Mentoring in Endocrine and Cardiometabolic Abnormalities in Cancer and Aging

癌症和衰老中内分泌和心脏代谢异常的指导

• 批准号: 10300180
• 负责人: Shehzad Basaria
• 金额: $ 18.48万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10300180
• 关键词: Address; Age; Aging; American; Androgens; Area; Award; Baltimore; Benefits and Risks; Boston; Cancer Burden; Capsicum; Cardiometabolic Disease; Caring; Clinical; Clinical Research; Clinical Trials; Colorectal Cancer; Data; Deposition; Deterioration; Diabetes Mellitus; Diagnosis; Disease; Endocrine; Endocrine System Diseases; Endocrinologist; Endocrinology; Enrollment; Environment; Erythropoiesis; Faculty; Fatigue; Fatty Liver; Fatty acid glycerol esters; Fostering; Functional disorder; Funding; General Population; Geriatrics; Goals; Grant; Health; High Prevalence; Hospitals; Hypogonadism; Incidence; Infiltration; Inflammation; Infrastructure; Institution; Insulin Resistance; International; Investigation; K-Series Research Career Programs; Lead; Longitudinal Studies; Lower Extremity; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Measures; Medical; Medicine; Mentors; Mentorship; Metabolic; Metabolic syndrome; Metabolism; Metastatic Prostate Cancer; Mid-Career Clinical Scientist Award (K24); Morbidity - disease rate; Muscle; Oncology; Participant; Physical Function; Physical Performance; Prostate; Research; Research Institute; Research Personnel; Research Support; Resources; Role; Science; Series; Skeletal Muscle; Testosterone; Thinness; Time; Tissues; Training; Translational Research; United States; United States National Institutes of Health; Upper Extremity; Urology; Woman; Work; age related; androgen deprivation therapy; cardiometabolic risk; cardiometabolism; career; clinical center; clinical investigation; cytokine; disabling symptom; frailty; improved; interest; medical schools; medical specialties; men; mid-career faculty; multidisciplinary; muscle form; muscle strength; next generation; novel; older men; patient oriented research; programs; prospective; prostate cancer survivors; reduced muscle strength; side effect; skills

PROJECT SUMMARY Shehzad Basaria, MD, an Associate Professor of Medicine and Endocrinology in the Division of Endocrinology, Diabetes, & Metabolism at Brigham and Women's Hospital, Harvard Medical School, submits this application for a K24 Mid-Career Development award to provide protected time to mentor trainees in Patient-Oriented Research (POR) in Endocrine aspects of Gero-Oncology. Dr. Basaria is one of the few endocrinologists worldwide specializing in endocrine and cardio-metabolic disorders in older men with cancer and androgen deficiency. He will pursue additional training to hone his mentoring skills in order to build on his established record of mentorship and foster the research careers of early investigators. Candidate: Dr. Basaria is a highly productive clinical researcher in the field of Endocrinology, Aging and Cancer. Since 2003, he has been continuously NIH-funded to investigate: i) endocrine and cardio-metabolic complications of androgen deprivation therapy (ADT) in men with prostate cancer (PCa), ii) benefits and risks of androgen replacement in older men, and iii) endocrinology of aging. He has conducted his investigations using NIH-supported infrastructure, including RO1s and R21 grants, data from the Baltimore Longitudinal Study of Aging (BLSA), the InChianti Study, and the Boston Pepper Center for Function-Promoting Therapies. With his uncommon skill set and strong POR program in Endocrinology and Gero-Oncology, he has been a sought-after collaborator and mentor at Brigham/Harvard and at national and international institutions. Mentoring Plan/Environment: This application will leverage the extensive training resources at Brigham/Harvard, including the Center for Clinical Investigation, the Brigham Research Institute for Clinical and Translational Research, and T32 training grants in a variety of specialties. It will also draw on the unparalleled resources of the Boston Pepper Center and other funded studies to serve as a platform for POR trainees at multiple levels. Research Plan: The novel research supported by this K24 award will make significant contributions to the 1A) The impact of ADT-induced profound hypogonadism and the resulting decline in muscle mass on physical function, 1B) The impact of ADT on fat infiltration of skeletal muscles and the association of this deterioration in muscle quality on physical function, and 2) The mechanisms by which testosterone replacement improves Cancer- Related Fatigue in older men with cancer. understanding of the impact of androgen deficiency in older men with cancer in three major areas: These novel aims will build on the ongoing work in Dr. Basaria's current R01s, explore new hypotheses, and expand opportunities for trainees.

项目概要 Shehzad Basaria 医学博士，内分泌科医学和内分泌学副教授， 哈佛医学院布莱根妇女医院的糖尿病和新陈代谢提交了此申请 获得 K24 职业中期发展奖，为以患者为导向的学员提供受保护的时间指导 老年肿瘤学内分泌方面的研究（POR）。 Basaria 博士是少数内分泌学家之一 全球范围内专门研究患有癌症和雄激素的老年男性的内分泌和心脏代谢疾病 不足。他将接受额外的培训来磨练他的指导技能，以便在他既定的基础上再接再厉。 指导记录并促进早期研究人员的研究生涯。 候选人：Basaria 博士是内分泌学、衰老学和内分泌学领域一位高产的临床研究员。 癌症。自 2003 年以来，他持续获得 NIH 资助，研究：i) 内分泌和心脏代谢 前列腺癌 (PCa) 男性雄激素剥夺疗法 (ADT) 的并发症，ii) 益处和风险 老年男性雄激素替代的研究，以及 iii) 衰老内分泌学。他已经进行了调查 使用 NIH 支持的基础设施，包括 RO1 和 R21 拨款、来自巴尔的摩纵向的数据 衰老研究 (BLSA)、InChianti 研究和波士顿胡椒功能促进治疗中心。 凭借他在内分泌学和老年肿瘤学方面非凡的技能和强大的 POR 计划，他一直是 在布里格姆/哈佛大学以及国家和国际机构中广受欢迎的合作者和导师。 指导计划/环境：此应用程序将利用以下位置的广泛培训资源： 布里格姆/哈佛大学，包括临床研究中心、布里格姆临床和临床研究所 各种专业的转化研究和 T32 培训补助金。它还将借鉴无与伦比的 波士顿胡椒中心的资源和其他资助的研究为 POR 学员提供了一个平台 多个级别。 研究计划：本次K24奖支持的新颖研究将为该领域做出重大贡献 1A） ADT 引起的严重性腺功能减退症以及由此导致的肌肉质量下降对身体功能的影响， 1B) ADT 对骨骼肌脂肪浸润的影响以及这种肌肉退化的关联 身体机能质量，以及 2) 睾酮替代疗法改善癌症的机制- 患有癌症的老年男性的相关疲劳。 了解雄激素缺乏对患有癌症的老年男性在三个主要方面的影响： 这些新颖的目标将建立在 Basaria 博士正在进行的工作的基础上 现有的 R01，探索新的假设，并为学员扩大机会。