Social adversity, gestational stress physiology, and birth outcomes in Hispanic Americans

西班牙裔美国人的社会逆境、妊娠应激生理学和出生结果

基本信息

批准号：
10222668
负责人：
Molly Maurer Fox
金额：
$ 11.7万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10222668
关键词：
Accounting Acculturation Address Adrenal Glands Adult Affect Age Alcohols Animal Model Biochemical Biological Biological Markers Biological Process Biology Birth Body Size Body mass index Child Childhood Chronic Disease Communities Data Development Dimensions Disadvantaged Discrimination Early identification Embryo Endocrine Environment Epidemiology Ethnic group Etiology Face Fetal Development Fetus Foundations Generations Gestational Age Goals Grant Health Hispanic Americans Hispanics Human Hypothalamic structure Immigrant Immigration Individual Inflammatory Intervention Interview Investments K-Series Research Career Programs Lasso Life Life Experience Light Linear Regressions Link Longitudinal Studies Maternal Age Measures Mediating Mediation Metabolic Metabolic dysfunction Metabolism Modeling Newborn Infant Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Participant Pattern Personal Satisfaction Phase Physiological Physiology Pituitary Gland Plasma Politics Poverty Predisposition Pregnancy Pregnancy Complications Pregnant Women Public Health Questionnaires Recording of previous events Reporting Research Research Personnel Risk Series Socioeconomic Status Stress Study models Techniques Telephone Tissues Tobacco Training Trauma Urine Victimization Woman adverse birth outcomes base cohort embryo/fetus experience fetal fetal programming follow-up girls health care availability health disparity illicit drug use intergenerational metabolic phenotype minority communities minority health multitask neonate novel obesity risk offspring offspring obesity postnatal pregnant prenatal prepregnancy prospective psychological distress sex social social culture social health determinants socioeconomics stressor theories trait trend

项目摘要

PROJECT SUMMARY/ABSTRACT This project addresses the epidemiological observation of increasing rates of obesity and type-2 diabetes mellitus (T2DM) across generations of Hispanic Americans. We propose a novel hypothesis to understand this phenomenon based on the concepts of fetal programming, social determinants of health, and biological embedding of life experience. Evidence suggests that the embryonic/fetal phase of life represents a critical window during which perturbations in the intrauterine biochemical environment affect development of body tissue patterning and metabolic function, influencing an individual’s lifelong health and susceptibility to obesity and T2DM. We posit that social and cultural stressors among Hispanic immigrant women may influence stress biology in ways that—for women who become pregnant—alter the biochemical environment to which the developing embryo/fetus is exposed. Hispanic immigrants are an exceptionally disadvantaged group who are vulnerable to high degrees of social adversity. We propose the original hypothesis that pregnant, Hispanic immigrant women’s perceived social adversity may alter stress-related biological processes to influence adiposity and metabolic phenotypes in the fetus, thereby pre-disposing the offspring to enhanced lifelong risk of obesity and T2DM. In a prospective, longitudinal study of 100 pregnant, Hispanic immigrant women established with the PI’s K-award, we will assess perceived social adversity from a series of original open-ended questions, Likert-scale items, and validated questionnaires, and relate these constructs to stress biology assessed from biosamples collected at two timepoints during pregnancy, and newborn body mass index percentiles (BMIP). Newborn body size has well-established correlations with childhood and adulthood adiposity and metabolic risk. In this context, we will pursue two specific aims. In Aim 1, we will examine how pregnant women’s perceived social adversity (immigration-related trauma, political victimization, discrimination) relates to four domains of gestational stress physiology: hypothalamic-pituitary-adrenal-placental, inflammatory, metabolic, and oxidative. In Aim 2, we will examine how pregnant women’s perceived social adversity relates to newborn BMIP. The expertise the PI gained in theory and analytic techniques for socio-cultural constructs, maternal-placental-fetal biology, adiposity and metabolism in her K01 training and research make her uniquely suited to successfully execute the R03 aims. Her K01 project, which focused on the possibility that acculturation may influence gestational biology, is logically extended in this R03 proposal by assessing other dimensions of socio-cultural stress, characterizing gestational stress physiology more comprehensively, and, importantly, directly measuring child outcomes. These endeavors will lay the foundation for an R01 proposal that will establish the PI as a fully independent investigator. Ultimately, these analyses may reveal new information about how experiences of social adversity can promote chronic disease states not only in the afflicted individuals but also across generations. Understanding the interplay between social, cultural, and biological mechanisms in minority health disparities may reveal new social, cultural, or biological targets of intervention to diminish inter-generational cycles of disadvantage and poor health in minority communities. This project emphasizes the possibility that investment in the well-being of girls and women can help alleviate health disparities.

项目概要/摘要该项目针对肥胖和 2 型糖尿病 (T2DM) 发病率上升的流行病学观察我们提出了一个新的假设来理解这一现象。胎儿编程的概念、健康的社会决定因素以及生活经验的生物嵌入。表明生命的胚胎/胎儿阶段是一个关键窗口，在此期间子宫内的扰动生化环境影响身体组织模式和代谢功能的发育，从而影响个体的我们认为西班牙裔人的终生健康状况以及对肥胖和 T2DM 的易感性是社会和文化压力因素。移民女性可能会通过改变怀孕女性的生化反应的方式影响应激生物学。发育中的胚胎/胎儿所处的环境尤其不利。我们提出最初的假设，即怀孕的西班牙裔。移民妇女所感受到的社会逆境可能会改变与压力相关的生物过程，从而影响肥胖和胎儿的代谢表型，从而使后代的终生肥胖风险增加 T2DM。在一项针对 100 名怀孕的西班牙裔移民女性的前瞻性纵向研究中，获得了 PI 的 K 奖。我们将从一系列原始的开放式问题、李克特量表项目和经过验证的项目中评估感知到的社会逆境问卷，并将这些结构与从两个时间点收集的生物样本评估的应激生物学相关联怀孕和新生儿体重指数百分位 (BMIP) 与新生儿体重有着明确的相关性。在此背景下，我们将在目标 1 中追求两个具体目标。研究孕妇如何看待社会逆境（与移民有关的创伤、政治受害、歧视）涉及妊娠应激生理学的四个领域：下丘脑-垂体-肾上腺-胎盘，在目标 2 中，我们将研究孕妇如何看待社会逆境。与新生 BMIP 相关的 PI 在社会文化建构的理论和分析技术方面获得的专业知识， K01 培训和研究中的母体-胎盘-胎儿生物学、肥胖和新陈代谢使她特别适合她成功执行了 R03 目标，该项目重点关注文化适应可能产生影响的可能性。妊娠生物学，通过评估社会文化压力的其他方面，在 R03 提案中得到逻辑扩展，更全面地描述妊娠应激生理学特征，更重要的是，直接测量儿童的结局。这些努力将为 R01 提案奠定基础，该提案将把 PI 确立为完全独立的研究者。最终，这些分析可能会揭示有关社会逆境经历如何促进慢性疾病的新信息。疾病状态不仅存在于受影响的个体中，而且存在于不同代际之间的相互作用中。少数民族健康差异的文化和生物机制可能揭示新的社会、文化或生物目标该项目旨在减少少数民族社区弱势和健康状况不佳的代际循环。强调对女孩和妇女福祉的投资可能有助于缩小健康差距。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Sociopolitical stressors are associated with psychological distress in a cohort of Latina women during early pregnancy.

社会政治压力源与拉丁裔女性怀孕早期的心理困扰有关。

DOI：
发表时间：
2023-09
期刊：
影响因子：
2.3
作者：
Wiley, Kyle S;Knorr, Delaney A;Chua, Kristine J;Garcia, Samantha;Fox, Molly M
通讯作者：
Fox, Molly M

The future of evolutionary medicine: sparking innovation in biomedicine and public health.

进化医学的未来：激发生物医学和公共卫生领域的创新。

DOI：
发表时间：
2023
期刊：
影响因子：
0
作者：
Natterson;Aktipis, Athena;Fox, Molly;Gluckman, Peter D;Low, Felicia M;Mace, Ruth;Read, Andrew;Turner, Paul E;Blumstein, Daniel T
通讯作者：
Blumstein, Daniel T

How a pregnant woman's relationships with her siblings relate to her mental health: a prenatal allocare perspective.

孕妇与兄弟姐妹的关系如何与其心理健康相关：产前同种护理的观点。

DOI：
发表时间：
2022
期刊：
影响因子：
0
作者：
Fox, Molly;Wiley, Kyle S
通讯作者：
Wiley, Kyle S

What Do Your Neighbors Think About You? How Perceived Neighbor Attitudes Toward Latinos Influence Mental Health Among a Pregnant Latina Cohort.

你的邻居怎么看你？

DOI：
发表时间：
2023-06-30
期刊：
影响因子：
0
作者：
Chua, Kristine J;Knorr, Delaney A;Jimenez, Janelly;Francia, Arlene;Rojas, Valeria;Garcia, Jhoana Infante;Fox, Molly
通讯作者：
Fox, Molly

Contact with caregivers is associated with composition of the infant gastrointestinal microbiome in the first 6 months of life.

与护理人员的接触与婴儿出生后 6 个月内胃肠道微生物群的组成有关。

DOI：
发表时间：
2024-04
期刊：
影响因子：
0
作者：
Wiley, Kyle S;Gregg, Andrew M;Fox, Molly M;Lagishetty, Venu;Sandman, Curt A;Jacobs, Jonathan P;Glynn, Laura M
通讯作者：
Glynn, Laura M