Tiny Test Tubes to Tackle Antimicrobial Resistance in Dairy Farming in India

微型试管解决印度奶牛场的抗菌素耐药性问题

• 批准号: 133962
• 金额: $ 7.49万
• 依托单位: CAPILLARY FILM TECHNOLOGY LTD
• 依托单位国家: 英国
• 项目类别: Knowledge Transfer Network
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=133962
• 关键词: Tiny; Test; Tubes; Tackle; Antimicrobial

VisionOur long-term goal is to tackle the challenge of rising AMR levels that leads to reduced milk production through hard-to-treat mastitis in dairy cattle (cutting family income), and untreatable human infections. Although India is the world's largest milk producing nation, most dairy farms are not industrialised- instead thousands of small farms provide milk locally. Family income is dependent on healthy cows and buffalo, yet bacterial infection (mastitis) is becoming harder to treat as widespread antibiotic use drives high AMR levels. We will support this vulnerable population of rural farmers by designing simple AMR testing products that can be used outside central labs. AMR spreads rapidly and drug-resistant bacteria not only harms animals and limits productivity but also presents a major human health threat, especially in India where families live in close proximity to dairy cattle.Without monitoring and accurate data, it is impossible to control AMR, but AMR is difficult and expensive to measure. Current tests are slow (\>2 days) and laborious and can only be performed in microbiology laboratories limiting the number of samples. CFT has developed a simple, miniature version of standard tests which not only simplifies lab testing, but allows testing outside centralised labs. Results are recorded by smartphone camera and test devices can be mass-produced at low cost (CFT already manufactures <£0.50/test) allowing large-scale deployment to new and emerging markets such as India. Mastitis costs farmers £10 per infected cow through treatment and lost productivity. This technology can help tackle AMR in dairy farming in India.Feasibility studyThis phase 1 study aims to design specific products to help tackle AMR in dairy farming in India. Working with Indian partners we will optimise a product with maximum potential to benefit the most vulnerable people affected by drug-resistant mastitis.Envisaged impacts in IndiaCost-effective monitoring of AMR is essential, locally to permit selection of effective antibiotics, and nationally to support government networks. Family farms will avoid economic losses from poorly treated mastitis, and our innovation also aligns with the Indian Government's recently published National Action Plan for Dairy Development. Increased productivity will allow some farmers to access expanding urban markets and a pathway to export; but export requires more stringent AMR monitoring and antibiotic control. Public health will benefit from AMR surveillance by lowering risk of drug-resistant human infections. CFT will partner with Indian biotechnology industry to co-develop products, driving job creation and expanding innovation capacity.

愿景我们的长期目标是应对抗生素耐药性水平上升的挑战，尽管印度是世界上最大的牛奶生产国，但抗生素耐药性水平上升导致难以治疗的奶牛乳腺炎（减少家庭收入）和无法治疗的人类感染导致牛奶产量减少。大多数奶牛场都没有实现工业化，而是有数以千计的小型农场在当地提供牛奶。家庭收入依赖于健康的奶牛和水牛，但随着抗生素的广泛使用导致抗生素耐药性水平升高，细菌感染（乳腺炎）变得越来越难治疗。这通过设计可在中心实验室之外使用的简单 AMR 测试产品，AMR 会迅速传播，耐药细菌不仅会伤害动物并限制生产力，还会对人类健康构成重大威胁，特别是在家庭居住的印度。靠近奶牛。如果没有监测和准确的数据，就不可能控制 AMR，但 AMR 的测量既困难又昂贵，目前的测试速度慢（> 2 天）且费力，只能在微生物实验室中进行，限制了 AMR 的检测。样本数量。 CFT 开发了一种简单的微型版本的标准测试，不仅简化了实验室测试，而且允许在集中实验室之外进行测试，结果由智能手机摄像头记录，并且测试设备可以低成本批量生产（CFT 的制造成本已低于 0.50 英镑/台）。测试）允许在印度等新兴市场进行大规模部署，每头感染乳腺炎的奶牛的治疗成本和生产力损失需要花费 10 英镑。可行性研究这项第一阶段研究。旨在设计具体产品来帮助解决印度奶牛养殖中的抗菌素耐药性问题，我们将与印度合作伙伴合作，优化一种具有最大潜力的产品，以造福于受耐药性乳腺炎影响的最脆弱人群。预期对印度的影响抗菌素耐药性监测具有成本效益。至关重要的是，在当地允许选择有效的抗生素，在全国范围内支持政府网络，家庭农场将避免因乳腺炎治疗不当而造成的经济损失，而且我们的创新也符合印度政府最近发布的国家乳制品发展行动计划。一些农民进入不断扩大的城市市场和出口途径；但出口需要更严格的 AMR 监测和抗生素控制，CFT 将与印度生物技术行业合作，从 AMR 监测中受益。开发产品，推动创造就业机会并扩大创新能力。