Biospecimen Core

生物样本核心

基本信息

批准号：
10224122
负责人：
Craig Michael Horbinski
金额：
$ 29.48万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-17 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10224122
关键词：
Autopsy Bioinformatics Biological Assay Biological Markers Biological Specimen Banks Biometry Blood Blood specimen Brain Neoplasms Caring Cell Line Cells Cerebrospinal Fluid Clinical Clinical Research Collection Consent Consultations Cryopreservation DNA Data Databases Development Diagnostic Engraftment Ensure Equipment and supply inventories Evaluation Freezing Funding Genes Glioma Histologic Hospitals Human Resources Immunocompromised Host Individual Institution Laboratory Research Lymphocyte Malignant Neoplasms Malignant neoplasm of brain Microscopy Modeling Molecular Molecular Profiling Mus Mutation Normal tissue morphology Operating Rooms Operative Surgical Procedures Paraffin Embedding Pathologic Patients Pattern Plasma Procedures Promega Protocols documentation Quality Control RNA analysis Recurrence Research Research Personnel Research Support Resistance Resources Sampling Secure Services Short Tandem Repeat Source Specimen Supervision Testing Therapeutic Time Tissue Sample Tissues Translations Tumor Tissue base biobank cancer stem cell cell free DNA clinical translation experience follow-up improved innovation interest light microscopy neoplastic cell next generation sequencing patient derived xenograft model repository stem cell model therapy outcome transcriptome sequencing transcriptomics translational approach tumor tumor registry

项目摘要

BIOSPECIMEN CORE: SUMMARY The Biospecimen Core is a vital resource that supports all brain tumor research at Northwestern, and is especially important in seeing that all projects experience clinical translation within the period of SPORE funding. Regular interactions with the Biostatistics & Bioinformatics Core and Administrative Core will ensure that each project achieves its objectives, and has positive impact on the care of brain tumor patients. The Biospecimen Core will have extensive interactions with all projects and cores by acting as the central repository of patient tissues and renewable tumor resources, by providing the highest quality of tissue analytical services, and by providing neuropathological consultation. The Director of the Core, Dr. Horbinski, as well as the Co-Director, Dr. Daniel Brat, will supervise quality control testing of banked specimens, and will perform all microscopy-based analyses of patient tissues and tumor models for each SPORE project. Biospecimen Core activities will be performed to accomplish the following aims: Aim 1: Provide Northwestern brain tumor researchers with annotated biospecimens from brain tumor patients. Aim 2: Subject all biospecimens to rigorous quality control. Aim 3: Propagate, bank, and characterize surgical specimen derivatives, including PDX and cancer stem cell (CSC) models, to meet ongoing needs for renewable tumor cell sources. Aim 4: Support SPORE projects with biospecimens and neuropathologic analyses.

生物样本核心：总结生物样本核心是支持西北大学所有脑肿瘤研究的重要资源，并且尤其重要的是，所有项目都在 SPORE 期间经历了临床转化资金。与生物统计和生物信息学核心以及行政核心的定期互动将确保每个项目均实现其目标，并对脑肿瘤患者的护理产生积极影响。生物样本核心将作为中心与所有项目和核心进行广泛的互动通过提供最高质量的组织来存储患者组织和可再生肿瘤资源分析服务，并提供神经病理学咨询。核心主任 Horbinski 博士以及联合主任 Daniel Brat 博士将监督储存样本的质量控制测试，并将对每个 SPORE 项目的患者组织和肿瘤模型进行所有基于显微镜的分析。将开展生物样本核心活动以实现以下目标：目标 1：为西北脑肿瘤研究人员提供带注释的脑肿瘤生物样本患者。目标 2：对所有生物样本进行严格的质量控制。目标 3：传播、储存和表征手术标本衍生物，包括 PDX 和癌症干细胞（CSC）模型，以满足对可再生肿瘤细胞来源的持续需求。目标 4：通过生物样本和神经病理学分析支持 SPORE 项目。