NINDS Stroke Trials Network - Regional Coordinating Center

NINDS 中风试验网络 - 区域协调中心

• 批准号: 10306038
• 负责人: KAMAKSHI LAKSHMINARAYAN
• 金额: $ 30.8万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10306038
• 关键词: Address; Affect; Age; Award; Caring; Cessation of life; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Development; Disease; Education; Emergency Care; Emergency Medicine; Emergency research; Environment; Fostering; Funding; Goals; Hospitals; Incubators; Individual; Infrastructure; Intervention; Medicine; Minnesota; Mission; Multi-Institutional Clinical Trial; Multicenter Trials; National Heart, Lung, and Blood Institute; National Institute of Neurological Disorders and Stroke; Neurological emergencies; Patient Recruitments; Patients; Population; Prevention; Public Health; Recovery; Research; Research Personnel; Research Training; Role; Science; Site; Stroke; Stroke prevention; StrokeNet clinical trials; Time; Training; United States National Institutes of Health; Universities; Work; career; career development; design; disability; experience; follow-up; human subject protection; improved; innovation; investigator-initiated trial; medical specialties; member; mortality; nervous system disorder; programs; recruit; research and development; stroke clinical trials; stroke therapy; stroke trials; trend

Stroke is a common neurological disease and is a growing major public health problem. Although mortality is declining, it remains the number four cause of none-accidental death in the U.S. It is still the leading cause of major disability, and as the population ages and becomes more diverse, the number of affected individuals is expected to significantly grow. The mission of NINDS is to reduce the burden of neurological disease and stroke. Multicenter clinical trials are key in advancing the science and practice of stroke treatment. National Institutes of Health funded clinical trials have often suffered from long start up time and delays in completing the research. Disease specific research consortiums are part of a national trend to improve these deficiencies by providing a common infrastructure that will facilitate the design, startup, and conduct of multicenter trials, streamlining site selection, research team organization, and human subject protection. It will minimize the need to reorganize the research team for every new trial. Enhanced collaboration will result from such a network, and will function as an incubator for new research and provide a rich environment for research training. The StrokeNET network was created in 2013 to achieve those goals. The University of Minnesota (UMN) and its stroke program are uniquely qualified to serve a Regional Coordinating Center. It has access to a broad set of academic researchers relevant for this field, with depth in various domains of clinical research. It has extensive experience in implementing research networks, proven as a current member in StrokeNet, and collaboration with the University of Minnesota hub of SIREN (Strategies to Innovate EmeRgENcy Care Clinical Trials Network, the NINDS/NHLBI emergency medicine research network), as well as the previous experience and relationships built by being part of the two previous funding cycles of the NINDS Neurological Emergency Research Network (NETT). The leaders for this application are experienced in stroke clinical research, managing research networks, and are experts in the subject matter. The various specialties needed to collaborate for successful implementation of the trials are already aligned administratively in collaborative units beyond traditional departments. Within the previous cycle of StrokeNET, our regional center contributed significantly to the network, participating in seven clinical trials with the total number of subjects recruited within the top tier of all RCC’s, a very high rate of patient retention, subject follow-up and document completion. We have actively engaged with 13 hospitals regionally that have recruited patients into network trials. We have brought two proposals for investigator initiated trials and served on several key committees within the network. We have trained four StrokeNet fellows and a team member served on the education committee. Overall, the current stroke program at the University of Minnesota is an excellent candidate to renew its role as an NIH StrokeNet Regional Coordinating Center.

中风是一种常见的神经系统疾病，也是一个日益严重的公共卫生问题，尽管死亡率很高。 尽管有所下降，但它仍然是美国非意外死亡的第四大原因。 严重残疾，并且随着人口老龄化和变得更加多样化，受影响的人数 NINDS 的使命是减轻神经系统疾病和疾病的负担。 多中心临床试验是推进中风治疗科学和实践的关键。 卫生研究院资助的临床试验常常面临启动时间长和完成延迟的问题 特定疾病研究联盟是改善这些缺陷的国家趋势的一部分。 通过提供一个共同的基础设施来促进多中心试验的设计、启动和进行， 简化地点选择、研究团队组织和人类受试者保护这将最大限度地减少需求。 这样的网络将加强每一项新试验的研究团队， 并将作为新研究的孵化器，并为研究培训提供丰富的环境。 StrokeNET 网络于 2013 年创建，旨在实现这些目标。 中风项目具有独特的资格为区域协调中心提供服务，它可以接触到广泛的资源。 与该领域相关的学术研究人员，在临床研究的各个领域具有广泛的深度。 作为 StrokeNet 的当前成员，拥有实施研究网络的经验以及协作 与明尼苏达大学 SIREN 中心合作（创新紧急护理临床试验的策略） 网络（NINDS/NHLBI 急诊医学研究网络），以及以前的经验和 通过参与 NINDS 神经紧急情况的前两个资助周期建立的关系 研究网络 (NETT)。该应用程序的领导者在中风临床研究方面经验丰富， 管理研究网络，并且是该主题所需的各种专业的专家。 合作实施试验的成功已经在协作单位中进行了行政协调 在 StrokeNET 的上一个周期中，我们的区域中心做出了超越传统部门的贡献。 对网络有显着影响，参与七项临床试验，招募受试者总数 在所有 RCC 中名列前茅，患者保留率、受试者随访率和记录率非常高 我们已积极与该地区 13 家已招募患者加入网络的医院接洽。 我们为研究者发起的试验提出了两项​​提案，并在几个关键委员会任职。 我们在网络内培训了四名 StrokeNet 研究员和一名负责教育的团队成员。 总体而言，明尼苏达大学目前的卒中项目是一个很好的候选者。 更新其作为 NIH StrokeNet 区域协调中心的角色。