Neuroscience-based Interventions for Cancer Risk Behavior Change

基于神经科学的癌症风险行为改变干预措施

• 批准号: 10226314
• 负责人: CARYN LERMAN
• 金额: $ 73.41万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10226314
• 关键词: Academy; Address; Award; Behavior; Behavioral; Behavioral Sciences; Body Weight decreased; Brain; Cancer Center; Cancer Intervention; Cessation of life; Cognitive; Complement; Data; Decision Making; Eating; Funding; Genetic; Goals; Grant; Habits; Human Genome; Impaired cognition; Individual; Institute of Medicine (U.S.); Intervention; Knowledge; Laboratories; Lead; Maintenance; Malignant Neoplasms; National Institute of Drug Abuse; Nature; Neurosciences; Nicotine; Obesity; Peer Review; Pharmacology; Phase; Phase III Clinical Trials; Prefrontal Cortex; Process; Psychiatry; Publications; Randomized Controlled Clinical Trials; Research; Resistance; Risk; Risk Behaviors; Risk Factors; Role; Self-control as a personality trait; Services; Short-Term Memory; Smoking Cessation Intervention; Societies; Tobacco; Tobacco use; Translating; Work; base; behavior change; cancer prevention; cancer risk; cigarette smoking; cognitive control; cognitive function; cognitive training; cost; efficacy evaluation; experience; experimental study; innovation; member; novel; professor; public health relevance; self reported behavior

 DESCRIPTION (provided by applicant): Tobacco use and obesity account for over 45% of preventable cancer deaths. Yet, these cancer risk behaviors are resistant to long-term change, despite widespread knowledge of the risks. Even with the best treatments available, most people revert to their former practices of cigarette smoking or eating. While behavior change interventions may address the habitual nature of these behaviors, they do not tackle the disruptive brain processes that undermine sustainable behavior change. Tobacco use and obesity are associated with cognitive impairments and altered brain functions that can interfere with the maintenance of goal-directed behaviors. More specifically, work in my laboratory points to the central role of alterations in working memory-related activation in the dorsolateral prefrontal cortices (DLPFC). DLPFC is at the core of the brain's cognitive control network, which supports planning, decision- making, and cognitive (self) control. Importantly, our pilot data show that DLPFC function can be safely restored using a novel and low-cost neuroscience-based intervention. Thus, the bold premise of this application is that it is possible to enhance th brain's capacity to over-ride behavioral habits that contribute to obesity and cigarette smoking, and ultimately to cancer. Broad Plan: Extending our pilot work, the proposed 7-year research plan begins with a Proof of Mechanism experiment to validate the effects of DLPFC-targeted transcranial direct current brain stimulation (tDCS) with cognitive training. Progressing to the Proof of Principle stage, experiments will identify the optimal type of cognitive training to complement tDCS and the optimal number of treatment sessions, with a focus on intermediate endpoints (e.g., cognitive function, risky decision-making, self-reported behaviors). In the final stage of the research plan, Phase II randomized controlled clinical trials will evaluate the efficacy of the optimized neuroscience-based interventions for individuals seeking treatment for smoking cessation (Study 1) and weight loss (Study 2). The deliverables are efficacious neuroscience-based interventions to be validated in Phase III clinical trials and translated to practice for behavioral cancer prevention. Qualifications: As the Mary W. Calkins Professor of Psychiatry and Deputy Director of the Abramson Cancer Center at UPenn, I have decades of experience conducting innovative behavioral science research that bridges the fields of neuroscience, pharmacology, and genetics. I have been continuously funded by NCI since 1989, with grants totaling ~$67 million in total costs (including an NCI Provocative Question Award). With >345 peer-reviewed publications, my Google Scholar H-INDEX is 90. My service includes membership on the NCI Board of Scientific Advisors, National Human Genome Research Advisory Council, and the National Institutes on Drug Abuse Advisory Council. I am a past President of the Society for Research on Nicotine and Tobacco, and an Elected Member of the Institute of Medicine of the National Academies.

 描述（由申请人提供）：吸烟和肥胖占可预防癌症死亡的 45% 以上。然而，尽管人们普遍了解这些风险，但大多数癌症风险行为都难以长期改变。人们恢复了以前吸烟或饮食的习惯，虽然行为改变干预措施可能会解决这些行为的习惯性问题，但它们并不能解决破坏可持续行为改变的破坏性大脑过程，而这些过程与认知障碍和肥胖有关。更具体地说，我实验室的工作表明，背外侧前额皮质（DLPFC）中与工作记忆相关的激活的改变起着核心作用。重要的是，我们的试验数据表明，使用一种新颖且低成本的基于神经科学的干预措施可以安全地恢复 DLPFC 功能。该应用的前提是，有可能增强大脑克服导致肥胖和吸烟并最终导致癌症的行为习惯的能力。 广泛计划：扩展我们的试点工作，拟议的七年研究计划始于。机制验证实验，用于验证 DLPFC 靶向经颅直流脑刺激 (tDCS) 与认知训练的效果。进入原理验证阶段，实验将确定补充的最佳认知训练类型。 tDCS 和最佳治疗次数，重点关注中间终点（例如认知功能、风险决策、自我报告行为）。在研究计划的最后阶段，II 期随机对照临床试验将评估治疗效果。针对寻求戒烟（研究 1）和减肥（研究 2）治疗的个体的优化的基于神经科学的干预措施的功效这些成果是基于神经科学的有效干预措施，将在 III 期临床中进行验证。资格：作为宾夕法尼亚大学艾布拉姆森癌症中心的 Mary W. Calkins 精神病学教授和副主任，我拥有数十年在神经科学和药理学领域进行创新行为科学研究的经验。自 1989 年以来，我一直受到 NCI 的资助，资助总额约为 6700 万美元（包括 NCI 挑衅性问题奖，经同行评审超过 345 项）。我的 Google Scholar H-INDEX 为 90。我的服务包括 NCI 科学顾问委员会、国家人类基因组研究咨询委员会和国家药物滥用研究所咨询委员会的成员资格。我是研究学会的前任主席。研究尼古丁和烟草问题，并当选为美国国家科学院医学研究所成员。

项目成果

Impact of early nausea on varenicline adherence and smoking cessation.

早期恶心对伐尼克兰依从性和戒烟的影响。

• 发表时间: 2020
• 作者: Peng, Annie R;Swardfager, Walter;Benowitz, Neal L;Ahluwalia, Jasjit S;Lerman, Caryn;Nollen, Nicole L;Tyndale, Rachel F
• 通讯作者: Tyndale, Rachel F

Flexible Utility Function Approximation via Cubic Bezier Splines.

通过三次贝塞尔样条线进行灵活的效用函数逼近。

• 发表时间: 2020
• 影响因子: 3
• 作者: Lee, Sangil;Glaze, Chris M;Bradlow, Eric T;Kable, Joseph W
• 通讯作者: Kable, Joseph W

Transcranial Direct Current Brain Stimulation Increases Ability to Resist Smoking.

经颅直流脑刺激可提高抵制吸烟的能力。

• 发表时间: 2016
• 影响因子: 7.7
• 作者: Falcone, Mary;Bernardo, Leah;Ashare, Rebecca L;Hamilton, Roy;Faseyitan, Olufunsho;McKee, Sherry A;Loughead, James;Lerman, Caryn
• 通讯作者: Lerman, Caryn

Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans.

对非洲裔和欧洲裔美国人按性别分层的尼古丁代谢生物标志物遗传学分析。

• 发表时间: 2021
• 影响因子: 4.6
• 作者: Chenoweth, Meghan J;Cox, Lisa Sanderson;Nollen, Nikki L;Ahluwalia, Jasjit S;Benowitz, Neal L;Lerman, Caryn;Knight, Jo;Tyndale, Rachel F
• 通讯作者: Tyndale, Rachel F

An fMRI-based brain marker predicts individual differences in delay discounting

基于功能磁共振成像的大脑标记可以预测延迟贴现的个体差异

• DOI: 10.1016/0009-2509(57)85010-6
• 发表时间: 2024-09-13
• 期刊: Chemical Engineering Science
• 影响因子: 4.7
• 作者: A.;Simonetti;M. Boerth;A. Koehlmoos;S. Winkler;L. Bernardo;A. M. Burke;M. K. Caulfield;N. Cooper;G. Donnay;M. Falcone;J. Jørgensen;R. Kazinka;J. Luery;M. McConnell;R. Miglin;D. Mukherjee;T. Parthasarathi;S. Price;M. Schlussel;R. Sharp;H. J. Sohn;D. Spence;K. Terilli
• 通讯作者: K. Terilli