Treatment of Circadian Disruption from Shiftwork in Older Adults

老年人轮班工作造成的昼夜节律紊乱的治疗

基本信息

批准号：
10343696
负责人：
Jeanne F Duffy
金额：
$ 40.58万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-03-15 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10343696
关键词：
Accidents Acute Address Adopted Adoption Adverse effects Affect Age Aging American Beds Biological Clocks Caffeine Circadian Dysregulation Circadian Rhythm Sleep Disorders Circadian Rhythms Commuting Development Drowsiness Elderly Environment Exercise Fatigue Focus Groups Future Gastrointestinal Diseases Grant Health Home Hormones Hour Hydrocortisone Impairment Individual Injury Intervention Laboratories Laboratory Study Lead Life Light Lighting Malignant Neoplasms Medical Melatonin Mental Depression Metabolic Diseases Middle Insomnia Moods Nurses Occupations Older Population Participant Perception Performance Performance at work Phototherapy Physiological Productivity Quality of life Randomized Reporting Research Design Risk Safety Schedule Sleep Sleep Deprivation Sleep disturbances Societies Stimulant Stress Surveys Testing Translating Treatment Efficacy Wakefulness Work acceptability and feasibility adverse outcome alertness base cardiovascular disorder risk circadian efficacy evaluation feasibility testing field study improved inattention pressure safety outcomes sex shift work sleep difficulty sleep regulation social willingness

项目摘要

Project Summary/Abstract The American workforce is aging; by 2020, a quarter of the workforce will be over 55 years old. As sleep and circadian challenges are magnified in older adults, countermeasures for these workers, especially those working night shifts, are imperative. Night shift work leads to a mismatch between the timing of circadian rhythms and the timing of the work/sleep schedule. This in turn leads to sleepiness during nighttime work, increasing the risk of performance errors and injuries. Night shift workers also typically sleep in the morning after returning from work, thereby arising 8+ h prior to their next night shift. They thus begin work with a great amount of sleep pressure due to prolonged wakefulness, further exacerbating their sleepiness. While a number of strategies to improve sleep and alertness in shift workers have been tested, few such studies have been carried out in older adults. In the previous grant period we tested a sleep timing strategy in a lab study in older adults: scheduling sleep to begin in the early afternoon and extend into the evening, such that awakening occurs 1-2 h prior to the next night shift. We found that the older participants were able to spend 8 h in bed in the afternoon-evening, they got significantly more (and less disrupted) sleep than participants who slept ad lib, their night shift alertness and performance was increased, and they showed reduced levels of the stress hormone cortisol. We now propose to translate that laboratory-tested sleep intervention to an operational environment and evaluate its efficacy, feasibility and acceptability. In a Field Trial, we will conduct a randomized study of the 8h afternoon-evening sleep intervention in older nurses to evaluate its efficacy for improving sleep duration/quality and performance/alertness across 3 consecutive night shifts. Exploratory analyses will focus on stress, subjective fatigue, mood, and quality of life. We will also Survey a large group of older night shift workers to determine their typical sleep timing, factors influencing their sleep timing and duration following night shifts, and challenges to an 8h afternoon-evening sleep episode, to explore the feasibility of disseminating and implementing this intervention among a broad population of older night workers. To further understand how 8h afternoon-evening sleep impacts on- and off-shift activities in “real life” and barriers to adoption of such a schedule, we will carry out Focus Groups where the feasibility and acceptability of the sleep intervention will be explored. Inadequate sleep is one of the most challenging problems affecting the 3 million older American night workers. Given our increasing understanding of how sleep deficiency contributes to adverse performance, health, safety, and quality of life, it is imperative to translate successful laboratory countermeasures and test them in operational settings. This rigorously designed study will evaluate such a countermeasure and test its efficacy, feasibility and acceptability in older nightshift workers.

项目概要/摘要美国劳动力正在老龄化；到2020年，四分之一的劳动力年龄将超过55岁。老年人的昼夜节律挑战被放大，针对这些工人，特别是那些工作的人的对策夜班，势在必行夜班工作会导致昼夜节律的时间不匹配。工作/睡眠时间的安排反过来会导致夜间工作时犯困，从而增加风险。夜班工人通常也会在早上下班回家后睡觉。工作，因此他们在下一次夜班前 8 小时以上起床，因此他们在大量睡眠的情况下开始工作。由于长时间的清醒压力，进一步加剧了他们的困倦，而一些策略。改善轮班工人的睡眠和警觉性已经过测试，但很少有针对老年人的此类研究在上一个资助期间，我们在一项针对老年人的实验室研究中测试了一种睡眠计时策略：日程安排。睡眠从下午早些时候开始，一直持续到晚上，这样就可以在睡觉前 1-2 小时醒来。我们发现，年龄较大的参与者能够在下午至晚上在床上度过 8 个小时。与那些随意睡眠的参与者相比，他们的睡眠时间更长（而且受到的干扰更少），他们的夜班警觉性和他们的表现得到了提高，并且压力荷尔蒙皮质醇的水平降低了。我们现在建议将经过实验室测试的睡眠干预转化为操作环境，并在现场试验中，我们将对其进行随机研究，以评估其有效性、可行性和可接受性。对老年护士进行8小时下午-晚上睡眠干预，评估其改善睡眠的功效探索性分析将重点关注连续 3 个夜班的持续时间/质量和表现/警觉性。我们还将对一大群老年夜班工人进行调查。确定他们的典型睡眠时间、影响其睡眠时间的因素以及夜班后的持续时间，以及对下午 8 小时至晚上睡眠时间的挑战，以探索传播和在广大老年夜班工人中实施这项干预措施，以进一步了解 8 小时工作制的效果。下午和晚上的睡眠会影响“现实生活”中的上下班活动，并阻碍采用这种睡眠模式。日程安排上，我们将开展焦点小组讨论，讨论睡眠干预的可行性和可接受性被探索。睡眠不足是影响 300 万美国老年夜班工人的最具挑战性的问题之一。鉴于我们越来越了解睡眠不足如何导致不良表现、健康、安全，和生活质量，必须转化成功的实验室对策并在操作中进行测试这项经过严格设计的研究将评估这种对策并测试其有效性、可行性和有效性。老年夜班工人的可接受性。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Do sleep disturbances mediate the association between work-family conflict and depressive symptoms among nurses? A cross-sectional study.

睡眠障碍是否介导护士工作与家庭冲突与抑郁症状之间的关联？

DOI：
发表时间：
2017-10
期刊：
影响因子：
0
作者：
Zhang, Y;Duffy, J F;De Castillero, E Ronan
通讯作者：
De Castillero, E Ronan

Interventions to improve the sleep of nurses: A systematic review.

改善护士睡眠的干预措施：系统评价。

DOI：
发表时间：
2023-10
期刊：
影响因子：
2
作者：
Zhang, Yuan;Murphy, Jennifer;Lammers;Barger, Laura K;Lai, Yun;Duffy, Jeanne F
通讯作者：
Duffy, Jeanne F

Objective Diagnosis of Circadian Rhythm Disorders.

昼夜节律紊乱的客观诊断。

DOI：
发表时间：
2023-03-01
期刊：
影响因子：
0
作者：
Giordano, Alessandra;Duffy, Jeanne;Epstein, Lawrence J;Pavlova, Milena K
通讯作者：
Pavlova, Milena K

Sleep tips for shift workers in the time of pandemic.

疫情期间轮班工人的睡眠技巧。

DOI：
发表时间：
2020
期刊：
影响因子：
0
作者：
Lammers;Murphy, Audra S;Wise, John;Duffy, Jeanne F
通讯作者：
Duffy, Jeanne F

Evaluation of sleep strategies between night shifts in actual shift workers.

实际轮班工人夜班之间睡眠策略的评估。

DOI：
发表时间：
2024-02
期刊：
影响因子：
4.1
作者：
Lammers;Qadri, Salim;Murphy, Audra;Ronda, Joseph M;Zhang, Yuan;Barger, Laura K;Duffy, Jeanne F
通讯作者：
Duffy, Jeanne F

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Jeanne F Duffy其他文献

Feasibility, effectiveness, and acceptability of an afternoon-evening sleep schedule in older nightshift workers

老年夜班工人下午-晚上睡眠时间表的可行性、有效性和可接受性

DOI：
10.1093/sleepadvances/zpae010
发表时间：
2024-02-07
期刊：
Sleep Advances: A Journal of the Sleep Research Society
影响因子：
0
作者：
L. Barger;Yuan Zhang;Heidi M Lammers;Davina Snoep;Audra S Murphy;B. Desnoyers;Jeanne F Duffy
通讯作者：
Jeanne F Duffy