Core A: Administrative Core

核心A：行政核心

• 批准号: 10351936
• 负责人: Bevin P. Engelward
• 金额: $ 19.45万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10351936
• 关键词: Achievement; Adoption; Advocacy; Carcinogens; Chemicals; Collaborations; Communication; Communities; Computing Methodologies; Data; Data Analyses; Dependence; Devices; Dimethylnitrosamine; Discipline; Disease; Educational process of instructing; Educational workshop; Engineering; Ensure; Environmental Health; Environmental Protection; Exposure to; Family; Felis catus; Filtration; Fostering; Future; Goals; Government Agencies; Hazardous Chemicals; Hazardous Substances; Health; Human; Infrastructure; Intervention; Investigator-Initiated Research; Knowledge; Lead; Leadership; Massachusetts; Mentors; Methods; Mission; Municipalities; Mutagens; N-nitrosodimethylamine; National Institute of Environmental Health Sciences; National Toxicology Program; Nitrosamines; Persons; Play; Public Health; Research; Risk; Role; Safety; Science; Source; Suggestion; Sum; Superfund; System; Technology; Technology Transfer; Training; Training Support; Translating; Translational Research; Translations; Tribes; Underrepresented Students; United States Environmental Protection Agency; United States Food and Drug Administration; Water; Work; career; community engagement; data management; data sharing; data streams; drinking water; experience; high throughput screening; improved; innovation; meetings; member; next generation; novel; posters; programs; remediation; restoration; sensor; success; superfund chemical; superfund site; tribal organization; wasting; water treatment

PROJECT SUMMARY/ABSTRACT – ADMINISTRATIVE CORE N-nitrosamines are a family of chemicals that include some of the most potent mutagens known. N-nitrosamines are a major concern for people who live near the Olin Chemical Superfund Site, which is contaminated with millions of gallons of waste containing high levels of N-nitrosodimethylamine (NDMA), a probable human carcinogen. NDMA is also a concern of the Passamaquoddy Tribe, because the water treatment methods used for their drinking water are known to lead to formation of NDMA. The mission of the Administrative Core is to enable a Systems Approach wherein impact on public health is made possible via a network of interactions and interdependencies among Projects, Cores, and stakeholders. The resulting ‘MIT SRP Interactome’ results from research meetings, enrichment activities, workshops, retreats, poster sessions, trainee collaboration meetings, and meetings with stakeholders. Team building will be further strengthened via adoption and enhancement of team science values. Translation will be fostered via support of Project and Core leaders in developing and executing their Investigator Initiated Research Translation plans and by continual input and suggestions from the Administrative Core leadership, and in particular the Research Translation Coordinator. In addition to its Systems Approach, other innovative goals include facilitation of bidirectional communication with the National Toxicology Program to enable the MIT team to cater technologies to meet the needs for high-throughput screens for chemical safety and working with the Community Engagement Core (CEC) to deploy N-nitrosamine sensors and remediation devices that destroy N-nitrosamines. Specific Aim 1 is to lead and coordinate in order to achieve a robust programmatic ‘MIT SRP Interactome’ that will give rise to results and deliverables that contribute to the protection of human health from hazardous substances. Specific Aim 2 is to partner and promote by translating knowledge and technologies to local, state, national, and tribal organizations. Specific Aim 3 is to achieve a broader impact via dissemination of knowledge and by building a better future for the next generation of leaders in environmental health sciences. Communication and data sharing will be further strengthened by the Data Management and Analysis Core (DMAC), which will deliver computational methods for integrating data streams from across disciplines in order to contribute to a better understanding of risk, improved ability to predict disease, and new opportunities for interventions. The Administrative Core will also work closely with the Research Experience and Training Coordination Core (RETCC) to coordinate training and support for trainees. Taken together, the Administrative Core is the cog that drives the program forward by creating tight collaborations and interdependencies within the MIT SRP and with its local, state and national stakeholders, that together enable MIT SRP solutions that give rise to improved public health.

项目概要/摘要——行政核心 N-亚硝胺是一类化学物质，其中包括一些已知最有效的诱变剂。 是居住在奥林化学超级基金站点附近的人们的一个主要担忧，该站点受到了 数百万加仑的废物含有高浓度的 N-亚硝基二甲胺 (NDMA)，可能是人类 NDMA 也是 Passamaquoddy 部落关注的一个问题，因为使用的水处理方法。 众所周知，他们的饮用水会导致 NDMA 的形成。 启用一种系统方法，通过交互网络对公共卫生产生影响 项目、核心和利益相关者之间的相互依赖关系产生于“MIT SRP Interactome”。 研究会议、丰富活动、研讨会、务虚会、海报会议、实习生协作会议、 以及与利益相关者的会议将通过采用和增强来进一步加强团队建设。 团队科学价值观将通过项目和核心领导者的支持来培养和发展。 他们的研究者发起的研究翻译计划以及来自以下机构的持续投入和建议 行政核心领导层，特别是研究翻译协调员。 系统方法，其他创新目标包括促进与国家的双向沟通 毒理学计划使麻省理工学院团队能够提供满足高通量筛选需求的技术 化学安全并与社区参与核心 (CEC) 合作部署 N-亚硝胺传感器 具体目标 1 是领导和协调，以消除 N-亚硝胺。 实现强大的程序化“MIT SRP Interactome”，这将产生以下结果和可交付成果： 为保护人类健康免受有害物质的侵害做出贡献 具体目标 2 是合作。 并通过将知识和技术转化为地方、州、国家和部落来促进 具体目标 3 是通过传播知识来实现​​更广泛的影响。 为环境健康科学的下一代领导者建设更美好的未来。 数据管理和分析核心将进一步加强沟通和数据共享 （DMAC），它将提供用于整合跨学科数据流的计算方法 有助于更好地了解风险、提高预测疾病的能力以及新的机会 行政核心还将与研究经验和培训部门密切合作。 协调核心（RETCC）负责协调培训人员的培训和支持，行政部门。 核心是通过在内部建立紧密的协作和相互依赖来推动项目向前发展的齿轮。 MIT SRP 及其地方、州和国家利益相关者共同打造 MIT SRP 解决方案， 从而改善公共卫生。