills, new methodologies, methods for enhancing rigor and the reproducibility of data as well as data sharing, the Responsible Conduct of Research, grant writing, and career development. When combined, these training activities will enhance Myron's research capabilities, particularly in the field of biomedical research.

项目概要/摘要 强有力的证据表明，少数族裔在 STEM 领域的代表性不足是一个问题 该提案的目标之一是需要解决的关键问题。 从代表性不足的地区招募、支持和指导一名实习生 Myron Lard 先生 背景，路易斯安那州立大学超级基金研究中心项目 5 – 环境 通过研究发现持久自由基（NIEHS 拨款 #2-P42ES013648-09） 促进健康相关研究多样性的补充（遵循 PA-21-071）。 路易斯安那州立大学中心的研究目的是了解环境持久性如何 自由基 (EPFR) 的形成及其如何影响肺部和心血管 健康，以及制定预防、补救和人类健康保护措施 基于基本物理、化学和生物学理解的策略， 项目 5 侧重于基本的物理和化学理解。 可以被视为两个组成部分，第一个组成部分是科学研究。 将研究实验室生成的 EPFR 系统，模仿含有 EPFR 的土壤，以 确定 1) 多个氧化还原中心形成的 EPFR 是否是累加性的，以及 2) 生物性的 输入，如漆酶，诱导进一步的 EPFR 形成，超出了非生物中所见的范围 然后，实验室生成的 EPFR 将通过先进的分析进行研究。 获得对 EPFR 形成及其性质的原子级理解的方法 随后，与项目 1 和 2 一起形成了 EPFR。 将暴露于实验室生成的 EPFR，主要目标是 使用原子级信息来预测生物的性质和大小 对这些 EPFR 的反应 除了实验训练之外，在第二个中。 作为该项目的一部分，Lard 先生将在科学研究演示方面接受指导 技能、新方法、增强数据严谨性和可重复性的方法 以及数据共享、负责任的研究行为、资助写作和职业生涯 这些培训活动结合起来将增强迈伦的研究。 能力，特别是在生物医学研究领域。