NEURAL SYSTEMS OF BODY FLUID HOMEOSTASIS AND AVP RELEASE

体液稳态和 AVP 释放的神经系统

• 批准号: 2234319
• 负责人: J Thomas Cunningham
• 金额: $ 11.43万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-06-01 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2234319
• 关键词: adrenergic receptor; afferent nerve; arginine vasopressin; baroreceptors; blood pressure; body fluids; carotid sinus; catecholamines; electrophysiology; electrostimulus; experimental brain lesion; hemostasis; histology; hormone regulation /control mechanism; laboratory rat; neural information processing; neural inhibition; neuroendocrine system; neurons; neurophysiology; norepinephrine; oxytocin; peripheral nervous system; supraoptic nucleus

Body fluid homeostasis is critically important for normal physiological function of the cardiovascular system. Recent evidence suggests that t he diagonal band of Broca (DBB) participates in the central regulation of body fluid balance. More specifically, the DBB relays information from high pressure baroreceptors to vasopressin releasing neurons in the supraoptic nucleus of the hypothalamus (SON) and influences drinking behavior. However, it has not been determined how information from peripheral baroreceptors reaches the DBB and how this input modifies the activity of the DBB neurons. The aim of the experiments in this proposal is to determine the role of the DBB and other neural systems in the baroreceptors control of vasopressin release from the SON. This aim will be addressed by conducting in vivo electrophysiological experiments which will examine 1) the effects of peripheral baroreceptor afferent stimulation on magnocellular supraoptic neurons, 2) the role of noradrenergic receptors within the DBB in the baroreceptor-mediated inhibition of vasopressin SON neurons, 3) the source and influence of the noradrenergic innervation of the DBB. This work will provide new information about the organization of the pathways within the central nervous system that mediate the baroreceptor regulation of body fluid homeostasis. This information may provide a model of how baroreceptor afferents regulate neuroendocrine, autonomic and behavioral systems and how this regulation is altered by the development of disease states.

体液稳态对于正常生理至关重要 心血管系统的功能。 最近的证据表明， Broca对角带（DBB）参与身体的中枢调节 液体平衡。 更具体地说，DBB 从高层传递信息 视上区的加压素释放神经元的压力感受器 下丘脑核 (SON) 并影响饮酒行为。 然而，尚未确定来自外围设备的信息如何 压力感受器到达 DBB 以及该输入如何改变压力感受器的活动 DBB 神经元。 本提案中实验的目的是确定 DBB 和其他神经系统在压力感受器控制加压素中的作用 从 SON 释放。 这一目标将通过在体内进行 电生理学实验将检查 1）的影响 大细胞视上的周围压力感受器传入刺激 神经元，2）DBB内去甲肾上腺素能受体在 压力感受器介导的加压素 SON 神经元抑制，3) 来源 DBB 去甲肾上腺素能神经支配的影响。 这项工作将提供有关组织的新信息 中枢神经系统内介导压力感受器的通路 体液稳态的调节。 此信息可以提供模型 压力感受器传入如何调节神经内分泌、自主神经和 行为系统以及这种调节如何随着行为的发展而改变 疾病状态。