Development and Testing of a Depression-Specific Behavioral Activation Mobile App Paired with Nicotine Replacement Therapy Sampling for Smoking Cessation Treatment Via Primary Care

开发和测试抑郁症特异性行为激活移动应用程序，并结合尼古丁替代疗法采样，通过初级保健进行戒烟治疗

• 批准号: 10364683
• 负责人: Jennifer Renee Dahne
• 金额: $ 20.08万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10364683
• 关键词: Address; Adherence; Adult; Area; Behavioral; Cellular Phone; Clinical; Clinical Practice Guideline; Clinical Research; Communication; Depressed mood; Development; Development Plans; Ensure; Environment; Evidence based treatment; Funding; General Population; Goals; Grant; Group Psychotherapy; Health Technology; Individual; Intervention; Interview; Knowledge; Leadership; Light; Manuscripts; Mental Depression; Mental Health; Mental Health Services; Mentors; Mentorship; Motivation; National Institute of Drug Abuse; Nicotine; Outcome; Participant; Patients; Persons; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacotherapy; Physical Dependence; Physicians; Physiological; Positioning Attribute; Preparation; Primary Care Physician; Primary Health Care; Procedures; Professional Competence; Psychological Dependence; Public Health; Publications; Randomized; Relapse; Research; Research Personnel; Research Project Grants; Resources; Risk Factors; Sampling; Smoker; Smoking; Smoking Cessation Intervention; Structure; Technology; Testing; Time; Tobacco use; Training; Visit; Withdrawal; Work; Writing; addiction; arm; base; behavioral health intervention; career; career development; catalyst; cigarette smoking; comorbidity; depressive symptoms; design; effectiveness clinical trial; evidence base; experience; feasibility testing; implementation science; innovation; intervention delivery; intervention refinement; laboratory experience; mHealth; mobile application; mobile computing; nicotine replacement; novel; patient oriented research; post-doctoral training; psychologic; public health priorities; recruit; screening; secondary outcome; smartphone Application; smoking cessation; smoking prevalence; symposium; therapy development; translational potential; treatment as usual; usability

PROJECT SUMMARY/ABSTRACT Cigarette smoking remains a public health priority and is highly prevalent among those with depressive symptoms. Depression-specific cessation interventions are necessary but currently lacking, particularly treatments that can be readily disseminated within primary care. Tailoring a simple, straightforward evidence- based, depression-specific cessation intervention, such as Behavioral Activation (BA), for delivery via a mobile app holds the potential to overcome existing treatment barriers and reach many depressed smokers who are not currently receiving necessary treatment. The integration of such an app with pharmacological treatment that has similar translational potential, such as nicotine replacement therapy (NRT) sampling, offers a dual-pronged approach targeting both psychological and physical dependence risk factors for relapse. The present research project will develop, systematically evaluate, and clinically test an integrated cessation intervention comprised of a depression-specific BA smartphone mobile app (Goal2Quit) and NRT sampling that will meet the unmet need for an easily disseminable, evidence-based, depression-specific cessation intervention for delivery via primary care. Specific aims include: 1) usability testing of Goal2Quit (N=5) and refinements prior to feasibility testing, 2) a single-arm feasibility test (N=12) of the integrated Goal2Quit + NRT Sampling intervention via primary care and subsequent refinements of the intervention, and 3) a small-scale RCT (N=180) within primary care of Goal2Quit + NRT Sampling vs. TAU to provide effect size estimates for a larger RCT. The research environment, facilities, and resources at MUSC are ideally suited for mentored career development in addiction research. K23 training objectives are to: 1) broaden training in smoking cessation intervention development, focused on the comorbidity of tobacco use and depression, 2) acquire essential knowledge and experience in large-scale, effectiveness clinical trials for smoking cessation, 3) cultivate mobile app development experience by gaining expertise in patient-focused, user-centered mHealth intervention development, 4) develop expertise in Primary Care-Mental Health Integration, focused on implementation science and dissemination of psychological and behavioral health interventions via primary care, and 5) expand essential career skills in scientific communication, including grant writing, conference presentations, and manuscript preparation. Structured mentorship from Drs. Matthew Carpenter, Brian Hitsman, Kenneth Ruggiero, Vanessa Diaz, and Elizabeth Garrett-Mayer will ensure training goals are met. The candidate’s long-term career goal is to direct a research portfolio that: 1) develops novel smoking cessation interventions simultaneously targeting mental health and addiction, 2) delivers these novel interventions in the real world (e.g., primary care), and 3) utilizes technology, to overcome treatment barriers. The training proposed herein is designed to develop expertise across all three of these areas, represents a clear progression from prior training, and would not be possible without this K23.

项目概要/摘要 吸烟仍然是公共卫生的一个优先事项，并且在抑郁症患者中非常普遍 针对抑郁症的戒烟干预措施是必要的，但目前尤其缺乏。 可以在初级保健中轻松传播的治疗方法。 基于抑郁症的戒烟干预措施，例如行为激活 (BA)，通过手机进行 该应用程序有潜力克服现有的治疗障碍，并惠及许多不吸烟的抑郁症患者 目前正在接受必要的治疗，将此类应用程序与药物治疗相结合。 类似的转化潜力，例如尼古丁替代疗法（NRT）采样，提供了双管齐下的方法 本研究针对复发的心理和身体依赖风险因素。 该项目将开发、系统评估和临床测试综合戒烟干预措施，包括 针对抑郁症的 BA 智能手机移动应用程序 (Goal2Quit) 和 NRT 采样将满足未满足的需求 寻求一种易于传播、基于证据、针对抑郁症的戒烟干预措施，通过初级 具体目标包括：1) Goal2Quit (N=5) 的可用性测试和可行性测试之前的改进，2) 通过初级保健对综合 Goal2Quit + NRT 抽样干预进行单臂可行性测试 (N=12) 以及随后对干预措施的改进，以及 3) 初级保健内的小规模随机对照试验 (N=180) Goal2Quit + NRT 抽样与 TAU 为更大的 RCT 研究环境提供效果大小估计。 MUSC 的设施和资源非常适合 K23 成瘾研究的指导职业发展。 培训目标是： 1) 扩大戒烟干预发展培训范围，重点关注 烟草使用和抑郁症的共病，2）获得大规模的必要知识和经验， 戒烟有效性临床试验，3) 通过获得 以患者为中心、以用户为中心的移动医疗干预开发方面的专业知识，4) 发展初级领域的专业知识 护理与心理健康一体化，重点关注心理和心理健康的科学实施和传播 通过初级保健进行行为健康干预，以及 5) 扩展科学领域的基本职业技能 沟通，包括资助写作、会议演示和手稿准备。 Matthew Carpenter、Brian Hitsman、Kenneth Ruggiero、Vanessa Diaz 和 Elizabeth 博士的指导 加勒特-梅耶尔将确保候选人的长期职业目标是指导一项研究。 组合：1）开发新颖的戒烟干预措施，同时针对心理健康和 成瘾，2）在现实世界中提供这些新颖的干预措施（例如初级保健），以及 3）利用技术， 克服治疗障碍本文提出的培训旨在培养所有三个方面的专业知识。 这些领域的进步代表了之前培训的明显进步，如果没有 K23，这是不可能实现的。

项目成果

Longer duration of smoking abstinence is associated with waning cessation fatigue.

较长的戒烟时间与戒烟疲劳的减弱有关。

• 发表时间: 2019
• 影响因子: 4.1
• 作者: Heckman, Bryan W;Cummings, K Michael;Stoltman, Jonathan J K;Dahne, Jennifer;Borland, Ron;Fong, Geoffrey T;Carpenter, Matthew J
• 通讯作者: Carpenter, Matthew J

Effects of brief exposure to misinformation about e-cigarette harms on twitter: a randomised controlled experiment.

在推特上短暂接触有关电子烟危害的错误信息的影响：一项随机对照实验。

• 发表时间: 2021
• 影响因子: 2.9
• 作者: Wright, Caroline;Williams, Philippa;Elizarova, Olga;Dahne, Jennifer;Bian, Jiang;Zhao, Yunpeng;Tan, Andy S L
• 通讯作者: Tan, Andy S L

State Tobacco Excise Taxation, Comprehensive Smoke-free Air Laws, and Tobacco Control Appropriations as Predictors of Smoking Cessation Success in the United States.

州烟草消费税、全面的无烟空气法和烟草控制拨款作为美国戒烟成功的预测因素。

• 发表时间: 2020
• 作者: Dahne, Jennifer;Nahhas, Georges J;Wahlquist, Amy E;Cummings, K Michael;Carpenter, Matthew J
• 通讯作者: Carpenter, Matthew J

Gender parity and homophily in the Drug and Alcohol Dependence editorial process.

药物和酒精依赖编辑过程中的性别平等和同质性。

• 发表时间: 2022-07-01
• 影响因子: 4.2
• 作者: Schick, Melissa R;Tomko, Rachel L;Maralit, Anna M;Afzal, Zubair;Squeglia, Lindsay M;Freda, Agnieszka;Porrino, Linda;Dahne, Jennifer;McClure, Erin A;Strain, Eric C
• 通讯作者: Strain, Eric C

An Open-label Pilot Study of NicoBloc as a Novel Smoking Cessation Intervention.

NicoBloc 作为新型戒烟干预措施的开放标签试点研究。

• 发表时间: 2023-03-06
• 作者: Chichester, Keith R;Sisson, Michelle L;Chana, Sofia Mildrum;Wolford;Hugley, Mickeah J;Hawes, Elizabeth S;Palenski, Paige;Nguyen, Angela;Dahne, Jennifer;Hendricks, Peter S;Cropsey, Karen L
• 通讯作者: Cropsey, Karen L