Administrative Core

行政核心

基本信息

批准号：
10221082
负责人：
Corinne Mary Linardic
金额：
$ 3.81万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-11 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10221082
关键词：
Administrator Advocate Affect Alveolar Rhabdomyosarcoma Annual Reports Biology Calendar Child Chimeric Proteins Collaborations Communication Communities Data Decision Making Development Doctor of Philosophy Educational workshop Ensure Evaluation Expenditure Experimental Designs FOXO1A gene Feedback Financial Support Fostering Goals Human Resources In Vitro Infrastructure Institutional Policy Laboratories Lead Leadership Link Logistics Malignant Childhood Neoplasm Malignant Neoplasms Molecular Target Monitor Occupational activity of managing finances Oncogenic PAX3 gene Patients Policies Problem Solving Process Proteins Publications Publishing Regulation Reporting Reproducibility Research Research Personnel Resource Sharing Rhabdomyosarcoma Risk Science Scientific Evaluation Scientist Technology Therapeutic Time United States National Institutes of Health Validation Vertebrates Work candidate validation career development data sharing experience experimental study high standard human subject in vivo meetings member multidisciplinary new technology novel strategies outreach programs treatment strategy web site working group

项目摘要

ABSTRACT – Administrative Core Fusion-positive alveolar rhabdomyosarcoma (ARMS) remains one of the most fatal but least understood cancers of childhood. Despite the 1993 identification of the PAX3-FOXO1 fusion protein as a key oncogenic driver of ARMS, treatment strategies for affected children remain unchanged. Thus the overarching goal of this FusOnC2 Center is to advance the therapeutic tractability of the PAX3-FOXO1 fusion protein in ARMS by comprehensively identifying the druggable co-regulators, modulators, and intrinsic activities of PAX3-FOXO1. In support of this, the Administrative Core will provide leadership, oversight, coordination, integration, dissemination and evaluation for the Center and connect it to the NCI FusOnC2 Consortium. Given our multi-disciplinary, multi-institutional team, these activities will enhance scientific rigor and accelerate our collective progress. Overall PIs Corinne Linardic, MD, PhD, and Christopher Counter, PhD will lead this Core, supported by the Executive Committee, Scientific Advisory Board (SAB), and administrative staff, including an experienced Center Administrator and an expert Financial Manager. Drs. Linardic and Counter, and the Executive Committee also will work closely with the NCI Program Officer, Project Scientist, and FusOnC2 Consortium Steering Committee regarding Center plans and direction. The Administrative Core proposes the following Specific Aims: 1) Provide organizational and logistical support for component activities; 2) Coordinate and enhance interactions among Center components; 3) Provide financial management and ensure fiscal and regulatory compliance; 4) Monitor scientific progress and scientific rigor; 5) Disseminate discoveries and collaborate; and 6) Establish mechanisms for internal and external review. Through the Center Executive Committee’s regular meetings, the Core will manage, coordinate, and integrate scientific activities across the Projects and Cores, provide transparency in decision-making, and facilitate participation in FusOnC2 Consortium activities. In addition to the Executive Committee meetings, the Administrative Core will coordinate meetings of a “Quantitative Sciences Working Group” to provide a layer of cross-Project data review and transparency, and to identify and ameliorate risks, including analyses that need to be confirmed or replicated by others, thus helping to ensure reproducibility. In conjunction with the FusOnC2 Consortium Steering Committee, the Administrative Core will develop and implement policies for timely data sharing and publication. The Administrative Core will serve as the “hub” for our Center’s activities to accelerate progress and enhance rigor, and as the link to other FusOnC2 Centers for development and conduct of collaborative Consortium projects. Through our outreach plan, the Core will nurture trainees’ career development and promote data and resource sharing. This Center is committed to full participation in FusOnC2 Consortium activities, and the research team welcomes this opportunity to apply ambitious new technologies and approaches to solve the problem of fusion protein-fueled cancers.

摘要 – 行政核心融合阳性肺泡横纹肌肉瘤（ARMS）仍然是最致命但最不为人所知的癌症之一尽管 1993 年 PAX3-FOXO1 融合蛋白被鉴定为关键的致癌驱动因素。 ARMS，受影响儿童的治疗策略保持不变，因此 FusOnC2 的总体目标保持不变。中心旨在通过全面提高 PAX3-FOXO1 融合蛋白在 ARMS 中的治疗可处理性鉴定 PAX3-FOXO1 的可药物协同调节剂、调节剂和内在活性支持这一点，行政核心将提供领导、监督、协调、整合、传播和评估鉴于我们的多学科、多机构，该中心并将其连接到 NCI FusOnC2 联盟。团队，这些活动将提高科学严谨性并加速我们 PI Corinne 的整体进步。 Linardic 博士和 Christopher Counter 博士将在执行委员会的支持下领导该核心，科学顾问委员会 (SAB) 和行政人员，包括经验丰富的中心管理员和专家财务经理 Drs. Linardic 和 Counter 以及执行委员会也将与他们密切合作。 NCI 项目官员、项目科学家和 FusOnC2 联盟指导委员会关于中心行政核心提出以下具体目标： 1) 提供组织和指导。 2）协调和加强中心各部门之间的互动； 3) 提供财务管理并确保财务和监管合规性； 4) 监控科学进展和科学研究；5) 传播发现和合作；以及 6) 建立内部和外部机制通过中心执行委员会的定期会议，核心将进行管理、协调、整合跨项目和核心的科学活动，提供决策的透明度，以及促进参与 FusOnC2 联盟活动除了执行委员会会议之外，行政核心将协调“定量科学工作组”的会议，以提供一层跨项目数据审查和透明度，并识别和改善风险，包括需要的分析被其他人确认或复制，从而有助于确保与 FusOnC2 结合的可重复性。联盟指导委员会、行政核心将制定和实施及时数据政策行政核心将作为我们中心加速活动的“中心”。进步并提高严谨性，并作为与其他 FusOnC2 中心的联系，以开发和开展通过我们的外展计划，核心将培养学员的职业发展。促进数据和资源共享。本中心致力于全面参与FusOnC2联盟。活动，研究团队欢迎有机会应用雄心勃勃的新技术和方法解决融合蛋白驱动的癌症问题。