Biological Mechanisms of Perinatal Anxiety

围产期焦虑的生物学机制

• 批准号: 10210201
• 负责人: Lauren M Osborne
• 金额: $ 19.59万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-16 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10210201
• 关键词: Address; Affective Symptoms; Allopregnanolone; Anti-Anxiety Agents; Anxiety; Arousal; Attention deficit hyperactivity disorder; Autoimmune Diseases; Behavior; Biological; Biological Markers; Biometry; Blood specimen; Cells; Chemicals; Child; Cognitive deficits; Data; Data Analyses; Diagnostic; Disease; Educational workshop; Endocrine; Endocrine system; Epidemiology; Fingerprint; Fright; Future; Genetic Transcription; Gestational Diabetes; Goals; Health; Hormonal; Immune; Immune system; Immunity; Immunologic Factors; Immunologic Markers; Immunologics; Immunology; Individual; Individual Differences; Infection; Inflammatory; Knowledge; Laboratories; Learning; Leukocytes; Maternal and Child Health; Measurement; Measures; Mental Depression; Mental Health; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Methylation; Mission; Molecular Weight; Mothers; Nature; Neurobiology; Neuroendocrinology; Obsession; Organism; Patient Self-Report; Pattern; Perinatal; Peripheral; Pharmaceutical Preparations; Physiological; Physiology; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Postpartum Depression; Postpartum Period; Pre-Eclampsia; Pregnancy; Pregnant Women; Premature Birth; Progesterone; Proteins; Psychiatry; Psychoneuroimmunology; Psychopathology; Public Health; Reaction Time; Research; Research Domain Criteria; Risk; Risk Marker; Scientist; Solid; Stimulus; Suicide; Symptoms; Techniques; Th2 Cells; Time; Training; United States National Institutes of Health; Woman; adaptive immunity; anxiety states; anxiety symptoms; anxious; attentional bias; base; career; child bearing; cohort; conduct problem; cytokine; disability; experience; improved; maternal anxiety; meetings; monocyte; novel; perinatal period; prenatal; programs; prospective; reproductive; research study; response; skills; stressor; symposium; tool

PROJECT SUMMARY/ABSTRACT This is an application for a Mentored Patient-Oriented Research Career Development Award. The goal of the proposed project is to provide me with the advanced training necessary to establish an independent program of research in perinatal psychiatric disorders, and specifically in the contributions of immunological and endocrinological factors to perinatal psychopathology. To facilitate this long-term career goal, I will examine biological correlates of anxiety across pregnancy and the postpartum. I propose a comprehensive training plan, combining formal coursework in immunology and biostatistics with individual mentor meetings, applied training experiences, and participation in conferences, seminars, and workshops. Specific short-term training goals include: 1) Develop expertise in the psychoneuroimmunology of pregnancy and the postpartum 2) Gain a fuller understanding of reproductive hormonal physiology 3) Improve my understanding of biostatistics and epidemiology and develop a solid understanding of longitudinal data analysis 4) Refine my skill in measuring perinatal anxiety by learning how to administer laboratory stressors to pregnant women and measure the resultant autonomic reactivity and 5) Become adroit at integrating information about perinatal anxiety across numerous RDoC units of analysis, including cells, physiology, behaviors, self-reports, and paradigms. The training plan will be executed in conjunction with a proposed set of research studies based on preliminary data that I have collected and/or analyzed. These data demonstrate a relationship between inflammatory cytokines and TRAIT anxiety in pregnancy; between pro-inflammatory cytokines and STATE anxiety across the perinatal period; between allopregnanolone and obsessive symptoms in pregnancy; and between allopregnanolone in pregnancy and subsequent postpartum affective symptoms. The proposed research will build upon these preliminary findings by prospectively following a cohort of anxious pregnant women and healthy matched controls; by analyzing their blood samples for inflammatory cytokines, immune cells, and allopregnanolone; and by measuring maternal reactivity to a validated pregnancy-specific laboratory task that will measure attentional bias to threat and act as a stimulus for autonomic arousal.

项目概要/摘要 这是一份以患者为导向的研究职业发展奖的申请。拟议项目的目标是为我提供必要的高级培训，以建立围产期精神疾病的独立研究计划，特别是免疫学和内分泌因素对围产期精神病理学的贡献。为了实现这一长期职业目标，我将研究怀孕期间和产后焦虑的生物学相关性。我提出了一个全面的培训计划，将免疫学和生物统计学的正式课程与个人导师会议、应用培训经验以及参加会议、研讨会和讲习班结合起来。具体的短期培训目标包括： 1) 培养妊娠期和产后心理神经免疫学方面的专业知识 2) 更全面地了解生殖激素生理学 3) 提高对生物统计学和流行病学的理解，并对纵向数据分析有深入的了解 4)通过学习如何向孕妇施加实验室压力并测量由此产生的自主反应性，提高我测量围产期焦虑的技能，并且 5) 熟练地整合以下信息：围产期焦虑涉及多个 RDoC 分析单元，包括细胞、生理学、行为、自我报告和范式。培训计划将与基于我收集和/或分析的初步数据的一组拟议研究一起执行。这些数据证明了妊娠期炎症细胞因子与特质焦虑之间的关系；促炎细胞因子与围产期状态焦虑之间的关系；别孕酮与妊娠期强迫症状之间的关系；以及怀孕期间的四氢孕酮和随后的产后情感症状之间的关系。拟议的研究将建立在这些初步发现的基础上，前瞻性地跟踪一组焦虑的孕妇和健康的匹配对照；通过分析他们的血液样本中的炎症细胞因子、免疫细胞和四氢孕酮；并通过测量母亲对经过验证的怀孕特定实验室任务的反应，该任务将测量对威胁的注意力偏差并作为自主神经唤醒的刺激。

项目成果

Perinatal Obsessive-Compulsive Disorder: Epidemiology, Phenomenology, Etiology, and Treatment.

围产期强迫症：流行病学、现象学、病因学和治疗。

• 发表时间: 2022-04
• 影响因子: 6.7
• 作者: Hudepohl, Neha;MacLean, Joanna V;Osborne, Lauren M
• 通讯作者: Osborne, Lauren M

Maternal behavioral health symptom profiles in early family life: complexity and context.

早期家庭生活中的母亲行为健康症状概况：复杂性和背景。

• 发表时间: 2020-06
• 作者: Weiss;Johnson, Sara B;Ghazarian, Sharon R;Osborne, Lauren M;Riley, Anne W
• 通讯作者: Riley, Anne W

Is Valproate Reasonable?

丙戊酸合理吗？

• 发表时间: 2021
• 作者: Leistikow, Nicole;Smith, Milena H;Payne, Jennifer L;Osborne, Lauren M
• 通讯作者: Osborne, Lauren M

Neuroactive Steroids and Perinatal Depression: a Review of Recent Literature.

神经活性类固醇和围产期抑郁症：近期文献综述。

• 发表时间: 2018-08-09
• 影响因子: 6.7
• 作者: McEvoy, Katherine;Payne, Jennifer L;Osborne, Lauren M
• 通讯作者: Osborne, Lauren M

Recognizing and Managing Postpartum Psychosis: A Clinical Guide for Obstetric Providers.

认识和管理产后精神病：产科提供者的临床指南。

• 发表时间: 2018-09
• 影响因子: 3.2
• 作者: Osborne; Lauren M
• 通讯作者: Lauren M