Channel structure-based tools for precise interrogation of circuitry and behavior

基于通道结构的工具，用于精确询问电路和行为

• 批准号: 10319554
• 负责人: Karl A. Deisseroth
• 金额: $ 80.22万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-12 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10319554
• 关键词: Affinity; Algae; Amino Acids; Animals; Anxiety; Behavior; Behavioral; Binding; Binding Sites; Brain; Brain region; Cations; Cells; Chlorides; Closure by clamp; Color; Crystallization; Data; Data Set; Detection; Development; Dimensions; Disease; Distant; Electroencephalography; Electrostatics; Elements; Engineering; Environment; Foundations; Fright; Functional Magnetic Resonance Imaging; Funding; Generations; Genomics; Goals; Grant; Image; Integral Membrane Protein; Ion Pumps; Ions; Light; Literature; Mammals; Mental disorders; Methods; Modeling; Molecular; Molecular Structure; Mutation; Nature; Neurosciences; Opsin; Optics; Paper; Pattern; Photons; Polyenes; Positioning Attribute; Positron-Emission Tomography; Property; Proteins; Publishing; Pump; Reporting; Research; Resistance; Resolution; Retina; Science; Side; Structure; Surface; Technology; Testing; Tissues; Triplet Multiple Birth; Variant; Viral Vector; Work; X-Ray Crystallography; anxiety-related behavior; base; design; experimental study; insight; mind control; neural circuit; novel; optogenetics; prevent; redshift; tool; voltage

No abstract provided

没有提供摘要

项目成果

Crystal structure of the natural anion-conducting channelrhodopsin GtACR1.

天然阴离子传导通道视紫红质 GtACR1 的晶体结构。

• 发表时间: 2018-09
• 影响因子: 64.8
• 作者: Kim, Yoon Seok;Kato, Hideaki E;Yamashita, Keitaro;Ito, Shota;Inoue, Keiichi;Ramakrishnan, Charu;Fenno, Lief E;Evans, Kathryn E;Paggi, Joseph M;Dror, Ron O;Kandori, Hideki;Kobilka, Brian K;Deisseroth, Karl
• 通讯作者: Deisseroth, Karl

Leptin regulates the reward value of nutrient.

瘦素调节营养素的奖励值。

• 发表时间: 2011-11-13
• 影响因子: 25
• 作者: Domingos, Ana I;Vaynshteyn, Jake;Voss, Henning U;Ren, Xueying;Gradinaru, Viviana;Zang, Feng;Deisseroth, Karl;de Araujo, Ivan E;Friedman, Jeffrey
• 通讯作者: Friedman, Jeffrey

Structural mechanisms of selectivity and gating in anion channelrhodopsins.

阴离子通道视紫红质的选择性和门控的结构机制。

• 发表时间: 2018-09
• 影响因子: 64.8
• 作者: Kato, Hideaki E;Kim, Yoon Seok;Paggi, Joseph M;Evans, Kathryn E;Allen, William E;Richardson, Claire;Inoue, Keiichi;Ito, Shota;Ramakrishnan, Charu;Fenno, Lief E;Yamashita, Keitaro;Hilger, Daniel;Lee, Soo Yeun;Berndt, Andre;Shen, Kang;Kandori
• 通讯作者: Kandori

Interacting neural ensembles in orbitofrontal cortex for social and feeding behaviour.

眶额皮质中相互作用的神经元群用于社交和进食行为。

• 发表时间: 2019-01
• 影响因子: 64.8
• 作者: Jennings, Joshua H;Kim, Christina K;Marshel, James H;Raffiee, Misha;Ye, Li;Quirin, Sean;Pak, Sally;Ramakrishnan, Charu;Deisseroth, Karl
• 通讯作者: Deisseroth, Karl

Supplementary Materials for Cortical layer – specific critical dynamics triggering perception

皮质层的补充材料 — 触发感知的特定关键动态

• DOI: 10.1038/s41598-019-53344-6
• 发表时间: 2024-09-14
• 期刊: Scientific Reports
• 影响因子: 4.6
• 作者: James H. Marshel;Y. Kim;Timothy A. Machado;S. Quirin;Br;on;on;Benson;Jonathan Kadmon;Cephra Raja;A. Chibukhchyan;C. Ramakrishnan;Masatoshi Inoue;J. Shane;D. McKnight;Susumu Yoshizawa;Hideaki E. Kato;S. Ganguli;K. Deisseroth
• 通讯作者: K. Deisseroth