MUSC Digestive Disease Research Core Center

MUSC消化疾病研究核心中心

基本信息

批准号：
10395941
负责人：
DON C. ROCKEY
金额：
$ 108.76万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10395941
关键词：
Area Award Basic Science Biology Biomedical Research Cell model Cells Clinical Clinical Research Clinical Sciences Collaborations Colon Complement Core Facility Curiosities Development Digestive System Disorders Disease Ensure Esophagitis Esophagus Evaluation Fibrosis Fostering Foundations Functional disorder Funding Gastrointestinal Diseases Gastrointestinal tract structure Goals Health Healthcare Hepatocyte Image Imaging Techniques Inflammation Inflammatory Bowel Diseases Injury Investigation Investments Lead Leadership Liver Liver diseases Malignant Neoplasms Medical Mentorship Mission Modeling National Institute of Diabetes and Digestive and Kidney Diseases Organ Pancreas Participant Pathogenesis Patient-Focused Outcomes Patients Performance Process Proteomics Research Research Infrastructure Research Personnel Resources Scholarship Science Scientific Inquiry Small Intestines South Carolina Stomach Structure Tissues Translating Translational Research Universities Vision Work base career development cell injury chronic pancreatitis design driving force flexibility gastrointestinal human disease human model imaging capabilities improved innovation instrumentation liver injury mass spectrometric imaging member novel novel therapeutics organ injury programs research study success tissue culture

项目摘要

Center Overview - Abstract The vision for the Medical University of South Carolina (MUSC) Digestive Disease Research Core Center (DDRCC) is to create a culture of curiosity, scholarship, and investigation around our central theme. Our theme is informed by the pathogenesis of disease in the gastrointestinal tract, from cellular injury, inflammation, fibrosis, and ultimately end organ dysfunction and disease. Our specific emphasis on human disease is part of our rationale for the extension of the continuum of our theme - from injury to disease. Further, we expect the work by Center members to lead to new treatments for patients with gastrointestinal disease. Our specific aims are integrated with the specific goal to serve our Research Base/Full Members and our mission; specific aims are as follows: (1) First, we will foster collaboration among digestive and liver disease researchers. We will leverage collaborations among MUSC investigators to further augment our research capacity while ensuring the success of a critical mass of outstanding researchers in digestive and liver diseases. This will be supported through multiple synergistic efforts as described in the Administrative Core including DDRCC leadership and Enrichment and Pilot and Feasibility Programs. (2) We will develop sustainable scientific core resources that will specifically support digestive and liver disease studies while leveraging institutional investments. The DDRCC scientific cores include: a) Analytical Cell Models Core, which will deliver high quality, pure primary liver cells and produce state-of-the-art tissue culture models; b) Advanced Imaging Core with advanced cell- and tissue-based imaging techniques and instrumentation; and c) Proteomics Core with innovative mass spectrometry imaging capabilities. These cores are complemented by a committed Clinical Component which provides support for the design, implementation and analysis of research studies to improve clinical outcomes for patients with digestive diseases. Finally, we will (3) Promote the long- term success and sustainability of the DDRCC through dedicated mentorship of New Investigators, a rigorous Center evaluation and process improvement strategy, mission alignment with other centers at MUSC, and specific long-term institutional commitments to the Center. The MUSC DDRCC is made up of 29 Full Members focused specifically on our theme, and who constitute our Research Base of $10.8M. We also have 31 Associate Members who are active participants in the Center. The DDRCC has enormous potential to answer important questions, open new areas for further inquiry, and result in potential new therapeutic discoveries that will be translated to new treatments for patients with digestive and liver disease.

中心概况 - 摘要南卡罗来纳医科大学 (MUSC) 消化疾病研究核心中心的愿景（DDRCC）的目标是围绕我们的中心主题创造一种好奇心、学术和调查的文化。我们的主题了解胃肠道疾病的发病机制，包括细胞损伤、炎症、纤维化、最终结束器官功能障碍和疾病。我们对人类疾病的特别重视是我们的一部分我们的主题连续体延伸的基本原理——从伤害到疾病。进一步，我们期待工作中心成员致力于为胃肠道疾病患者提供新的治疗方法。我们的具体目标与服务我们的研究基地/正式会员和我们的使命的具体目标相结合；具体目标如下：（一）一是加强消化病与肝病领域的合作研究人员。我们将利用 MUSC 研究人员之间的合作来进一步扩大我们的研究能力，同时确保消化和肝脏疾病领域的一批杰出研究人员取得成功。这将通过行政核心中所述的多项协同努力得到支持，包括 DDRCC 领导力以及丰富、试点和可行性计划。（二）可持续发展科学核心资源将专门支持消化和肝脏疾病研究，同时利用机构投资。 DDRCC 科学核心包括：a) 分析细胞模型核心，这将提供高质量、纯的原代肝细胞并产生最先进的组织培养模型； b) 先进的成像核心，具有先进的细胞和组织成像技术和仪器；和c) 蛋白质组学核心具有创新的质谱成像功能。这些核心由一个补充致力于临床组件，为研究的设计、实施和分析提供支持研究旨在改善消化系统疾病患者的临床结果。最后，我们将（3）促进长期通过新研究人员的专门指导、严格的指导，DDRCC 的长期成功和可持续性中心评估和流程改进策略、与 MUSC 其他中心的任务一致性，以及对中心的具体长期机构承诺。 MUSC DDRCC 由 29 名专门专注于我们主题的正式成员组成，他们构成了我们的研究基地 1080 万美元。我们还有 31 名准会员，他们是该中心的积极参与者。这 DDRCC 具有巨大的潜力来回答重要问题，为进一步探究开辟新领域，并产生潜在的新治疗发现将转化为消化系统疾病患者的新疗法肝脏疾病。