Methods for Selective Organic Synthesis based on Ionic Catalysts

基于离子催化剂的选择性有机合成方法

• 批准号: 10386162
• 负责人: F. Dean Toste
• 金额: $ 2.1万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-03 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10386162
• 关键词: Air; Alkenes; Anions; Boronic Acids; Carbon; Catalysis; Chemistry; Development; Equipment; Fluorine; Funding; Goals; Methods; Molecular; Natural Products; Nuclear Magnetic Resonance; Organic Synthesis; Parents; Preparation; Reaction; Research; Research Personnel; Therapeutic; Transition Elements; Work; analog; base; catalyst; enantiomer; improved; instrumentation; parent project; pi bond; preservation; programs; tool

Methods for Selective Organic Synthesis based on Ionic Catalysts Project Summary The major goal of this research program is to develop catalytic enantioselective transformations based on transition metal and chiral anion catalysis that will be broadly applicable to the preparation of therapeutically relevant organic molecules. Towards this end, new enantioselective reactions of carbon-carbon π-bonds are proposed, with a major emphasis placed on the development of enantioselective sp3-C-F bond construction. Additionally, reactions that generate or employ available building blocks, such as alkenes and boronic acids, will be targeted. These methods will be exploited in the enantioselective construction of fluorinated building blocks, heterocycles and natural product analogs. Thus, we anticipate that the proposed air and moisture tolerant transformations will provide synthetic chemists and biomedical researchers with additional tools for molecular synthesis and for single enantiomer construction.

基于离子催化剂的选择性有机合成方法 项目概要 该研究计划的主要目标是开发基于 过渡金属和手性阴离子催化将广泛应用于治疗药物的制备 为此，人们开发了碳-碳π键的新对映选择性反应。 提出，重点放在对映选择性 sp3-C-F 键结构的开发上。 此外，生成或使用可用结构单元（例如烯烃和硼酸）的反应将 这些方法将用于氟化结构单元的对映选择性构建， 因此，我们预计所提出的产品具有耐空气性和耐湿性。 转化将为合成化学家和生物医学研究人员提供分子生物学的额外工具 合成和单一对映体构建。