Novel Macaque Breeding Runs at the New Iberia Research Center

新伊比利亚研究中心开展新型猕猴育种工作

• 批准号: 10374603
• 负责人: Francois J Villinger
• 金额: $ 350.65万
• 依托单位: UNIVERSITY OF LOUISIANA AT LAFAYETTE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2024-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10374603
• 关键词: AIDS/HIV problem; African Green Monkey; Air; Animals; Antibody Therapy; Award; Behavioral; Blood Circulation; Breeding; COVID-19 testing; Colorectal; Containment; Cost Savings; Development; Electricity; HIV; Heating; Housing; Human Resources; Louisiana; Macaca; Macaca fascicularis; Macaca mulatta; Maintenance; Monkeys; Mucous Membrane; Municipalities; National Institute of Allergy and Infectious Disease; Pan Genus; Pathogenesis; Primates; Rain; Research; Running; SIV Vaccines; Sanitation; Signal Transduction; Site; Stress; Taxes; Testing; Texas; Therapeutic; United States National Institutes of Health; Universities; Vaccines; Vagina; Viral; Water; base; design; experience; imaging capabilities; male; microbicide; nonhuman primate; novel; offspring; pandemic disease; prevent; programs; vaccine evaluation; vaccine-induced antibodies

The New Iberia Research Center (NIRC) at the University of Louisiana at Lafayette is aiming to expand its macaque breeding capacity by the construction of 2 multi-run housing buildings complete with roofing, electricity, water, heating and air circulation. This type of building has been specifically designed and extensively tested for macaque housing/breeding at another facility in Texas, attesting to the adequacy, ease of maintenance and duration of construction. Each building unit will comprise 20 indoor/outdoor runs able to easily accommodate up to 20 breeder animals each for a total capacity of ~800 breeders and their offsprings. This expansion is critical to accommodate the rapidly increasing research programs at NIRC as well as the support of NIAID VRC and SVEU HIV/AIDS focused programs. NIRC supports many both onsite and collaborative programs on lentiviral pathogenesis supported by state of the art imaging capabilities including a whole body to signal cell analysis approach, therapeutic approaches aimed at curing HIV, and an extensive program to prevent mucosal viral acquisition via protective experimental vaccines, vaginal and colorectal microbicides. In addition, NIRC has been a key contributor to the testing of COVID-19 vaccines and antibody treatments. The latter pandemic has severely depleted the supply of research macaques and NIRC has been expanding its colonies via the addition of 2200 nonhuman primates over the past 5 years. This has been accommodate by gradually repurposing chimpanzee housing into breeding and research space, but this conversion has reached its limits and NIRC has reached it maximum capacity as far as monkey housing, in part due to the addition of a 2 new colonies of Mauritian cynomolgus macaques and African green monkeys and the award of a NIAID SIV Vaccine Evaluation Unit award. The rationale for adding this particular type of housing is based on its versatility, low maintenance and cost savings on manpower: Located in Southern Louisiana, NIRC has the ability to house rhesus macaques outdoors year-round for breeding purposes, though the traditional corncrib cage design, while outstanding for sanitation and the behavioral development of macaques, with limited hierarchical stress, also has a number of drawbacks that the proposed new buildings will avoid, including the lack secondary containment, adequate protection for the occasional subzero days as recently experienced and a “rain tax” imposed by our municipal water ordinance. Corncrib housing currently supports breeding groups of up to 10 rhesus macaques in typical harem configuration with 1 male per corncrib. Use of larger runs as proposed, will enable the expansion of >1500 macaque breeders on site, maximizing utilization of proven breeder males. With over 8,500 nonhuman primates on site, NIRC is the largest primate facility in the US, and while not directly supported by NIH, has a rapidly expanding research program and readily available space for expansion, we submit that NIRC is an ideal site for expansion of macaque breeding in support of NIH research.

路易斯安那大学拉斐特分校的新伊比利亚研究中心 (NIRC) 旨在扩大其研究范围 通过建造 2 座多用途住宅楼来提高猕猴繁殖能力，这些住宅楼配有屋顶、电力、 水、供暖和空气循环经过专门设计和广泛测试。 德克萨斯州另一处设施的猕猴饲养/繁殖，证明设施充足、易于维护和 每个建筑单元将包含 20 个室内/室外跑道，可轻松容纳 每只 20 只种畜，总容量约为 800 只种畜及其后代。这种扩张至关重要。 适应 NIRC 快速增长的研究项目以及 NIAID VRC 和 SVEU 艾滋病毒/艾滋病重点项目 NIRC 支持许多有关慢病毒的现场和合作项目。 最先进的成像能力支持发病机制，包括全身信号细胞分析 方法、旨在治愈艾滋病毒的治疗方法以及预防粘膜病毒的广泛计划 此外，NIRC 还通过保护性实验疫苗、阴道和结直肠杀微生物剂获得了这些疫苗。 后者是 COVID-19 疫苗和抗体治疗测试的关键贡献者。 由于研究猕猴的供应耗尽，NIRC 一直在通过增加 2200 只猕猴来扩大其栖息地 在过去的五年里，非人类灵长类动物逐渐改变了黑猩猩的用途，从而解决了这一问题。 住房转变为育种和研究空间，但这种转变已达到极限，NIRC 已达到极限 猴舍的最大容量，部分原因是增加了 2 个新的毛里求斯猴群 食蟹猴和非洲绿猴以及 NIAID SIV 疫苗评估单位奖。 添加这种特殊类型住房的理由是其多功能性、低维护成本和成本 节省人力：NIRC 位于路易斯安那州南部，有能力在户外饲养恒河猴 全年用于养殖目的，虽然采用传统的玉米笼设计，但卫生条件出色 而猕猴的行为发展，在等级压力有限的情况下，也存在一些步履蹒跚的问题。 拟议的新建筑将避免（包括缺乏二次安全壳）对人员提供充分保护 最近偶尔出现零度以下的天气，以及我们的市政水法令征收的“雨水税”。 Corncrib 住房目前支持最多 10 只恒河猴的繁殖群体，采用典型的后宫配置 每个玉米笼饲养 1 只雄性猕猴，按照建议使用更大的饲养场，将能够扩大 1500 只以上的猕猴饲养场。 NIRC 现场有超过 8,500 只非人类灵长类动物，可最大限度地利用经过验证的雄性灵长类动物。 美国最大的灵长类动物设施，虽然没有得到 NIH 的直接支持，但其研究规模正在迅速扩大 计划和现成的扩展空间，我们认为 NIRC 是扩展的理想场所 支持 NIH 研究的猕猴育种。