Investigating the Influences of Sleep‐Wake Patterns and Gut Microbiome Development in Infancy on Rapid Weight Gain, an Early Risk Factor for Obesity
研究婴儿期睡眠唤醒模式和肠道微生物组发育对体重快速增加的影响,体重快速增加是肥胖的早期危险因素
基本信息
- 批准号:10337221
- 负责人:
- 金额:$ 72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-02-01 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:16S ribosomal RNA sequencing3 year oldAccountingAddressAdultAffectAgeAmericanAmericasAntibioticsBacteroides fragilisBifidobacteriumBirthBreast FeedingCardiometabolic DiseaseCesarean sectionCharacteristicsChildChild HealthClinicalClinical TrialsCommunity DevelopmentsDataDevelopmentEcologyEnvironmental Risk FactorEpidemiologyEvidence based practiceExhibitsFamilyFirmicutesFutureGenus staphylococcusGrowthGrowth FactorHarvestHealthHome visitationHomeostasisHumanInfantInterventionLeadLifeLongitudinal observational studyLow incomeMediator of activation proteinMetabolicMetabolic PathwayMetabolismModelingMothersNeurologicObesityObesity EpidemicOutcomePatternPeriodicityPregnancyPreventionRegulationRiskRisk FactorsRoleRouteShapesSignal TransductionSleepStaphylococcus aureusStimulusTestingTimeVaginaWeightWeight GainWorkWorld Health Organizationactigraphyagedbasebeneficial microorganismbiobehaviorcircadiandisorder riskearly childhoodethnic diversityevidence based guidelinesexperiencefeedinggut microbiomegut microbiotaimprovedinfancyinfant adiposityinfant gut microbiomemature animalmicrobiome alterationmicrobiome researchnovelobesity developmentobesity in childrenobesity preventionobesity riskpathogenpoor sleepprenatalprepregnancypreventprospectiveracial diversityrapid infant weight gainrapid weight gainrole modelsleep qualitytherapy designtime intervaltime use
项目摘要
PROJECT SUMMARY
Rapid Weight Gain (RWG; >+0.67 change in weight-for-age Z-score) during the first 6 months of life is a strong
determinant of early life and persistent obesity, and cardiometabolic diseases. Obesity affects 18.5% of American
children aged 2-19 years and 8.1% of those <2 years. While short sleep duration and poor sleep quality are
important early risk factors for the development of childhood obesity and are major targets of national prevention
efforts, their impact on early RWG is less understood. Sleep-wake patterns in infancy, such as the development
of the 24-hr circadian sleep-wake rhythm, an important neurological milestone, may be especially important for
influencing risk of RWG. Disruptions to circadian sleep-wake rhythmicity are associated with greater adiposity
and its development primarily occurs in the first 6 months of life, the same critical, predictive timeframe as RWG.
The human gut microbiome (GM) is also established during this time to promote growth through energy
harvesting and metabolic signaling. Emerging data suggest that sleep may alter the GM and infant metabolism,
which ultimately may impact obesity. To date, most GM research has focused on the independent effects of
vaginal vs. cesarean birth delivery, antibiotic use, and breastfeeding vs. formula feeding on childhood obesity
risk. However, evidence is limited on if sleep-wake pattern and GM development interact to influence RWG.
Broadening our understanding of the GM role in obesity risk in early life to include the establishment of sleep-
wake patterns will improve our ability to intervene at a young age and prevent the onset of obesity. Therefore,
we propose to prospectively follow 192 mother-infant pairs prenatally through 12 months (3 weeks, 8 weeks, and
3, 6, 9 and 12 months) of life and assess the magnitude and timing of infant sleep-wake patterns and GM
development as predictors of RWG. This project will implement a novel conceptual framework that incorporates
the GM and sleep-wake patterns as metabolic contributors for RWG. The underlying theoretical and analytical
framework of this work will be based on the Ecological Model of Growth (EMG) that focuses on child, maternal,
family, and environmental factors that contribute to a child’s growth and combines human ecology and
epidemiology to evaluate broader interactions among these factors that influence child health outcomes. EMG
factors will be included as covariates in models of sleep and GM development on RWG. Our study will address
the following aims: 1- Investigate associations of infant sleep-wake patterns with subsequent RWG at 6 months
and weight gain at 12 months using time-varying effect models; 2- Investigate associations of GM development
with RWG at 6 months and weight at 12 months; and 3- Evaluate whether temporal interactions exist between
infant sleep-wake patterns and GM development, and if these relations influence RWG. Project findings will
inform future clinical interventions that include sleep and GM approaches to reduce the risk of RWG in infancy.
This pipeline of work will ultimately lead to the development of evidence-based guidelines for sleep and GM
development to prevent obesity through the identification of crucial developmental time intervals for RWG.
项目概要
出生后前 6 个月体重快速增加(RWG;年龄别体重 Z 值变化 >+0.67)是一个强有力的指标
早年和持续性肥胖的决定因素,肥胖影响着 18.5% 的美国人。
2-19岁儿童,其中2岁以下儿童占8.1%,睡眠时间短、睡眠质量差。
儿童肥胖发生的重要早期危险因素,是国家预防的主要目标
婴儿期的睡眠-觉醒模式,例如发育
24 小时昼夜节律的睡眠-觉醒节律是一个重要的神经学里程碑,对于
影响 RWG 的风险。昼夜节律性睡眠-觉醒节律的破坏与肥胖程度增加有关。
它的发展主要发生在生命的前 6 个月,与 RWG 相同的关键、可预测的时间范围。
人类肠道微生物群(GM)也在这段时间建立,通过能量促进生长
新出现的数据表明,睡眠可能会改变 GM 和婴儿的新陈代谢,
迄今为止,大多数转基因研究都集中在其独立影响上。
阴道分娩与剖腹产、抗生素使用以及母乳喂养与配方奶喂养对儿童肥胖的影响
然而,关于睡眠-觉醒模式和 GM 发育是否相互作用影响 RWG 的证据有限。
扩大我们对 GM 在生命早期肥胖风险中的作用的理解,包括建立睡眠-
醒来模式将提高我们在年轻时进行干预的能力并预防肥胖的发生。
我们建议对 192 对母婴进行产前 12 个月(3 周、8 周和
3、6、9 和 12 个月)并评估婴儿睡眠-觉醒模式和 GM 的程度和时间
作为 RWG 的预测因素,该项目将实施一个新颖的概念框架,其中包含
GM 和睡眠-觉醒模式作为 RWG 的代谢贡献者 基础理论和分析。
这项工作的框架将基于生态增长模型(EMG),重点关注儿童、孕产妇、
家庭和环境因素有助于儿童的成长,并将人类生态学和
流行病学来评估影响儿童健康结果的这些因素之间更广泛的相互作用。
我们的研究将解决 RWG 睡眠和 GM 发育模型中的协变量。
目标如下: 1- 研究婴儿睡眠-觉醒模式与随后 6 个月时 RWG 的关联
以及使用时变效应模型 12 个月时的体重增加;2- 研究 GM 发育的关联;
6 个月时的 RWG 和 12 个月时的体重;以及 3-评估两者之间是否存在时间相互作用。
婴儿睡眠-觉醒模式和 GM 发育,以及这些关系是否会影响 RWG 项目的研究结果。
为未来的临床干预措施提供信息,包括睡眠和 GM 方法,以降低婴儿期 RWG 的风险。
这一工作流程最终将导致睡眠和 GM 的循证指南的制定
通过确定 RWG 的关键发育时间间隔来预防肥胖。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Megan Elise Petrov其他文献
Megan Elise Petrov的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Megan Elise Petrov', 18)}}的其他基金
Investigating the Influences of Sleep‐Wake Patterns and Gut Microbiome Development in Infancy on Rapid Weight Gain, an Early Risk Factor for Obesity
研究婴儿期睡眠-觉醒模式和肠道微生物组发育对体重快速增加的影响,体重快速增加是肥胖的早期危险因素
- 批准号:
9912021 - 财政年份:2020
- 资助金额:
$ 72万 - 项目类别:
Investigating the Influences of Sleep‐Wake Patterns and Gut Microbiome Development in Infancy on Rapid Weight Gain, an Early Risk Factor for Obesity
研究婴儿期睡眠唤醒模式和肠道微生物组发育对体重快速增加的影响,体重快速增加是肥胖的早期危险因素
- 批准号:
10088468 - 财政年份:2020
- 资助金额:
$ 72万 - 项目类别:
Investigating the Influences of Sleep‐Wake Patterns and Gut Microbiome Development in Infancy on Rapid Weight Gain, an Early Risk Factor for Obesity
研究婴儿期睡眠唤醒模式和肠道微生物组发育对体重快速增加的影响,体重快速增加是肥胖的早期危险因素
- 批准号:
10557236 - 财政年份:2020
- 资助金额:
$ 72万 - 项目类别:
相似国自然基金
3-6岁人工耳蜗植入儿童汉语句法习得机制
- 批准号:32371110
- 批准年份:2023
- 资助金额:50 万元
- 项目类别:面上项目
3-6岁学龄前儿童碘膳食参考摄入量的研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
3-6岁儿童情绪调节能力的追踪研究:亲子互动同步性与儿童气质的共同作用
- 批准号:
- 批准年份:2021
- 资助金额:56 万元
- 项目类别:面上项目
3-6岁幼儿易怒发展的追踪研究:认知调节策略及神经机制
- 批准号:
- 批准年份:2020
- 资助金额:24 万元
- 项目类别:青年科学基金项目
贫困地区0-3岁婴幼儿非认知能力干预的影响及其作用机理研究
- 批准号:72003112
- 批准年份:2020
- 资助金额:24 万元
- 项目类别:青年科学基金项目
相似海外基金
Novel MRI coil technology for safe imaging of children with implants
新型 MRI 线圈技术可对植入儿童进行安全成像
- 批准号:
10639661 - 财政年份:2023
- 资助金额:
$ 72万 - 项目类别:
How reasoning contributes to preschoolers’ prosocial development
推理如何促进学龄前儿童亲社会发展
- 批准号:
10645706 - 财政年份:2023
- 资助金额:
$ 72万 - 项目类别:
Longitudinal Academic Performance in Children with a History of Neonatal Abstinence Syndrome
有新生儿戒断综合症病史的儿童的纵向学业表现
- 批准号:
10608149 - 财政年份:2022
- 资助金额:
$ 72万 - 项目类别:
Prenatal Exposure to NIS inhibitors, Iodine Deficiency, and Thyroid Dysfunction
产前接触 NIS 抑制剂、碘缺乏和甲状腺功能障碍
- 批准号:
10453337 - 财政年份:2022
- 资助金额:
$ 72万 - 项目类别:
The longer-term impact of prenatal exposure to SARS-CoV-2 infection and the COVID-19 vaccine on behavior, cognition, and brain functioning in the child
产前接触 SARS-CoV-2 感染和 COVID-19 疫苗对儿童行为、认知和大脑功能的长期影响
- 批准号:
10687018 - 财政年份:2022
- 资助金额:
$ 72万 - 项目类别: