Admin Core

管理核心

• 批准号: 10477448
• 负责人: Alfred L. George
• 金额: $ 7.3万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10477448
• 关键词: Academic Medical Centers; Accountability; Achievement; Adherence; Adoption; Animal Model; Awareness; Biological Models; Clinical; Communication; Communities; Community Outreach; Conflict (Psychology); Data; Databases; Deposition; Disputes; Education; Educational Activities; Ensure; Epilepsy; Evaluation; Foundations; Genes; Genetic; Goals; Hospitals; Human; Industry; Institution; International; Ion Channel; Ion Channel Gating; Leadership; Manuscripts; Mediation; Neurons; Parents; Participant; Patient advocacy; Persons; Physicians; Policies; Publications; Reporting; Reproducibility; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Schedule; Scientist; Site; Time; United States National Institutes of Health; Variant; childhood epilepsy; cost effective; data sharing networks; genetic variant; high throughput technology; industry partner; meetings; new technology; patient engagement; repository; success; symposium; voltage; web site

PROJECT SUMMARY – ADMINISTRATIVE CORE We propose to create a multi-institutional CHANNELOPATHY-ASSOCIATED EPILEPSY RESEARCH CENTER that will combine high-throughput technologies for functional evaluation of epilepsy-associated ion channel gene variants with high-content human neuron and animal model systems. The Center will be comprised of an integrated set of 3 research projects and 2 scientific cores involving a synergistic mixture of academic and industry scientists. Specifically, our Center will involve the efforts of more than 20 scientists and physicians affiliated with 5 academic medical centers, 3 free standing research hospitals, and 2 industry partners working together to investigate the functional consequences of variants in voltage-gated ion channel genes that are the most frequently discovered cause of genetic epilepsy. The research will be interdisciplinary and multi-faceted involving novel technologies and unique resources. The assembled investigative team is collegial and collaborative and this will contribute to the overall success. The Administrative Core will be responsible for managing and coordinating all major activities of the Center in the most efficient and cost effective manner to accomplish our major goals and to achieve milestones. This administrative oversight will involve coordination of all research components of the Center, communication among all participants, and engagement of other stakeholders from various professional and non-professional community partners. The aims of the Administrative core are: 1) to manage and coordinate all administrative and collaborative activities of the Center; 2) to facilitate communication across participating institutions and community partners; and 3) to enable public awareness of Center activities and ensure resource sharing.

项目摘要——行政核心 我们建议建立一个多机构的通道病相关癫痫研究 该中心将结合高通量技术对癫痫相关离子进行功能评估 该中心将建立具有高含量人类神经元和动物模型系统的通道基因变异。 由 3 个研究项目和 2 个科学核心组成，涉及以下领域的协同组合： 具体来说，我们的中心将涉及 20 多名科学家和科学家的努力。 隶属于 5 个学术医疗中心、3 个独立研究医院和 2 个行业的医生 合作伙伴共同研究电压门控离子通道中变异的功能后果 基因是遗传性癫痫最常见的原因，这项研究将是跨学科的。 所组建的调查团队是多方面的，涉及新颖的技术和独特的资源。 共同协作，这将有助于整体成功。 行政核心将负责管理和协调中心的所有主要活动 实现我们的主要目标和里程碑的最有效和最具成本效益的方式。 行政监督将涉及中心所有研究部门的协调、沟通 所有参与者的参与，以及来自各种专业和非专业的其他利益相关者的参与 社区合作伙伴的目标是： 1) 管理和协调所有行政工作。 和中心的协作活动；2) 促进参与机构之间的沟通和 社区合作伙伴；3) 提高公众对中心活动的认识并确保资源共享。