MAMMOTROPE DIFFERENTIATING PEPTIDE

乳腺肌分化肽

• 批准号: 2204031
• 负责人: L STEPHEN FRAWLEY
• 金额: $ 18.89万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-04-01 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2204031
• 关键词: antibody neutralization test; antimitotics; cell differentiation; cell growth regulation; developmental nutrition; growth factor; immunoglobulins; ion exchange chromatography; laboratory rat; mammary gland; messenger RNA; milk; molecular biology; newborn animals; nutrition related tag; peptide hormone; peptides; pituitary gland; postpartum; prolactin; protein purification; protein sequence; secretion; somatotropin; tissue /cell culture

There is now strong evidence that mammalian milk, particularly that formed during the early postpartum period, is more than just a source of nutrition an immunoglobulins for the young. In fact, it is also a concentrated "cocktail' of hormones and growth factors that has the potential to regulate the development and growth of the neonate. Many of these hormonal agents are found at high concentrations in milk, an are absorbed and efficiently transferred to the neonatal circulation in biologically active forms. Surprisingly, there is a dearth of direct evidence to support a requisite physiologic role for these absorbed hormones in neonatal development. Our group has recently obtained strong evidence that a low molecular weight, milk peptide regulates the differentiation of PRL- secreting cells in neonatal rats. Our goal now becomes one of identifying the milk-borne factor that initiates this process, elucidating the mechanism by which it acts, and establishing its physiologic role in normal development. We should like to stress, however, that our proposed studies have even broader implications in that our approach should be viewed as a prototypic strategy for establishing whether any maternal signal delivered via milk plays a requisite role in infant growth and development. Information derived from these studies will be essential for fully evaluating the importance of breast feeding and for the rational design of supplements to human infant formulas.

现在有强有力的证据表明哺乳动物牛奶，尤其是形成的哺乳动物 在产后早期，不仅是营养的来源 年轻人的免疫球蛋白。 实际上，它也是集中的 “激素和生长因素的鸡尾酒”有可能 规范新生儿的发展和增长。 其中许多荷尔蒙 在牛奶中发现的药物是高浓度的，一个被吸收的，并且 有效地转移到生物活性的新生儿循环中 表格。 令人惊讶的是，缺乏直接证据来支持 这些吸收的激素在新生儿中的必要生理作用 发展。 我们的小组最近获得了有力的证据，表明低 分子量，牛奶肽调节PRL-的分化 在新生大鼠中分泌细胞。 我们的目标现在成为确定的 启动此过程的牛奶 - 传播因素，阐明了 它起作用的机制，并在正常情况下确立其生理作用 发展。 但是，我们要强调我们提出的研究 具有更广泛的含义，因为我们的方法应被视为 建立是否传递任何母体信号的原型策略 通过牛奶在婴儿的生长和发育中起着必要的作用。 从这些研究中得出的信息对于完全至关重要 评估母乳喂养的重要性和对合理设计的重要性 补充人类婴儿配方。