Application of mild therapeutic hypothermia for hearing conservation during cochlear implant surgeries
亚低温治疗在人工耳蜗植入手术中听力保护中的应用
基本信息
- 批准号:10327695
- 负责人:
- 金额:$ 40.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-01-11 至 2025-12-31
- 项目状态:未结题
- 来源:
- 关键词:Acoustic StimulationAcousticsAcuteAddressAffectAgeApoptosisAuditoryAuditory Brainstem ResponsesAuditory areaBiologicalBloodBlood VesselsCadaverCaspaseCell CountCell DeathCell SurvivalCell physiologyChildCisplatinClinicalClinical ProtocolsCochleaCochlear ImplantsCochlear implant procedureCustomDataDevelopmentDevicesElectric StimulationElementsEligibility DeterminationEnsureFaceFibrosisFunctional disorderFutureGenderGene ExpressionHair CellsHead and Neck SurgeryHearingHistologicHomeostasisHumanHypoxiaImmunohistochemistryImplantInflammationInflammatoryInjuryInterventionKnowledgeLabyrinthLeadLinkMaintenanceMeasurementMeasuresMechanicsMediatingModelingMolecularMolecular BiologyNeuronsNoiseOperating RoomsOperative Surgical ProceduresOrgan of CortiOutcomeOxidative StressPathway interactionsPatientsPharmacologic SubstancePhysiologic OssificationPhysiologicalPre-Clinical ModelProceduresProtocols documentationPublishingReactionRegimenReperfusion InjuryResearchResidual stateReverse Transcriptase Polymerase Chain ReactionRewarmingSafetySensorineural Hearing LossSensory HairSignal PathwaySpeech PerceptionStria VascularisStructureSynapsesSystemTechniquesTechnologyTemperatureTemporal bone structureTestingTherapeuticTherapeutic InterventionTimeTranslationsTraumaTympanostomyWorkbaseclinical applicationclinical translationcytokinedesigneffective therapyexperimental studyfunctional outcomeshearing impairmenthearing preservationimplantationimprovedindustry partnerischemic injurynatural hypothermianeuroprotectionnext generationotoacoustic emissionototoxicitypre-clinicalpreservationprotective effectpublic health relevancerelating to nervous systemround windowsafety testingspiral ganglionstandard of caretechnological innovationtherapeutically effectivetranscriptome sequencing
项目摘要
Project Summary
More than half a million patients, including children, have benefitted from the remarkable technological
breakthrough that are cochlear implants (CI). An increasing number of patients have some level of residual
hearing at the time of implantation and can benefit from bimodal electro-acoustic devices. Surviving hair cell
activity and as a result a functioning organ of Corti and neural substrate has recently been linked to speech
perception outcomes. However, trauma during implantation leads to inflammation and oxidative stress that can
exacerbate residual hearing loss. Successful translation of therapeutic interventions to limit pathophysiology of
the injury have yet to be achieved. The present work will design and implement applications of localized,
therapeutic hypothermia for protection of hair cells and neural substrate following CI. The specific aims are
motivated by preliminary and published data showing that localized, mild hypothermia delivered to the cochlea
is highly effective and safe, protecting hair cells and synaptic components, protecting the integrity of the
cochlear blood-labyrinth barrier and preserving residual hearing long-term after implantation. Specific aim 1 will
test safety and efficacy of cooling when applied to the cochlea and develop an optimal protocol for improved
long-term functional and physiological outcomes. In specific aim 2 using molecular biology and
immunohistochemistry techniques we will define the neuroprotective mechanisms underlying hypothermia.
Combining the preclinical results with human cadaver temporal bone studies in specific aim 3, we will develop
a device and system for human application. The system will enable delivery of optimized hypothermia therapy
for residual structure and functional protection post-implant. Ensuring the survival of sensitive hair cells and
neural structures in the cochlea are likely to lead to improved speech perception outcomes and will enable
patients to benefit from future technologies and/or therapies. The results from this project can be further
extended to other inner ear-related trauma such as ototoxicity, or noise- and blast-induced trauma.
项目概要
超过 50 万患者(包括儿童)受益于卓越的技术
人工耳蜗(CI)是一项突破。越来越多的患者有一定程度的残留
植入时的听力可以受益于双模电声装置。幸存的毛细胞
活动以及由此产生的柯蒂功能器官和神经基质最近与言语有关
感知结果。然而,植入过程中的创伤会导致炎症和氧化应激
加剧残余听力损失。成功转化治疗干预措施以限制病理生理学
伤害尚未达到。目前的工作将设计和实现本地化的应用程序,
治疗性低温可保护 CI 后的毛细胞和神经基质。具体目标是
初步和已发表的数据显示,局部轻度低温传递至耳蜗
高效、安全,保护毛细胞和突触成分,保护毛细胞的完整性
耳蜗血迷路屏障并在植入后长期保留残余听力。具体目标1将
测试应用于耳蜗的冷却的安全性和有效性,并制定最佳方案以改善
长期功能和生理结果。在具体目标 2 中,利用分子生物学和
通过免疫组织化学技术,我们将定义体温过低的神经保护机制。
将临床前结果与特定目标 3 中的人类尸体颞骨研究相结合,我们将开发
供人类应用的设备和系统。该系统将能够提供优化的低温治疗
用于植入后的残余结构和功能保护。确保敏感毛细胞的存活和
耳蜗的神经结构可能会改善言语感知结果,并使
患者从未来的技术和/或疗法中受益。该项目的成果可进一步
扩展到其他与内耳相关的创伤,例如耳毒性或噪音和爆炸引起的创伤。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Suhrud M. Rajguru其他文献
Radiant energy during infrared neural stimulation at the target structure
红外神经刺激目标结构时的辐射能
- DOI:
- 发表时间:
2013 - 期刊:
- 影响因子:0
- 作者:
C. Richter;Suhrud M. Rajguru;R. Stafford;S. Stock - 通讯作者:
S. Stock
Optical stimulation of the auditory nerve: effects of pulse shape
听觉神经的光刺激:脉冲形状的影响
- DOI:
- 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
R. Banakis;A. I. Matic;Suhrud M. Rajguru;C. Richter - 通讯作者:
C. Richter
Three-Dimensional Biomechanical Model of Benign Paroxysmal Positional Vertigo
良性阵发性位置性眩晕的三维生物力学模型
- DOI:
10.1023/b:abme.0000030259.41143.30 - 发表时间:
2002-12-01 - 期刊:
- 影响因子:3.8
- 作者:
Suhrud M. Rajguru;Marytheresa A. Ifediba;R. Rabbitt - 通讯作者:
R. Rabbitt
Pulsed infrared radiation excites cultured neonatal spiral and vestibular ganglion neurons by modulating mitochondrial calcium cycling.
脉冲红外辐射通过调节线粒体钙循环来刺激培养的新生儿螺旋神经节和前庭神经节神经元。
- DOI:
10.1152/jn.00253.2014 - 发表时间:
2014-09-15 - 期刊:
- 影响因子:2.5
- 作者:
Vicente Lumbreras;E. Bas;C. Gupta;Suhrud M. Rajguru - 通讯作者:
Suhrud M. Rajguru
Inner Ear Therapeutics: An Overview of Middle Ear Delivery
内耳治疗:中耳输送概述
- DOI:
10.3389/fncel.2019.00261 - 发表时间:
2019-06-11 - 期刊:
- 影响因子:5.3
- 作者:
Jaimin Patel;Mikhaylo Szczupak;Suhrud M. Rajguru;C. Balaban;M. Hoffer - 通讯作者:
M. Hoffer
Suhrud M. Rajguru的其他文献
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{{ truncateString('Suhrud M. Rajguru', 18)}}的其他基金
Therapeutic hypothermia to preserve residual hearing in veterans receiving cochlear implantation
低温治疗可保护接受人工耳蜗植入的退伍军人的残余听力
- 批准号:
10314602 - 财政年份:2022
- 资助金额:
$ 40.46万 - 项目类别:
Therapeutic hypothermia to preserve residual hearing in veterans receiving cochlear implantation
低温治疗可保护接受人工耳蜗植入的退伍军人的残余听力
- 批准号:
10616467 - 财政年份:2022
- 资助金额:
$ 40.46万 - 项目类别:
Application of mild therapeutic hypothermia for hearing conservation during cochlear implant surgeries
亚低温治疗在人工耳蜗植入手术中听力保护中的应用
- 批准号:
10540231 - 财政年份:2021
- 资助金额:
$ 40.46万 - 项目类别:
Pulsed infrared excitability of inner ear: molecular mechanisms and therapeutics
内耳脉冲红外兴奋性:分子机制和治疗
- 批准号:
9246496 - 财政年份:2015
- 资助金额:
$ 40.46万 - 项目类别:
Pulsed infrared excitability of inner ear: molecular mechanisms and therapeutics
内耳脉冲红外兴奋性:分子机制和治疗
- 批准号:
9014537 - 财政年份:2015
- 资助金额:
$ 40.46万 - 项目类别:
Pulsed infrared excitability of inner ear: molecular mechanisms and therapeutics
内耳脉冲红外兴奋性:分子机制和治疗
- 批准号:
8887896 - 财政年份:2015
- 资助金额:
$ 40.46万 - 项目类别:
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