Integrating experimental and field studies to understand PFAS bioaccumulation and impact in aquatic food webs

结合实验和现场研究，了解 PFAS 的生物累积及其对水生食物网的影响

基本信息

批准号：
10337309
负责人：
Antonio J. Planchart
金额：
$ 17.12万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-28 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10337309
关键词：
Address Affect Age Alligators Biology Chemical Structure Chemicals Clinical Cohort Studies Complement Consumption Controlled Study Diet Ecosystem Environment Environmental Engineering technology Environmental Health Environmental Risk Factor Environmental Science Evaluation Exposure to Fishes Food Food Webs Foundations Fresh Water Fright Future Generations Goals Hazard Assessment Health Human Individual Investigation Kinetics Laboratories Laboratory Study Life Link Measures Modeling Movement Nature Organism Outcome Persons Phase Plants Poly-fluoroalkyl substances Production Reporting Research Research Project Grants Resources Risk Management Rivers Safety Sampling Source Structure Superfund Testing Tissues Toxic effect Uncertainty Water Work Zebrafish aquatic organism aqueous base bioaccumulation chemical release dietary drinking water experimental study exposed human population exposure pathway exposure route field study immune function laboratory experiment nutrition predictive modeling uptake

项目摘要

ABSTRACT (Environmental Science and Engineering) Research Project 3 Per- and polyfluoroalkyl substances (PFAS) are chemicals that are of emerging concern because they are widely released into the environment where they tend to be persistent and bioaccumulative. Some PFAS are associated with adverse health outcomes in people, and production of a limited number of them (e.g., PFOA and PFOS) has been phased out due to these concerns. However, there are approximately 5,000 PFAS, and there is considerable uncertainty regarding the human health and environmental safety of these compounds because most PFAS have never been tested. Because these compounds are routinely released into waterways that serve as sources of drinking water and nutrition via consumption of fish and aquatic wildlife, there is an immediate need to better understand their environmental fate and effects. As concerns about PFAS in the environment are beginning to grow, there are increasing reports of the presence of these compounds in water and in aquatic organisms, but our understanding of their bioaccumulation potential and toxicity to aquatic life is limited. This project specifically addresses concerns about the bioaccumulation and toxicity of PFAS in aquatic food webs. One major goal of this project is to compare the accumulation of PFAS (12 different compounds) in a food web context by comparing aqueous uptake in primary producers (periphyton), primary consumers (mayflies), and secondary consumers (zebrafish) in the laboratory. A second major goal is to understand the potential for different compounds to move trophically in food webs by measuring the movement of different compounds from periphyton to mayflies to fish. Only by doing controlled studies in the laboratory can we systematically understand the bioaccumulation dynamics of these different compounds based on their different chemical structures. The next major goal of this work is to compare the toxicity of different PFAS to zebrafish. While zebrafish is a recognized model for human health studies, this project utilizes the deep understanding of this species' biology to explore the consequences of PFAS exposure to fish. The project will compare the toxicity of 12 different compounds in zebrafish using traditional toxicity approaches (exposures from water) but will be unique in that it will also assess the potential for dietary PFAS exposures to contribute to toxicity because in nature, exposures are likely to both PFAS in water and in the diet. Finally, these laboratory studies will be complemented by field investigations of PFAS in local waterways and in the tissues of aquatic fish and wildlife. This work is prompted by local contamination of a major watershed by a PFAS manufacturing plant and associated concerns about real-world exposures. Specifically, the project will measure PFAS in fish and wildlife (alligators) that are potential dietary exposure routes of these contaminants to people. Together, the project will provide much needed information about the bioaccumulation, toxicity, and exposure profiles of PFAS in the aquatic environment.

抽象的（环境科学与工程）研究项目3 全氟烷基物质和多氟烷基物质 (PFAS) 是新近引起关注的化学品，因为它们被广泛使用释放到环境中，它们往往具有持久性和生物累积性。一些 PFAS 是相关的对人类健康产生不利影响，且其产量有限（例如 PFOA 和 PFOS）由于这些问题已被逐步淘汰。然而，大约有 5,000 种 PFAS，并且有这些化合物的人类健康和环境安全存在相当大的不确定性，因为大多数 PFAS 从未经过测试。因为这些化合物通常会被释放到服务水道中作为通过食用鱼类和水生野生动物获得饮用水和营养的来源，需要更好地了解它们的环境命运和影响。由于对环境中 PFAS 的担忧随着这些化合物开始生长，越来越多的报告表明这些化合物存在于水和水生生物中。生物体，但我们对其生物累积潜力和对水生生物的毒性的了解有限。这该项目专门解决了对水生食物网中 PFAS 生物累积和毒性的担忧。该项目的一个主要目标是比较食物网中 PFAS（12 种不同化合物）的积累通过比较初级生产者（附生生物）、初级消费者（蜉蝣）和实验室中的二级消费者（斑马鱼）。第二个主要目标是了解通过测量不同化合物在食物网中的营养移动附生生物到蜉蝣到鱼类。只有在实验室做对照研究才能系统地了解这些不同化合物基于其不同化学结构的生物蓄积动力学。这这项工作的下一个主要目标是比较不同 PFAS 对斑马鱼的毒性。虽然斑马鱼是该项目是公认的人类健康研究模型，利用了对该物种生物学的深刻理解探讨鱼类接触 PFAS 的后果。该项目将比较 12 种不同的毒性使用传统的毒性方法（暴露于水中）对斑马鱼中的化合物进行检测，但其独特之处在于还将评估饮食中 PFAS 暴露导致毒性的可能性，因为在自然界中，暴露水和饮食中可能都含有 PFAS。最后，这些实验室研究将得到现场研究的补充调查当地水道以及水生鱼类和野生动物组织中的 PFAS。这项工作被提示 PFAS 制造厂对主要流域的局部污染以及相关问题真实世界的曝光。具体来说，该项目将测量鱼类和野生动物（鳄鱼）中潜在的 PFAS 人们通过饮食接触这些污染物的途径。该项目将共同提供急需的有关水生环境中 PFAS 的生物累积、毒性和暴露概况的信息。