Air Pollution, Stress and Asthma Morbidity Risk: Role of Biological and Geospatial Markers

空气污染、压力和哮喘发病风险：生物和地理空间标记的作用

基本信息

批准号：
10216007
负责人：
Marissa Hauptman
金额：
$ 19.71万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-05-01 至 2026-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10216007
关键词：
Active Learning Address Adverse effects Air Pollutants Air Pollution Area Aromatic Polycyclic Hydrocarbons Asthma Bioinformatics Biological Biological Markers Biometry Boston Caring Characteristics Child Childhood Childhood Asthma Chronic Chronic Disease Clinical Clinical Medicine Clinical Research Communities Computerized Medical Record Dangerousness Data Data Sources Development Plans Disease Electronic Health Record Environment Environmental Air Pollutants Environmental Epidemiology Environmental Exposure Environmental Health Environmental Medicine Environmental Pollutants Environmental Risk Factor Epidemiology Exposure to Family Fellowship Foundations Funding Future Goals Guidelines Health Health Personnel Health Professional Health Services Research Housing Immunologics Individual Institutional Review Boards International Intervention Joints Knowledge Lead Measures Medical Mentors Mentorship Methodology Morbidity - disease rate National Institute of Environmental Health Sciences Outcomes Research Patients Pediatric Hospitals Pediatrics Physicians Play Pollution Population Positioning Attribute Predisposition Public Health Schools Reporting Research Research Personnel Research Project Grants Residencies Resources Risk Risk Factors Role Schools Science Scientist Stress Subgroup System Testing Therapeutic Therapeutic Intervention Time Training Translational Research United States National Institutes of Health Work asthma model asthmatic patient biomedical informatics career career development catalyst clinical care clinical center clinical decision support clinical decision-making clinical implementation clinical risk cohort data repository environmental intervention environmental stressor experience health disparity high risk improved inner city innovation instructor medical schools meetings novel novel therapeutics patient population pediatric patients pediatrician pollutant predictive modeling preventive intervention programs skills social social determinants social stressor tool traffic-related air pollution urinary

项目摘要

PROJECT SUMMARY / ABSTRACT Candidate: Dr. Marissa Hauptman is an Instructor of Pediatrics at Harvard Medical School (HMS), a pediatrician and environmental medical toxicologist, and Assistant Director of the Pediatric Environmental Health Center at Boston Children’s Hospital (BCH). At BCH, she completed her pediatrics residency and a joint pediatric environmental medicine and health services research fellowship. Building on her early work, her proposed career development plan focuses on 2 areas of career development—geospatial and biomarker environmental exposure science, clinical biomedical informatics—that will add to her research toolkit, increase the rigor of her work, and enhance her ability to develop, evaluate, and integrate environmental exposure science and epidemiology into clinical medicine. She will gain these skills through coursework, experiential learning, mentorship, and participation in seminars and national and international meetings. Environment: Dr. Hauptman is supported by extensive research, professional, and academic resources at BCH, HMS, and Harvard T.H. Chan School of Public Health, including the BCH Institutional Centers for Clinical and Translational Research, Harvard-Chan NIEHS Center on Environmental Health, and the Harvard Catalyst Program. Her committed team of mentors and advisors include national experts in geospatial, air pollution and biomarker environmental exposure science and epidemiology, biostatistics/bioinformatics and clinical prediction methodology. Research: Despite increasing evidence of its adverse effects, air pollution has not been effectively addressed by healthcare providers in clinical medicine. Further knowledge is clearly needed, as elucidating robust environmental air pollutant biomarkers and readily available geospatial data as well as underlying mechanisms may lead to new therapeutic options and strategies for clinicians to better address a patient’s environment at the bedside. Dr. Hauptman proposes to build on prior work to rigorously evaluate and develop—through geospatial and biomarker environmental exposure science, epidemiology, and biomedical informatics—a feasible innovative Asthma Integrated Risk (AIR) Clinical Prediction model that relies on readily available data through patient report, the electronic medical record system, public available data sources and biomarkers that can assist clinicians in predicting high risk pediatric patients with asthma and potentially tailoring environmental and therapeutic interventions. At the end of this project, Dr. Hauptman will be well- positioned to apply for an R01 to further test whether implementation of this clinical decision support intervention improves asthma morbidity by more comprehensively identifying and addressing environmental air pollutants in children with chronic health conditions. The successful completion of this project will position Dr. Hauptman for the next stage of her career as an independent investigator addressing environmental exposures in clinical medicine.

项目概要/摘要候选人：Marissa Hauptman 博士是哈佛医学院 (HMS) 儿科讲师，儿科医生和环境医学毒理学家，以及儿科环境助理主任在波士顿儿童医院 (BCH) 健康中心，她完成了儿科住院医师实习和联合实习。在她早期工作的基础上，她获得了儿科环境医学和健康服务研究金。拟议的职业发展计划重点关注两个职业发展领域——地理空间和生物标记环境暴露科学、临床生物医学信息学——这将增加她的研究工具包，增加工作的严谨性，并增强她开发、评估和整合环境暴露的能力她将通过课程和体验获得这些技能。学习、指导和参加研讨会以及国内和国际会议。 Hauptman 得到了 BCH、HMS 和 HMS 的广泛研究、专业和学术资源的支持。哈佛大学陈曾熙公共卫生学院 (Harvard T.H. Chan School of Public Health)，包括 BCH 临床和转化研究、Harvard-Chan NIEHS 环境健康中心和哈佛催化剂她忠诚的导师和顾问团队包括地理空间、空气污染和环境领域的国家专家。生物标志物环境暴露科学和流行病学、生物统计学/生物信息学和临床研究：尽管有越来越多的证据表明空气污染有其不利影响，但它并没有改变。显然需要进一步的知识，阐明强大的环境空气污染物生物标志物和现成的地理空间数据以及潜在的机制可能会为忠诚者带来新的治疗选择和策略，以更好地解决问题 Hauptman 博士建议在之前的工作基础上严格评估和评估患者的床边环境。开发——通过地理空间和生物标记环境暴露科学、流行病学和生物医学信息学——一种可行的创新哮喘综合风险 (AIR) 临床预测模型，依赖于容易通过患者报告、电子病历系统、公共可用数据源和生物标志物可以帮助顾客预测患有哮喘的高风险儿科患者，并可能定制环境和治疗干预措施在该项目结束时，豪普特曼博士将很好地- 定位申请R01以进一步测试该临床决策的实施是否支持干预措施通过更全面地识别和解决环境空气问题来改善哮喘发病率该项目的成功完成将使博士能够定位于患有慢性健康问题的儿童。豪普特曼作为解决环境暴露问题的独立调查员，为她职业生涯的下一阶段做准备在临床医学中。