NONLINEARITY TO DISSECT THE VISUAL SYSTEM

非线性剖析视觉系统

• 批准号: 2163918
• 负责人: ANDREW STOCKMAN
• 金额: $ 9.47万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2163918
• 关键词: NONLINEARITY; DISSECT; VISUAL; SYSTEM; NONLINEARITY; DISSECT; VISUAL; SYSTEM

A series of experiments is proposed that will use various non-linearities revealed by time-varying visual stimuli to analyze the human visual pathway. When an input signal passes through a non-linear site, new signal components are produced that were not present at its input. By carefully manipulating the visual stimuli that provide the input signal to the non-linearity, it is possible to distinguish the temporal properties of the visual pathways before and after each non-linear site. Three non-linearities will be studied. Each causes a burst of flicker to be perceived differently from a steady light of the same time-averaged intensity and chromaticity. The first, a compressive non-linearity, causes S-cone detected flicker to change in color; the second, also a compressive non-linearity, causes bursts of M- of L-cone detected flicker to change in color and saturation; and the third, an expansive non- linearity, causes bursts of M- or L-cone detected flicker to increase in apparent brightness. The primary aim of the proposed experiments is to use each non-linearity to dissect the early visual pathway. In some experiments, the non-linearity will be used as a recording electrode -- to measure the temporal frequency response of the visual system before the non-linearity; and in others it will be used as a stimulating electrode -- to measure the temporal frequency response of the visual system after the non-linearity. Preliminary evidence suggests that the temporal frequency response after each compressive non-linearity is characteristic of a chromatic pathway, while the response before each compressive non-linearity may more closely reflect the temporal frequency response of the receptors that the results of conventional temporal sensitivity measurements. It is proposed that the expansive non- linearity that affects M- and L-cone flicker is in a separate luminance pathway. The results of the proposed experiments will provide new insights into the postreceptoral organization of the visual system. Each non-linear site can provide a landmark at which psychophysical and physiological results can be compared. In the long-term, these experiments also may have important clinical implications, since it will be possible to use each non-linear site to localize and damage or deterioration that results from degenerative disease.

提出了一系列实验，该实验将使用各种非线性 随时间变化的视觉刺激揭示了人类视觉 路径。 当输入信号通过非线性位点时， 产生的信号成分在其输入中不存在。 经过 仔细操纵提供输入信号的视觉刺激 对于非线性，可以区分时间 每个非线性位点之前和之后的视觉途径的性质。 将研究三个非线性。 每个都会引起闪烁 与相同时间平均的稳定光线不同的看法不同 强度和色彩。 首先，一种压缩的非线性， 导致S-Cone检测到的闪烁变化；第二，也是 压缩非线性，导致L-CONE检测到的M-爆发 改变颜色和饱和；第三，一个广阔的非 - 线性，导致M-或L-CONE检测到的闪烁突发增加 明显的亮度。 拟议实验的主要目的是 使用每种非线性来剖定早期的视觉途径。 在某些人中 实验，非线性将用作记录电极 - 测量视觉系统的时间频率响应 非线性；在其他情况下，它将用作刺激 电极 - 测量视觉的时间频率响应 非线性之后的系统。 初步证据表明 每种压缩非线性后的时间频率响应是 彩色途径的特征，而每个响应 压缩非线性可能会更紧密地反映时间频率 受体的反应是传统时间的结果 灵敏度测量。 有人提出，宽敞的非 - 影响M-和L-Cone闪烁的线性性在单独的亮度中 路径。 拟议的实验的结果将提供新的 洞悉视觉系统的后受感染组织。 每个 非线性网站可以提供心理物理和心理物理和 可以比较生理结果。 从长远来看，这些 实验也可能具有重要的临床意义，因为它将 有可能使用每个非线性站点进行本地化和损坏或 由退化性疾病导致的恶化。