Administrative Core

行政核心

• 批准号: 10392933
• 负责人: Robert E. Lewis
• 金额: $ 116.89万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-16 至 2023-07-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10392933
• 关键词: Advisory Committees; Biology; Biotechnology; Clinical; Communication; Complex; Data Analyses; Detection; Development; Development Plans; Disease; Drug Industry; Effectiveness; Ensure; Environment; Etiology; Experimental Designs; Faculty; Fostering; Funding; Generations; Goals; Grant; Health; Human; Infrastructure; Investments; Laboratories; Lead; Leadership; Mentors; Mission; Molecular; Molecular Target; Nebraska; Outcome; Performance; Pilot Projects; Pre-Clinical Model; Procedures; Program Research Project Grants; Reporting; Research; Research Personnel; Research Project Grants; Resources; Scientist; Secure; Series; Students; System; Talents; Teacher Professional Development; Training; Training Support; Universities; Update; Validation; Work; career; career development; cohort; design; experience; experimental study; human disease; improved; innovation; interest; knowledge translation; member; novel strategies; programs; recruit; senior faculty; skills; small molecule; tool; voucher

Project Summary/Abstract: Administrative Core The Administrative Core for the Nebraska Center for Molecular Target Discovery and Development will lead, implement, and support the Center's primary activities. These activities include creation of critical infrastructure for the (1) identification of disease targets, (2) generation of small molecules that manipulate those targets, and (3) analysis of preclinical models in which to evaluate the manipulation of those targets. Creation of that infrastructure will facilitate the Center's goal to deliver training and mentoring to promising new investigators focused on the discovery of new approaches that improve the treatment of disease. The Administrative Core will provide the organizational and programmatic leadership necessary to ensure the Center works efficiently toward attaining its goal, and is responsive to emerging research opportunities that improve its effectiveness. This will include implementing Center-wide activities – including an annual retreat, formal and informal training, and support for external seminar speakers – to create a collaborative research environment, promote the Center on a national level, and build a pool of talented doctoral and postdoctoral students in the laboratories of Center members. The Administrative Core will coordinate a faculty development plan that includes a Research Project Program and Pilot Grant Program designed to accelerate the transition of talented Project Leaders to independence and support the development of multi-investigator grants and program projects. Finally, the Administrative Core will serve as a coordination point between Center members and the Center's Scientific Cores. The Administrative Core will support a research program and related scientific cores to develop innovative tools for the detection and validation of molecular targets and provide guidance in experimental design and data analysis.

项目摘要/摘要：行政核心 内布拉斯加州分子靶标发现和开发中心的行政核心将领导， 实施和支持中心的主要活动，包括创建关键基础设施。 用于 (1) 识别疾病靶标，(2) 生成操纵这些靶标的小分子，以及 (3) 分析临床前模型，以评估这些目标的创建。 基础设施将促进该中心实现为有前途的新研究人员提供培训和指导的目标 专注于发现改善疾病治疗的新方法。 将提供必要的组织和计划领导，以确保中心有效运作 努力实现其目标，并对新出现的研究机会做出响应，以提高其有效性。 这将包括实施中心范围内的活动——包括年度务虚会、正式和非正式培训、 以及对外部研讨会演讲者的支持——创造一个协作研究环境，促进 国家级中心，建设国家级实验室博士和博士后人才库 中心成员将协调包括研究在内的教师发展计划。 项目计划和试点资助计划旨在加速有才华的项目领导者向 独立性并支持多研究者资助和计划项目的开发。 行政核心将作为中心成员和中心科学部门之间的协调点 核心。行政核心将支持研究计划和相关科学核心的开发。 用于检测和验证分子靶标的创新工具，并为实验提供指导 设计和数据分析。