Center for Aging and Policy Studies - Alzheimer's Disease Research Supplement

老龄化与政策研究中心 - 阿尔茨海默病研究增刊

• 批准号: 10286938
• 负责人: Jennifer Karas Montez
• 金额: $ 22.17万
• 依托单位: SYRACUSE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10286938
• 关键词: Address; Administrative Supplement; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Behavioral; Biological Markers; Buffers; Cause of Death; Child; Cognitive aging; Consumption; Dementia; Demography; Development; Diagnosis; Down Syndrome; Economics; Elderly; Family; Family member; Fostering; Funding; Grant; Health; Impaired cognition; Incidence; Income; Individual; Interdisciplinary Study; London; Measures; Parents; Pathway interactions; Personal Satisfaction; Pilot Projects; Policies; Population; Prevalence; Program Development; Reporting; Request for Applications; Research; Research Support; Research Training; Resources; Risk; Risk Factors; Role; Rural; Scientist; Shock; Social Sciences; Surveys; Testing; Universities; Yang; arterial stiffness; base; burden of illness; cognitive change; data resource; disability; human capital; innovation; intergenerational; knowledge base; middle age; modifiable risk; mortality; novel; population based; programs; social; urban area

The proposed research consists of five distinct Pilot Projects, each of which will be carried out as part of the Center for Aging and Policy Studies (CAPS)’s Program Development (Pilot) Core (Core B). All five are population-based social science studies that address one or more of NIA’s announced priorities in the area of Alzheimer’s disease and related dementias (ADRD) research. Two of the proposed tasks represent a broadening of the analyses conducted in existing Pilot Projects. (1) Consequences of Disabilities in Late Middle Age for Consumption Well- Being, will examine the consequences of disability in late middle age for economic well-being using consumption-based measures instead of the usual income-based measures. (2) Health Shocks and Changes in Spatial Proximity between Parents and Children will study how changes in spatial proximity of family members evolves relative to changes in health, such as an AD diagnosis. The remaining three projects represent new, ADRD-focused studies that contribute to CAPS’s Specific Aims. (3) Estimated Arterial Stiffness as a Predictor of Cognitive Decline and Dementia in Middle-Aged and Older Adults will use a novel survey-based measure of arterial stiffness to predict cognitive decline and the transition to a dementia diagnosis. (4) Comparing Alzheimer’s Related Mortality Among People with and without Down Syndrome examines differences between those with and without Down syndrome with respect to ADRD prevalence and in reported cause of death. (5) Living alone and risk for the development of Alzheimer’s Disease and related dementias: When does solitary living matter and why will investigate the role of living alone as a risk factor for ADRD onset, as well as the presence of factors that buffer this risk. Together, these projects will produce important new findings in a number of priority areas, including the proposed research will address both the prevalence and the incidence of cognitive decline and dementia; will inform the knowledge base with respect to trajectories of cognitive decline and aging; and will provide new findings on the consequences for individuals and their families of prevalent ADRD, adding to our knowledge about the population-level burden of illness. Additionally, one of the proposed projects will develop and apply an innovative approach to using biomarkers as an early sign of dementia, which promises to add to our knowledge regarding causal pathways to cognitive decline and ADRD, and to suggest possible malleable mechanistic targets on behavioral and social pathways to ADRD.

拟议的研究由五个不同的试点项目组成，每个项目都将作为 老龄化与政策研究中心 (CAPS) 项目开发（试点）核心的一部分 B) 所有五项都是基于人口的社会科学研究，涉及 NIA 的一项或多项问题。 宣布了阿尔茨海默氏病和相关痴呆症（ADRD）领域的优先事项 其中两项拟议任务代表了现有分析的扩大。 试点项目。 (1) 中年晚期残疾对消费健康的影响 存在，将研究中年晚期残疾对经济福祉的影响 (2) 健康 父母和孩子之间空间接近度的冲击和变化将研究如何 家庭成员空间距离的变化与健康状况的变化相关，例如 其余三个项目代表了以 ADRD 为重点的新研究，对 AD 诊断做出了贡献。 CAPS 的具体目标 (3) 估计动脉僵硬度作为认知下降的预测因子。 中年和老年人的痴呆症将使用一种新颖的基于调查的测量方法 动脉僵硬度可预测认知能力下降和向痴呆症诊断的转变 (4)。 比较患有和不患有唐氏综合症的人与阿尔茨海默病相关的死亡率 检查患有和不患有唐氏综合症的人在 ADRD 方面的差异 (5) 独居及发展风险 阿尔茨海默病和相关痴呆症：独居生活何时重要以及为什么会重要 调查独居作为 ADRD 发病危险因素的作用，以及是否存在 这些项目共同将产生重要的新发现。 一些优先领域，包括拟议的研究，将解决患病率和 认知能力下降和痴呆症的发生率将为知识库提供信息； 认知衰退和衰老的轨迹；并将提供关于其后果的新发现； 对于患有 ADRD 的个人及其家庭，增加了我们对 ADRD 的了解 此外，拟议项目之一将制定和实施。 采用创新方法使用生物标志物作为痴呆症的早期迹象，这有望 增加我们对认知衰退和 ADRD 因果关系的了解，并 提出了 ADRD 行为和社会途径上可能的可塑性机制目标。