Effects of Acculturation on Gestational Biology in Mexican-American Pregnant Women

文化适应对墨西哥裔美国孕妇妊娠生物学的影响

基本信息

批准号：
10386595
负责人：
Molly Maurer Fox
金额：
$ 8.81万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-06-15 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10386595
关键词：
Acculturation Address Administrative Supplement Affect American Anthropology Attitude Award Behavioral Biological Biological Factors Biological Markers Biological Sciences Biology COVID-19 COVID-19 pandemic Child Child Health Chronic Disease Consumption Country Development Development Plans Developmental Biology Disadvantaged Disease Early identification Ecology Education Educational process of instructing Elements Endocrine Ensure Environment Epidemiology Equation Exhibits Face Factor Analysis Faculty Failure Fetal Development Fetus Foundations Foxes Funding Future Generations Glucose Goals Health Health Status Hispanic Americans Hispanics Human Human Biology Immigrant Immune Individual Insulin Investigation K-Series Research Career Programs Laboratories Latina Latino Lead Leptin Life Light Link Lipids Literature Maternal and Child Health Measurement Measures Mentored Research Scientist Development Award Mentors Metabolic Methods Mexican Mexican Americans Minority Groups Modeling Mollies National Institute of Diabetes and Digestive and Kidney Diseases Obesity Paper Peer Review Phenotype Predisposition Pregnancy Pregnant Women Prevention strategy Process Property Psychometrics Psychoneuroimmunology Public Health Publishing Research Research Activity Research Personnel Resources Risk Role Social Environment Stress Structure Testing Time Training Training Activity Universities Vulnerable Populations Wages Woman base biobehavior biological systems career career development cohort disorder risk experience fetal fetal programming health disparity improved inclusion criteria instrument interest intergenerational laboratory facility migration motherhood next generation offspring population based pregnant prenatal prenatal stress preventive intervention prospective psychologic residence social social culture study population transmission process

项目摘要

ABSTRACT THIS PROPOSAL seeks additional salary support to compensate for career development activities missed due to COVID-19 disruptions from campus and daycare closures. There are no proposed changes to the research plan. RESEARCH SUMMARY. An important issue relates to the underlying cause(s) of epidemiologic observations that Latino immigrants exhibit a progressive decline in health (particularly obesity) over time and across generations. I suggest that the intergenerational escalation in obesity rates could be a consequence of acculturation-related biological changes in women. During pregnancy, these changes may be transmitted to the next generation (fetus) to influence offspring phenotypes that determine susceptibility for obesity (adiposity). A necessary step towards investigating this hypothesis is determining whether acculturation is associated with changes in aspects of gestational biology involved in fetal programming of adiposity. Also, I suggest that inconsistencies in the acculturation-health literature may relate to limitations of operationalization of the acculturation construct and failure to consider the modifying role of social context. Findings from this project will reveal new information about health status of vulnerable populations, which could lead to new avenues for early identification of at-risk individuals and prevention strategies to limit intergenerational perpetuation of disadvantage and poor health. I am on track to complete all the original K01 project aims by end of the award period. I already acquired NIDDK R03 funding and published 12 papers during my K01 period, with 2 more in peer review. ENVIRONMENT SUMMARY. At UCLA, I have my own biological laboratory located in the Life Sciences building, where I can process and store biosamples collected in my K01 research activities. Based in the UCLA Department of Anthropology and the Cousins Center for Psychoneuroimmunology, I have myriad resources, including an inter-disciplinary team of senior investigators to provide an intellectually productive environment, research staff, office, and laboratory facilities, and experiential education in state-of-the-art methods in human biology. CANDIDATE SUMMARY. I am primarily interested in the concepts of biological embedding of socio-ecological conditions, and the fetal origins of health and disease paradigm. My career goal is to become an independent investigator in human developmental biology with R01 funding, addressing key questions related to how an individual’s social and environmental ecology influences biological systems, and how biological links between generations affect the development of homeostatic mechanisms associated with chronic disease risk. CAREER DEVELOPMENT PLAN SUMMARY. I conducted formal coursework during Years 1-2 of the K01 award period. I am mentored by a team of prominent experts in their respective fields, led by Profs. Pathik Wadhwa (pre-transition of K-award from UCI to UCLA) and Christine Dunkel Schetter (post transition), leaders in the field of prenatal stress biology and fetal origins of disease, and receive specialized short-term training from a team of distinguished faculty at other universities.

抽象的该提案寻求额外的薪资支持，以补偿因以下原因而错过的职业发展活动： COVID-19 造成的校园和日托关闭造成的干扰研究计划没有拟议的变更。研究摘要。一个重要的问题涉及流行病学观察的根本原因。随着时间的推移和第一代人的健康状况（尤其是肥胖），拉丁裔移民的健康状况逐渐恶化。表明肥胖率的代际上升可能是与文化适应相关的结果女性在怀孕期间的生理变化可能会遗传给下一代（胎儿）。影响后代表型，从而决定肥胖的易感性（肥胖）。这个研究假设正在确定文化适应是否与某些方面的变化有关另外，我认为妊娠生物学与肥胖的胎儿编程有关。文化适应-健康文献可能与文化适应结构的操作化局限性有关未能考虑社会背景的改变作用该项目的调查结果将揭示新的信息。关于弱势群体的健康状况，这可能会为早期识别高危人群带来新的途径个人和预防策略，以限制劣势和不良健康状况的代际延续。有望在奖励期结束时完成所有最初的 K01 项目目标我已经获得了 NIDDK R03。在我的 K01 期间，我获得了资助并发表了 12 篇论文，其中还有 2 篇正在接受同行评审。环境摘要。在加州大学洛杉矶分校，我有自己的生物实验室，位于生命科学大楼，我可以在这里处理和存储在加州大学洛杉矶分校 K01 研究活动中收集的生物样本。人类学和考辛斯心理神经免疫学中心，我有无数的资源，包括由高级研究人员组成的跨学科团队，提供智力生产力环境、研究人员、办公室和实验室设施，以及人类生物学最先进方法的体验式教育。候选人摘要。我主要对社会生态学的生物嵌入概念感兴趣。我的职业目标是成为一个独立的人。人类发育生物学研究员，获得 R01 资助，解决与如何个体的社会和环境生态影响生物系统，以及生物系统之间的生物联系几代人影响与慢性病风险相关的稳态机制的发展。职业发展计划摘要。我在 K01 奖项的第 1-2 年期间进行了正式课程作业。我受到由 Pathik Wadhwa 教授领导的各自领域的杰出专家团队的指导。（K-award 从 UCI 过渡到 UCLA 之前）和 Christine Dunkel Schetter（过渡后），该领域的领导者产前应激生物学和胎儿疾病起源，并接受来自团队的专门短期培训其他大学的杰出教师。