Research and Mentoring on Neurocognitive Disparities in Aging

衰老过程中神经认知差异的研究和指导

基本信息

批准号：
10351110
负责人：
Maria Marquine
金额：
$ 18.47万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-15 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10351110
关键词：
Acculturation Administrative Supplement Age Aging Alzheimer disease detection Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Area Award Awareness Biological Process COVID-19 pandemic effects California Cellular Phone Clinical Clinical Psychology Cognitive Cognitive aging Data Development Discrimination Early identification Environmental Risk Factor Fostering Funding HIV Hispanic Hispanic Populations Infrastructure International Intervention Joints K-Series Research Career Programs Language Latin America Latina Latino Population Leadership Mental Health Mentors Metabolic syndrome Midcareer Investigator Award in Patient-Oriented Research Minority Minority Groups Neurocognitive Neurocognitive Deficit Neuropsychological Tests Neuropsychology Not Hispanic or Latino Pilot Projects Population Positioning Attribute Principal Investigator Process Research Research Infrastructure Research Institute Research Personnel Research Project Grants Research Support Resources Risk Risk Factors Role Science Scientist Seeds Time Training Training Programs Training and Infrastructure Underrepresented Minority United States United States National Institutes of Health Universities Work bilingualism career dementia risk disadvantaged background dysbiosis early-career faculty education research experience gut microbiome health literacy high risk high school improved innovation minority trainee mobile computing neurobehavioral patient oriented research programs protective factors skills social culture stem tool tool development

项目摘要

PROJECT SUMMARY The proposed K24 Midcareer Investigator Award in Patient-Oriented Research aims to best enable the Principal Investigator, Dr. María Marquine, to advance research on neurocognitive disparities in aging and Alzheimer’s Disease and Related Dementias (ADRDs) among Hispanics/Latinos/as/x (henceforth Hispanics). Dr. Marquine’s research program has centered around two major themes: 1) the identification of risk and protective factors for neurocognitive decline among older Hispanics with and without HIV, and 2) the development of tools for the accurate identification of neurocognitive impairment among Spanish-speakers in the United States. More recently, she has extended this latter focus to include the use of ubiquitous mobile technology for the identification of ADRD risk. Dr. Marquine is passionate about mentoring and supporting the advancement of early career scientists, particularly those from underrepresented minority (URM) backgrounds. Approximately 80% of her mentees have been from disadvantaged backgrounds, and her mentees have spanned various career stages, from high-school to early career faculty. She is currently a co-Investigator on two NIA-funded research education programs, the San Diego Alzheimer’s Disease-Resource Center for Minority Aging Research (AD-RCMAR) and the University of California San Diego (UCSD) Advancing Diversity through Aging Research (ADAR) program, and Deputy Director of an R25 Research Education Program on aging and HIV. She is also a mentor in the UCSD Hispanic Center of Excellence, several NIH-funded T32 training programs housed at UCSD, and the San Diego State University (SDSU)/UCSD Joint Doctoral Program in Clinical Psychology. Attaining a Midcareer Investigator Award would allow Dr. Marquine protected time to continue advancing her research program in neurocognitive disparities and ADRD, deepen her commitment to mentor junior clinical scientists in the conduct of research in this area, and obtain formal training in mentoring and leadership skills. The award would also provide support for the development of neuropsychological normative standards to detect neurocognitive impairment associated with ADRDs among older Spanish-speakers, which is a necessary step toward the advancement of ADRD research in this understudied group. In her research and mentoring activities, Dr. Marquine will leverage resources available within three major research centers at UCSD, namely, the Stein Institute for Research on Aging, the Shiley-Marcos Alzheimer’s Disease Research Center, and the HIV Neurobehavioral Research Program. Together, these research centers have built and maintain a highly effective research and training infrastructure that will serve as an important resource for Dr. Marquine’s own research program and that of her mentees.

项目概要拟议的 K24 职业生涯中期研究者奖以患者为导向的研究旨在最大程度地帮助校长研究员 María Marquine 博士将推进衰老和阿尔茨海默氏症神经认知差异的研究西班牙裔/拉丁裔/as/x（以下简称西班牙裔）的疾病和相关痴呆症 (ADRD)。研究计划围绕两大主题：1）识别风险和保护因素感染和未感染艾滋病毒的老年西班牙裔人的神经认知能力下降，以及 2) 开发工具准确识别美国西班牙语使用者的神经认知障碍。最近，她将后一个重点扩展到包括使用无处不在的移动技术 Marquine 博士热衷于指导和支持 ADRD 风险的识别。早期职业科学家，特别是那些来自代表性不足的少数族裔 (URM) 背景的科学家。她的学员中有80%来自弱势群体，而且她的学员跨越了不同的领域她目前是两个 NIA 资助项目的联合研究员。研究教育计划，圣地亚哥阿尔茨海默病少数族裔老龄化研究资源中心 (AD-RCMAR) 和加州大学圣地亚哥分校 (UCSD) 通过老龄化研究促进多样性 (ADAR) 项目，R25 老龄化和艾滋病毒研究教育项目副主任。 UCSD 西班牙裔卓越中心的导师，在 UCSD 举办的多个 NIH 资助的 T32 培训项目，以及圣地亚哥州立大学 (SDSU)/加州大学圣地亚哥分校临床心理学联合博士项目。职业中期研究员奖将为 Marquine 博士提供受保护的时间来继续推进她的研究神经认知差异和 ADRD 项目，加深了她对指导初级临床科学家的承诺在该领域进行研究，以及指导和领导技能方面的正式培训。还将为神经心理学规范标准的制定提供支持，以检测老年西班牙语使用者中与 ADRD 相关的神经认知障碍，这是一个必要的步骤在她的研究和指导活动中，推动 ADRD 研究的发展。 Marquine 博士将利用加州大学圣地亚哥分校三个主要研究中心（即斯坦因研究中心）的可用资源衰老研究所、希利-马科斯阿尔茨海默病研究中心和艾滋病毒这些研究中心共同建立并维持了一个高效的神经行为研究项目。研究和培训基础设施将成为 Marquine 博士自己研究的重要资源计划和她的学员的计划。