National Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination Resource

国家显微镜和成像研究中心：大脑技术集成和传播资源

基本信息

批准号：
10334513
负责人：
Mark H Ellisman
金额：
$ 112.88万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-01 至 2025-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10334513
关键词：
3-Dimensional Achievement Actins Animal Model BRAIN initiative Behavior Biomedical Technology Brain Brain imaging Chemicals Communities Community Outreach Complement Complex Data Analyses Data Set Disease Electron Microscopy Elements Endoplasmic Reticulum Extracellular Matrix Genetic Goals Histologic Image Imaging Device Imaging Techniques Imaging technology Immersion In Situ Information Technology Investigation Label Learning Light Maps Measures Methods Microscopy Mitochondria Molecular Molecular Probes National Center for Research Resources National Institute of General Medical Sciences Nerve Tissue Neurons Neurosciences Physiological Population Preparation Process Recovery Research Research Personnel Research Project Grants Resolution Resource Sharing Resources Roentgen Rays Role Sampling Scanning Electron Microscopy Specimen Stains Structure Structure-Activity Relationship Subcellular Anatomy Techniques Technology Training Ultramicrotomy Vertebral column Vesicle Visualization Work X ray microscopy base brain cell brain research brain tissue cell type computerized tools connectome cost cryogenics cyber infrastructure data acquisition data dissemination data management data sharing deep learning imaging platform insight instrument instrumentation interest large scale data light microscopy microscopic imaging multimodal data multimodality nano novel operation preservation reconstruction relating to nervous system spatiotemporal success synaptic function tomography tool voltage

项目摘要

PROJECT SUMMARY/ABSTRACT This project aims to disseminate validated technologies and resources of the National Center for Microscopy and Imaging Research (NCMIR) at UC San Diego to advance the completion of strategic goals of the BRAIN Initiative. The proposed technology integration and dissemination resource will provide the neuroscience community with technical help to obtain and manage large scale data, broadening the access to and incorporation of high throughput multiscale imaging tools and leading-edge analysis strategies in their studies. Richly integrated resources will be offered, including molecular probes, imaging platforms and data analysis tools certain to enable and hasten brain research. The types of research projects we will support, include: 1) investigations requiring the traversal of spatiotemporal scales to reveal new insight and understanding of specific neural populations; 2) investigations which aim to mark and track neuronal processes and/or visualize targeted connectomes of local circuits within large volumes of nervous tissue in multiple animal models; 3) projects which seek to perform nano-histological assessment of cellular and subcellular level alterations associated with learning, physiological state, or disease; and 4) projects performing higher resolution 3D morphometric analysis of subcellular underpinnings of function, with particular emphasis on synaptic function as influenced by subcellular constituents. This new center will leverage an administrative framework and information technology cyberinfrastructure which is already in place and has been refined over many years. In addition to providing a management structure, this framework includes a community outreach, project review, selection, and onboarding process refined and long practiced by the PI (and the assembled team). Additional mechanisms for tool/technology dissemination and training, data management and sharing, and mechanisms for cost-recovery and long-term sustainability will also be leveraged and expanded so as to maximize the reach and impact of our technologies and resources.