LSU Superfund Research Center - Environmentally Persistent Free Radicals

路易斯安那州立大学超级基金研究中心 - 环境持久性自由基

基本信息

批准号：
10770302
负责人：
Stephania A Cormier
金额：
$ 2.08万
依托单位：
LOUISIANA STATE UNIV A&M COL BATON ROUGE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-22 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10770302
关键词：
Address Adult Advisory Committees Advocacy Affect Age Archives Area Asthma Atmosphere Attenuated Biological Birth Cardiac Cardiopulmonary Cardiovascular Diseases Cardiovascular system Chemicals Chemistry Child Childhood Childhood Asthma Communication Communities Copper Data Data Analyses Degradation Pathway Dioxins Education Engineering Ensure Environment Environmental Health Evaluation Exclusion Exposure to F2-Isoprostanes Factor Analysis Failure Fostering Free Radical Formation Free Radicals Free Will Functional disorder Funding Goals Government Agencies Hazardous Substances Hazardous Waste Health Health Policy House Dust Human Hydroxyl Radical Industry Inhalation Exposure Inhalation Toxicology Link Location Lung Metabolic Metals Methods Monitor Organic Chemicals Organism Outcome Oxidative Stress Oxidative Stress Induction Particulate Matter Persons Physics Pneumonia Population Prevention Process Protocols documentation Public Health Reaction Reagent Regulation Research Research Personnel Research Project Grants Resources Risk Risk Assessment Role Route Sampling Services Silicon Dioxide Site Superfund Surface System Technology Toxic effect Training Transition Elements Wheezing Work biomarker identification cohort community engagement data management detection method environmental particulate experience exposed human population ground water improved in vivo interdisciplinary approach iron oxide metal oxide mouse model oxidative damage particle pollutant prevent programs remediation respiratory respiratory health sensor success superfund site technique development treatment site wasting web portal

项目摘要

Project Summary/Abstract: Overall Nearly 53 million people (17% of the US population; 18% of children <5 yrs) live within 3 miles of a Superfund remediation site. Superfund sites contain a wide variety of pollutants, including organic chemicals, metals, carbo- naceous material and silica. Although each of these components is capable of damage to organisms, their poten- tial to combine into unique hazardous agents has been understudied. Interestingly, when these agents are pre- sent together, particularly during thermal remediation, they combine to form particulate matter (PM) with chemi- sorbed free radicals that persist in the environment and yet are biologically active. We call these pollutant-particle systems environmentally persistent free radicals (EPFRs). EPFRs are produced during thermal treatment of haz- ardous wastes and nearly 30% of all Superfund sites (excluding groundwater) are remediated by thermal treat- ment. EPFR concentrations near Superfund sites range from 1x1018-4x1019 EPFRs/g (spins/g) of PM. This sug- gests a vast number of US residents are exposed to PM containing EPFRs. LSU Superfund Research Center researchers have shown that these EPFRs 1) induce cardiac and pulmonary dysfunction in the exposed host, 2) are associated with current wheeze in children if present in household dust, and 3) are intermediates in the for- mation of new pollutants such as dioxins. Our Center now seeks to understand how EPFRs induce pulmo- nary/cardiovascular dysfunction and how to attenuate EPFR formation, facilitate EPFR decay, and limit exposure to EPFRs, with the ultimate goal of improving human health and the environment. We will determine how EPFRs are formed, stabilized, and decay and how they catalytically cycle to produce hydroxyl radicals. This will be done using a suite of advanced surface and chemical analyses. Since the airway is a major site of entry of environ- mental PM, we will demonstrate a link between EPFR exposure and poor respiratory health in children using es- tablished community-based birth cohorts. We will explore mechanisms of EPFR-induced asthma and cardiovas- cular disease using mouse models exposed by inhalation. Support cores (Administration, Data Management & Analysis, Community Engagement, Research Experience and Training Coordination, Materials, and Inhalation Toxicology) will provide essential, centralized reagents/services and technological resources allowing for precision of data and economy of effort, and foster interdisciplinary activities. To ensure success, experts in these respective fields were brought together as an External Advisory Committee to advise this Center. The chemistry and physics of EPFRs, let alone their health impacts, are poorly understood, and an interdisciplinary approach is required to address the critical research areas.

项目摘要/摘要：总体近 5300 万人（美国人口的 17%；5 岁以下儿童的 18%）居住在超级基金 3 英里范围内整治现场。超级基金场地含有多种污染物，包括有机化学品、金属、碳水质材料和二氧化硅。尽管这些成分中的每一种都能够损害生物体，但它们的潜力组合成独特危险剂的方法尚未得到充分研究。有趣的是，当这些代理被预先一起发送，特别是在热修复过程中，它们与化学物质结合形成颗粒物（PM）吸附的自由基持续存在于环境中，但具有生物活性。我们称这些污染物为颗粒物系统环境持久性自由基（EPFR）。 EPFR 是在有害物质的热处理过程中产生的危险废物和近 30% 的超级基金场地（不包括地下水）均通过热处理进行修复 ment。超级基金站点附近的 EPFR 浓度范围为 1x1018-4x1019 EPFR/g（旋转/g）PM。这个建议—— 导致大量美国居民接触含有 EPFR 的 PM。路易斯安那州立大学超级基金研究中心研究人员表明，这些 EPFR 1) 会导致暴露宿主的心脏和肺功能障碍，2) 如果存在于家庭灰尘中，则与儿童当前的喘息有关，并且 3) 是以下物质的中间体：产生二恶英等新污染物。我们的中心现在试图了解 EPFRs 如何诱导肺- 神经/心血管功能障碍以及如何减弱 EPFR 形成、促进 EPFR 衰减和限制暴露 EPFR，最终目标是改善人类健康和环境。我们将确定 EPFR 如何形成、稳定和衰变以及它们如何催化循环产生羟基自由基。这将完成使用一套先进的表面和化学分析。由于气道是环境进入的主要场所心理 PM，我们将使用 es- 来证明 EPFR 暴露与儿童呼吸系统健康状况不佳之间的联系建立了基于社区的出生队列。我们将探讨 EPFR 诱发哮喘和心血管的机制使用通过吸入暴露的小鼠模型来观察眼部疾病。支持核心（管理、数据管理和分析、社区参与、研究经验和培训协调、材料和吸入毒理学）将提供必要的、集中的试剂/服务和技术资源，以便数据的准确性和工作的经济性，并促进跨学科活动。为了确保成功，这些领域的专家各个领域聚集在一起组成一个外部咨询委员会，为该中心提供建议。化学人们对 EPFR 的概念和物理学知之甚少，更不用说它们对健康的影响了，需要跨学科的方法需要解决关键研究领域。